1.Network-based analysis of public sentiments on violent events in medical staff
Lifu CHEN ; Lancheng WANG ; Long SU ; Yongqin HUANG
Chinese Journal of Medical Library and Information Science 2014;(1):29-33
Objective To study the features and reasons of violent events in medical staff and the public sentiments on them based on a network analysis. Methods The data of violent events in medical staff were down-loaded from Internet. The annual and geographic distribution and reasons of violent events in medical staff, casualties of medi-cal staff and the public opinions on the major Websites were analyzed. Results The number of violent events in medical staff increased to 31 in 2012 from 1 in 2003. The violent events were distributed in 18 provinces of China, the number of casualties was 105 , and 53% of the violent events occurred due to the unsatisfactory therapeutic out-comes in patients. Conclusion The public sentiments on violent events in medical staff tend to increase on Internet and characterized by no signs and direct conflict between patients or their family members before attacking medical staff, and against general medical staff. Public sentiments on violent events in medical staff are easy to become hot events with significant negative effects on the society. Medical institutions and hospitals should prevent such events and play an active role in guiding the public sentiments.
2.Identification of novel pathogenic variants of TRIOBP gene in a pedigree affected with non-syndromic deafness.
Menglong FENG ; Kai ZHOU ; Lancheng HUANG ; Fengzhu TANG ; Shenhong QU ; Qiutian LU ; Ruichun CHEN ; Fengti LI
Chinese Journal of Medical Genetics 2021;38(5):454-457
OBJECTIVE:
To explore the genetic basis for a Chinese pedigree affected with non-syndromic hearing loss (NSHL).
METHODS:
Commercialized gene chip was applied to detect common mutations associated with congenital deafness. Whole exome sequencing was carried out for patients for whom gene chip yielded a negative result. Candidate variants were verified by Sanger sequencing.
RESULTS:
Two patients from the pedigree were discovered to carry compound heterozygous variants of the TRIOBP gene, namely c.3299C>A and c.5185-2A>G. Their parents had normal hearing and were both heterozygous carriers of the above variants. Both variants had co-segregated with the disease phenotype in the pedigree and were unreported previously.
CONCLUSION
Pathogenic variants of the TRIOBP gene comprise an important factor for NSHL. The novel c.5185-2A>G and c.3299C>A variants discovered in this study have enriched the mutational spectrum of the TRIOBP gene and enabled molecular diagnosis and genetic counseling for the family.
Deafness/genetics*
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Hearing Loss, Sensorineural/genetics*
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Heterozygote
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Humans
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Microfilament Proteins/genetics*
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Mutation
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Pedigree
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Whole Exome Sequencing