125 cases of JRA was diagnosed and treated in Children's Hospital I (HCM city) during Jan 1996 - Apr 1998, among them 123 were diagnosed radiographically at admission, their 18,7% had bone damages. Permanent damage of cartilage and subchondral structure or deformity of bone due to chronic synovitis were reported. The role of proinflammatory cytokin such as IL-1, TNF alpha. IL-6 and IL-8 in pathogenesis of RA and JRA has been established. Anti-inflammatory and antirheumatismal medications improved the outcomes. Radiography of bonejoint is helpful for diagnosis.
Bone and Bones ; Arthritis, Rheumatoid

The diagnosis of systemic onset JRA may be very difficult, especially at the onset of the disease. A proposes of three cases with systemic pattern, we would like to emphasize this opinion. The first case is an acute lymphoblastic leukemia with RF positive. The second is really a systemic JRA that was the same as Kawasaki disease. And the third is a systemic manifestation of an auto- immune disease class II (non organo specific) with FR and ANA positive. Rheumatoid factors are neither specific for nor diagnosis of JRA, especially at systemic onset JRA. Systemic onset JRA is a diagnosis of exclusion.
Arthritis, Rheumatoid ; Child

Background: Sciatic neuralgia syndrome is a quite common condition in clinical of internal medicine diseases. The syndrome is not life threatening but reduce the ability to work and activities of the patients. The disease is more common in men than women and most of working age.\r\n', u'Objectives: To define the clinical characteristics of sciatic neuralgia syndrome. \r\n', u'Subjects and methods: The cross sectional study was carried out on 48 sciatic neuralgia patients aged from 16 to 70, treated at Bach Mai hospital. The research indices were clinical and traditional medicine characteristics of sciatic neuralgia syndrome.\r\n', u'Results: Sciatic neuralgia was common in the 20-39 year old (87.5%) age group. The male to female ratio was 1.7 (p<0.01). The sciatic neuralgia syndrome rose after excessive exercise (50%). In almost hernia cases of vertebral disc on spinal column was detected by MRI (83.3%). The impaired nerve root was L5 (64.6%). Acupuncture sites were on gallbladder meridian (50.0%), bladder meridian (20.8%) and coordinated (29.2%)\r\n', u'Conclusion: The sciatic neuralgia syndrome causing hernia on spinal column was common at 20-59 year old age. The male number was higher than female. Almost sciatic neuralgia patients had noticed pain on the gallbladder meridian (p<0.05).\r\n', u'\r\n', u'
sciatic neuralgia syndrome ; clinical characteristic

Background: In many studies on aplastic anemic patients, hemorrhage syndrome is expressed in mainly subcutaneous hemorrhage, gum hemorrhage and menorrhagia in women. In traditional medicine, there are many remedies to treat the hemorrhage syndrome in aplastic anemic patients, such as \u201cBao nguyen thang\u201d, \u201cNhi tien thang\u201d, \u201cNhi chi hoan\u201d, \u201cO ke bach Phuong hoan\u201d, \u201cQuy ty thang\u201d herbal remedies\u2026 Objectives: To research the effects of supplemental treatment for hemorrhage syndrome by \u201cDuong quy bo huyet thang\u201d herbal remedy on aplastic anemic patients. Subjects and method: A study was carried out on 60 aplastic anemic patients at Bach Mai Hospital from October 2006 to October 2007. The subjects were divided into two groups: group I was treated with blood transfusion, corticoid and supplemental treatment by \u201cDuong quy bo huyet thang\u201d remedy; group II was only treated with blood transfusion and corticoid. This was a controlled, randomized clinical trial. Results: The average age of the patients was 40.57 +/- 16.77 years in group I and 41.73 +/- 17.14 years in group II (p>0.05). The male-female ratio was 1.07. The number of patients with hemorrhage syndrome decreased from 66.7% to 36.7% after 60 days of treatment. The platelet counts increased from 20.85 +/- 13.57 g/l to 28.94 +/- 16.92 g/l (p<0.05). Conclusions: The \u201cDuong quy bo huyet thang\u201d herbal remedy decreased hemorrhage syndrome in aplastic anemic patients.
\u201cDuong quy bo huyet thang\u201d remedy ; hemorrhage syndrome ; aplastic anemia

Background: Ventricular Septal Defect (VSD) is one of the most common congenital cardiac diseases, accounting for 20%, and affects the left ventricular function. There is no study on the application of Tei index to evaluate left ventricular function in patients with VSD in Vietnam. Objective:To assess left ventricular function in ventricular septal defect by Tei index. Subject and Method: A cross-sectional descriptive study that involves 35 patients of VSD with an average age of 15.77+/-10.41 (A group: 19 patients of VSD with systolic pulmonary artery pressure (PAPs) < 40 mmHg and B group: 16 patients of VSD with PAPs>=40mmHg and control group: 30 normal volunteers). Results: Tei index for estimation of left ventricular function is higher in the VSD (0.50+/- 0.18) than the control (0.37 +/- 0.03) with p < 0.01, exponentially more in the VSD with PAPs >=40mmHg (0.64 +/- 0.15; p<0.01). Conclusion: Left ventricular function is worse in VSD patients in comparison to the healthy people.
Ventricular Septal Defect ; Tissue Doppler ; Tei index

