Objective To evaluate the reliability and validity of Chinese version of the Carlson's Prior Conditions Instruments(CPCI)for post-operative pain management practices of nurses.Methods With convenience sampling,a total of 200 surgical nurses were investigated with Chinese version Dimensions of Carlson's Prior Conditions Instruments (CPCI),and the reliability and validity were tested.Results Six factors were extracted by factor analysis and could explain 61.089％ of the total variance with the Chinese version of CPCI.The correlation between each sub-scale and total scale were ranged from 0.583～0.825.The Cronbach's α、split-half coefficient and test-retest reliability of PICI were 0.865、0.661、0.904 respectively.The Cronbach's α、split-half coefficient and test-retest reliability of each sub-scale were ranged from 0.772～0.860、0.678～0.830、0.822～0.946 respectively.Conclusions The revised Chinese CPCI is reliable and valid,and can be used in the research of prior conditions which may influence surgical nurses to take evidence-based pain management practices.

ObjectiveTo evaluate the reliability and validity of Chinese version of Postoperative Pain Assessment Nursing Practice Questionnaire (PPA-NPQ).MethodsA forward-backward translation procedure was followed to develop the Chinese version of PPA-NPQ.A total of 258 surgical nurses were investigated by the revised Chinese version dimensions of PPA-NPQ,then the results were tested on reliability and validity by SPSS17.0.ResultsThe cronbach's α of the Chinese version of PPA-NPQ was 0.889.The split- half coefficient and testretest reliability of PPA-NPQ were 0.729,0.875 respectively ; the Cronbach's a,split- half coefficient and test-retest reliability of each sub-scale were ranged from 0.820-0.857,0.797-0.862,0.846-0.902 respectively.The correlation between each sub-scale and total scale were ranged from 0.704-0.818 (P ＜ 0.01 ).ConclusionThe revised Chinese PPA-NPQ is reliable and valid,and can be used to test the level of postoperative pain assessment practice by surgical nurse.

Objective To evaluate the effect of preoperative ambroxol aerosol inhalation on postoperative lung complications in patients with chest and abdominal surgery.Methods The randomized controlled trials (RCTs) taking preoperative ambroxol aerosol inhalation interventions were collected from the databases of Chinese Technology Journal Database,China National Knowledge Internet and Wanfang Database.Data were analyzed with RevMan 5.0 software.Results Eleven articles with 1 160 patients met the inclusion criteria.There was a certain heterogeneity across the analysis,which might result from kind of included patients,inhalation method,difference of the medication,inhalation time,etc,according to subgroup analysis.The result showed that compared with the control group,patients in the experimental group had lower incidence of postoperative lung complications and the differences were not statistically significant.Conclusions The Meta analysis had identified a significant effect of preoperative ambroxol aerosol inhalation on postoperative lung complications in patients with chest and abdominal surgery,but high quality were in need.

Objective To define the concept of the benefit finding of breast cancer patients by Morse,Hupcey and Penrod's developed analytical methods.Methods Twenty-two references were recruited through the databases of Medline,Cochrane Library,Embase,Web of Science,ProQuest,according to the inclusion and exclusion criteria.Coding related content of literatures based on the concept of property from Morse terms:boundaries,preconditions and outcome,and from the epistemological,pragmatics,linguistics,logic perspective to evaluate the maturity of the concept.Results The benefit finding of breast cancer patients involved a perception of cognitive processes,including the three attributes,three word boundaries,two preconditions and three results.Development of the concept was not fully mature.Conclusions Clarifying the benefit finding of breast cancer patients can help researchers use the techniques and principles of positive psychology to promote the benefits finding of breast cancer patients and the patients' physical and mental rehabilitation.

Objective We sought to summarize the experience in nursing the patients of Robertsonian translocation receiving pre-implantation genetic diagnosis (PGD).Methods Thirty-eight patients with Robertsonian translocation received PGD.These patients received health education and psychological nursing except for routine therapy and nursing.Results All these patients had no obvious negative emotion and complied with the therapy.Nine patients were successfully pregnant and pregnancy rate was 23.7％,7 of them delivered healthy neonates.Conclusions Health education,psychology nursing together with controlled ovarian stimulation,egg retrieval and embryonic transplantation can reduce negative emotion,improve compliance of therapy,and benefit the process of PGD and clinical outcomes.

Objective To compare the preoperative eternal nutrition bowel preparation method with the conventional method in the intestinal cleansing effect,postoperative infection and postoperative complications of gastrointestinal function recovery time,and to provide reference for selection for our clinical preoperative practice.Methods Computer Retrieval of Chinese Biomedical Literature Database,VIP Chinese Science and Technology Journal Full-text Database and China Academic Journal was conducted.The time limit was from establishment of database till May 2013.The research type was randomized controlled trial.Two investigators independently screened,assessed quality and extracted data according to the inclusion and exclusion criteria for literatures,and cross-checked them using RevMan 5.0 software for Metaanalysis,then applied the grading method recommended by the GRADE grading system.Results Ultimately seven RCTs were included,with a total of 478 cases of colorectal cancer patients.Compared with conventional preoperative bowel preparation,eternal nutrition method showed similar bowel cleansing effects and the incidence of complications,but it could shorten the postoperative recovery of gastrointestinal function time,lower positive rate of abdomen,intestine shedding of tumor cells,improve postoperative albumin and transferritin levels.Conclusions Eternal nutrition alternative method for bowel preparation before colorectal surgery is safe and effective.

