PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.
Actihaemyl ; Anesthesia, General* ; Eyelids ; Humans ; Hyperemia ; Lanolin ; National Eye Institute (U.S.) ; Prospective Studies ; Tears

PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.
Actihaemyl ; Anesthesia, General* ; Eyelids ; Humans ; Hyperemia ; Lanolin ; National Eye Institute (U.S.) ; Prospective Studies ; Tears

Lanolin is a complex material consisting of a mixture of numerous esters and polyesters of high-moleculer-weight alcohols and fatty acids, Lanolin allergy is important because lanolin is widely used as an emulsifier in topical medicaments and in numerous cosmetic preparations. We report a case of allergic contact dermatitis in a 27-year-old female. An erythematous pruritic rash develgood around the eyelid developed after applying a new eye cream and was aggravated after applying Cambison ophthalmic ointment. Patch testing showed positive reactions to Cambison ophthalmic ointment, 30% wool alcohol, Amerchol L101 and Nivea cream. A use test with 100% Cambison ophthalmic ointment base was positive
Adult ; Alcohols ; Dermatitis, Allergic Contact* ; Esters ; Exanthema ; Eyelids ; Fatty Acids ; Female ; Humans ; Hypersensitivity ; Lanolin* ; Patch Tests ; Polyesters ; Wool

BACKGROUND AND OBJECTIVES: Many people experience problems with a dry nasal mucous membrane, often without wondering why. The cause of problem is known as rhinitis sicca, senile rhinitis, and atrophic rhinitis, etc. A common form of treatment for patients who have such symptoms has been to begin by rinsing the inside of the nose with saline solution, to drop peanut oil, to apply antibiotic-ointment and moisturizing agents. Lanolin has been know as a safe skin moisturizing agent and used to treat dry nose. The purpose of this study was to evaluate the effect of lanolin on a group of patients seeking treatment for dryness of the nose. MATERIAL AND METHODS: Ninety-three patients experiencing problems with dry nasal mucosa were selected from the out-patient clinic. Fifty-seven patients, average age 36.3 years old, were treated with 1:2 mixture of lanolin and vaseline ointment. Thirty-six patients, average age 32.0 years, were treated with vaseline ointment. Both ointments were applied three times a day for two weeks. The efficacy of treatment was determined with pre and post-treatment six symptoms on a visual analogue scale: nasal obstruction, crust formation, mucosal dryness, respiratory discomfort, sleep disturbance, and general discomfort. RESULTS: For subjects treated with lanolin, the average VAS value for nasal obstruction was 5.84+/-2.28 and it decreased to 2.89+/-1.29, while the corresponding values for subjects treated with vaseline were 4.39+/-1.77 decreasing to 3.11+/- 1.24 (p<0.05). Crust formation of lanolin treated subjects were 5.67+/-2.39 and it decreased to 2.09+/-1.46, while the vaseline treated subjects were 4.83+/-1.99 decreasing to 2.33+/-1.31 (p<0.05). Average total symptom improvement was 65.7% (from 27.95+/-9.30 to 9.86+/-4.58) in lanolin treated group, while it was 44.8% (from 20.9+/-76.59 to 11.64+/-4.18) in vaseline treated group. CONCLUSION: We found that the efficacy of lanolin was statistically signigicantly better than that of vaseline. During the study period, there was no local reactions have been reported, nor have any allergic reactions. The present study underlines the fact that the way to treat nasal mucosal dryness is to use lanolin ointment.
Humans ; Hypersensitivity ; Lanolin* ; Mucous Membrane ; Nasal Mucosa ; Nasal Obstruction ; Nose* ; Ointments ; Outpatients ; Petrolatum ; Rhinitis ; Rhinitis, Atrophic ; Skin ; Sodium Chloride

A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Antioxidants ; Dermatitis ; Dermatitis, Allergic Contact* ; Humans ; Lanolin ; Patch Tests ; Polyethylene Glycols ; Propylene Glycol ; Sodium Dodecyl Sulfate ; Surface-Active Agents ; Turpentine

Neomycin is one of the aminoglycoside antibiotics and not uncommonly causes allergic contact dermatitis. Wool alcohol is one of the most widely used lanolin bases and rarely has been reported to cause allergic contact dermatitis. A 63-year-old male presented with a pruritic, erythematous swelling on the right periorbital area. He had a cataract operation on his right eye 10 days ago and has applied several eye drops and topical antibacterial agents. Patch test with Korean standard antigens and ophthalmic preparations revealed strong positive reactions to neomycin sulfate and the Maxitrol ointment composed of dexamethasone, neomycin sulfate and polymyxin B, and positive reaction to wool alcohol. Neomycin may be the major causative agent to produce allergic contact dermatitis, and wool alcohol also has some relation to it.
Anti-Bacterial Agents ; Cataract ; Dermatitis, Allergic Contact* ; Dexamethasone ; Humans ; Lanolin ; Male ; Middle Aged ; Neomycin ; Ophthalmic Solutions ; Patch Tests ; Polymyxin B ; Wool

The present study was performed to evaluate the comedogenicity of several cosmetic ingredients, vegetable oils, steroid and sulfur. The test materials were applied to one ear canal of rabbits for 6 weekdays for 2 weeks. The results were as follows: l. Among the 14 cosmetic ingredients, no comedogenicity was shown in propylene glycol and petrolatum, mild comedogencity in squalene, acetylated lanolin, polyethylene glycol, cetyl aIcohol and Tween 80. Propylene glycol, sodium lauryl sulfate and oleic acid showed moderate comedogenicity. Severe comedogenicity was observed in myristyl myristate, isopropyl myristate, butyl stearate and myristyl lactate. 2. Moderate to severe comedogenicity was shown in olive oil, sesame oil and corn oil and moderate comedogenicity in sulfur (8%) and betamethasone dipropionate (0.06%) R. Histopathologic grading were paralleled the findings of the naked eye.
Betamethasone ; Corn Oil ; Ear Canal ; Lactic Acid ; Lanolin ; Myristic Acid ; Olea ; Oleic Acid ; Petrolatum ; Plant Oils ; Polyethylene Glycols ; Polysorbates ; Propylene Glycol ; Rabbits ; Sesame Oil ; Sodium Dodecyl Sulfate ; Squalene ; Sulfur ; Olive Oil