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and deformity of the joints. Objectives: The study have two purposes: (1) Identify the sensitivity of anti - CCP2 antibodies in rheumatoid arthritis. (2) Identify the correlation between anti - CCP2 antibodies and clinical manifestations, laboratory features of rheumatoid arthritis. Subjects and method: The study was carried out on 70 patients with rheumatoid arthritis from March to July 2006 in rheumatology department at Bach Mai hospital. All they were diagnosed according to the criteria of American College of Rheumatology 1987. Results: Results of study showed that: (1) The sensitivity of anti - CCP2 antibodies is 67.1% (2) The sensitivity of anti - CCP2 antibodies in patients with rheumatoid arthritis is 67.1 % and is as high as the sensitivity of rheumatoid factor. In early stage of disease (the duration of disease under 12 months) the sensitivity of anti - CCP2 antibodies is higher than rheumatoid factor (70% versus 57.5%). There are no significant differences between the group having anti - CCP2 antibodies and the group who did not have anti - CCP2 anti- bodies in any stages of disease about Ritchie index, DAS - 28 index, X - rays, erythrocyte sedimentation rate in the first hour, CRP ratio. Conclusions: The sensitivity of anti - CCP2 antibodies in patients with rheumatoid arthritis is 67.1 %. There is the relation between anti - CCP2 antibodies and the severity of the inflammation and the severity of X - rays.
Arthritis ; Rheumatoid/ pathology ; epidemiology ; Antibodies/ adverse effects

Background: HIV (human immunodeficiency virus) is the virus that causes AIDS. This virus is passed from one person to another through blood-to-blood and sexual contact. In addition, infected pregnant women can pass HIV to their baby during pregnancy or delivery, as well as through breast-feeding. Objectives:To study the CCR5- 32 and SDF 1-3 A allelic frequence in the HIV -1 infected mothers and their children. Subjects and method: Amplificated on CCR5 and SDF1 gene by PCR and restriction of this fragment length polymorphisme (RLFP) assay for detection of the mutated gene by EcoR1 and Hpall. Results: No mutation of CCR5 was found but only mutation identified at the SDF1 gene. Mutation identified at the SDF1 gene of the mother was: homozygote 2.7% (accounted for 2/37 cases), heterozygote 40.54% (accounted for 15/37 cases) and at the children: homozygote 5.4% (accounted for 1/37 cases), heterozygote 45.95% (accounted for 17/37 cases). The CCR5 chemokin receptor is a co-receptor for M trofic HIV-1 strains, which predominate in the early stage of the HIV disease and SDF-1 natural ligand for the CXCR4 reception. The mutation of these genes protect from HIV-1 infection (slow progression).\r\n', u'Conclusion: It\u2019s necessary to find the mutation of CCR5 and CCR2b related the progression of HIV patients. \r\n', u'
HIV-1/ metabolism ; Receptors ; CCR5

Background: Depression is a mental disorder common worldwide. This study determined the relationships between demographics, health status, household parameters, and depression rates among working-age household heads. Methods: We analyzed data from the Korea Welfare Panel Study Survey conducted in 2020. The 11-item version of the Center for Epidemiologic Studies Depression Scale was used to assess depression. Bivariate analyses and a multiple logistic regression model were used to evaluate the influence of these factors on depression among household heads. Results: The overall prevalence of depression among working-age household heads was 11.69% (19.83% of females and 9.58% of males). The relative risk of depression was 1.71 times higher among the unemployed than among wage earners and 2.18 times higher among those with low income than among those with general income. The relative risk of depression was 3.23 times higher in those with poor health status than in those with good health, and 2.45 times more in those with severe disabilities than in those without disabilities. The rate of depression decreased with education level, number of family members, and presence of children but increased with the presence of the disabled or elderly. Conclusion This study provides a comprehensive overview of depression among working-age household heads and identifies factors strongly associated with depression. These findings may have implications for policymakers to reduce the burden on and improve the quality of life of household heads.

Background: FISH can detect number and structural chromosome aberrations in DNA. FISH is new technique in Vietnam, we combine FISH with chromosome analysis to prenatal diagnosis Down syndrome and turner syndrome that are high rate in birth defect.Objectives: To detect Down syndrome and turner syndrome by using FISH technique with chromosome analysis from amniotic cell.Subjects and method: 14amniotic cells samples 15th - 20th week with high risk of birth defects. Advance using FISH and chromosome analysis from amniotic cell. Results: We obtained results as follow: - 14/14 samples: correspondence between FISH and chromosome analysis. \ufffd?Detected 2 Down syndrome (female. Trisomi 21) and 4 Turner syndrome (45, X). Conclusion: Detected Down syndrome and Turner syndrome by using FISH technique with chromosome analysis from amniotic cell.
Down Syndrome/ diagnosis ; Turner Syndrome/ diagnosis ; Predictive Value of Tests ; Prenatal Diagnosis ; In Situ Hybridization ; Fluorescence ;