Objective To discuss the different factorial structure of HAMD Scale between the patients of liver Qi stagnation syndrome and liver stagnation and spleen deficiency syndrome. Methods Factorial structure of HAMD Scale of 91 depression patients of liver Qi stagnation syndrome and liver depression and spleen deficiency syndrome were statistically analyzed. Result There was difference between the two types of patients in factorial structure of HAMD Scale (P

Objective To investigate whether the new mechanically-activated (MA) cation channel Piezo 1 protein can cause the apoptosis of human chondrocytes under compressive loading,using a Flexercell unit by activating MAPK/ERK5 signal pathway.Methods Primary human chondrocytes were isolated,cultured,and then subjected to the static compressive loading for 2 h,12 h,24.h and 48 h,respectively.The GsMTx4,which is the special inhibitor of the Piezo1 protein and the BIX02188,which is the inhibitor of the ERK5 served as the inhibitor group.The immunofluorescence was used to locate the expression of the Piezo 1 protein.The expressions of Piezo1 and ERK5 were assessed by reverse transcription-polymerase chain reaction (RT-PCR),as well as the apoptosis gene B cell lymphoma/leukemia-2 (Bcl-2),Bcl-associated X protein (Bax) and Bcl-associated death promoter (BAD).In addition,Piezo1 inhibitor,GsMTx4,was used to block the MA cation channel Piezo1,served as the inhibitor group.AVPI was used to detect the apoptosis of the OA chondrocytes.Results The location of the Piezo1 was expressed in nucleus and cytoplasm of chondrocytes.The expression of the Piezo1,ERK5,BAD,and Bax mRNA in the OA chondrocytes is weak.The 12 h stretch force group was significant increased,and the 24 h stretch force group was the highest expression.However,the expression of the 48 h group was decreasing.The expression of the Bcl-2 in the 12 h group was decreasing,and the 12 h stretch force group was the lowest expression while the 24 h stretch force group was increasing.In the GsMTx4 group,the expression of the Piezo1,ERK5,BAD,Bax was decreasing while the Bcl-2 was increasing.In the BIX02188 group,the expression of the ERKS,BAD,Bax was increasing while the Bcl-2 was decreasing,while the expression of the Piezo1 was not change.The result of AV-PI shown that the 2 h stretch force group increased early stage of apoptosis.The 12 h stretch force group increased late stage of apoptosis,and the 24 h stretch force group's apoptotic rate was the highest.However,the apoptotic rate of the 48 h group was lower than the 24 h stretch force group.The GsMTx4 could inhibit the late stage of apoptosis.Conclusion Piezo 1 plays an important role in the apoptosis of human chondrocyte through the MAPK/ERK5 signal pathway.

BACKGROUND: The main reason for the postoperative loosening of cemented prosthesis is interfacial debonding and bone cement internal damage. Most studies have suggested that both of them occur in the process of fatigue damage, however, little is reported on primary loading that results in the initial damage to the bone cement-stem interface and inside of bone cement. OBJECTIVE: To study the mechanical properties of bone cement-stem interface, and the effect of crack formation in bone cement on interfacial loosening. METHODS: The cement-titanium al oy handle implant components were prepared. The maximum adhesive force of bone cement-stem interface was measured using push-in experiment. The cement damage and crack in the process of bone cement-handle interfacial debonding were monitored online using acoustic emission tester. The non-destructive testing on the metal surface and the inner layer of bone cement cylinder was conducted using three-dimensional surface profiler, ultrasonic microscopy and X-ray detector. RESULTS AND CONCLUSION: The online monitoring results of debonding experiment and acoustic emission tester demonstrated that the initial damage of bone cement initiated in the primary loading of patients after operation, rather than at fatigue damage stage. Bone cement coffin caused cracks initiation mainly due to the combination effect of radial and axial stress. The bone cement-stem interfacial shear lag effect could not prevent the gradual extension of interface and inner coffin crack from top to bottom. The bone cement defects formed in solidification process was likely to affect the mechanical properties of the material, and eventual y induced the crystal face and macromolecular chain fractures, forming silver striated cracks and leading component failure.

Objective To understand the status and influencing factors of benefit finding in patients with cancer.Methods 350 patients with cancer were collected with convenience sampling method from two Jiangsu hospitals.All patients received a questionnaire survey.Multiple linear regression analysis was used to analyze the influencing factors of benefit finding in patients with cancer.Results (1) The score of benefit finding in patients with cancer was statistically significant in different frequency of physical exercise (F=8.37,P=0.00),different character (F=3.04,P=0.04) and different educational level (F=2.91,P=0.03).(2) There was a positive correlation between benefit finding(78.53± 10.50) and communication with physicians(7.27±2.19),medical coping(43.48±4.50),optimism(17.33±2.24) and social support(44.81±3.91)(r=0.31,0.35,0.29,0.23,all P＜0.05) in patients with cancer.The benefit finding in patients with cancer was negatively correlated with depression(8.59± 1.83) (r=-0.37,P＜0.05).(3) Multiple linear regression analysis results showed that medical coping modes-confrontation,objectively social support and utilization,physical exercise,depression,communication with physicians and character were the factors influencing benefit finding in patients with cancer(△R2 =28％,P＜ 0.05;△R2 =5.5％,P＜ 0.05;△R2 =3.1％,P＜ 0.05;△R2 =1.9％,P＜0.05;△R2 =1.7％,P＜0.05;△R2 =1.0％,P＜0.05;△R2 =1.1％ P＜0.05),which explained 42.0％ of the total variance.Conclusion Medical coping modes-confrontation,objectively social support and utilization,physical exercise,depression,communication with physicians and character are the factors influencing benefit finding in patients with cancer.