Objective To explore the effect and mechanism of curcumin on rat cerebral ischemia reperfusion injury.Methods The rat model of cerebral ischemia reperfusion injury was constructed by the suture-occluded method.The effects of curcumin on cerebral infarction range,cerebral water content,neurological symptoms,cerebral histopathological morphology and expressions of PI3K,AKT,p-AKT,m-TOR,MDA,CAT,GPX,SOD,Bcl-2,Bax,Caspase-3 and Cleavage-Caspase-3 were evaluated.Results Cur-cumin had the protective effect on cerebral ischemia reperfusion injury,could alleviate the neurological symptoms,decreased the cer-ebral tissue pathological morphological changes and cerebral water content,in addition,which could alleviate the expressions of MDA,Bax,Cleavage-Caspase-3,IL-6,MCP-1 and TNF-αand increased the expressions of PI3K,p-AKT,mTOR,Bcl-2,Caspase-3, CAT,GPX and SOD.Conclusion The curcumin pretreatment has the significantly protective effect on cerebral ischemia-reperfusion injury,which may be associated with activating PI3K/AKT/mTOR signal pathway,while suppressing inflammation,apoptosis and oxidative stress.

Bronchopulmonary dysplasia remains the most common severe complication of preterm in-fants,affecting the quality of life in preterm children seriously. There is no specific or effective treatment availa-ble to date for BPD. Since the aetiopathogenesis of BPD is multifactorial,involving diverse molecular signaling pathways,a variety of biomarkers detected in biological fluids have been proposed for early identification of in-fants predisposed to BPD.

This article introduces the principle and the structure of streamline testing based on the newly developed laboratory automation system in our hospital.An overview of the functions and the technical structure of each module within streamline testing are provided.The streamline procedure and the information transmission between modules are also briefly described.

Since the China's new healthcare reform has launched , beneficial policies introduced by the central and local governments has promoted the rapid development of private hospitals .This paper taking Sichuan Province as an ex-ample analyzes the development of private hospitals from four points of view:hospital amount, scale, location and services package, using 2002—2014 hospital-level data, which provides decision support for formulating and improving relative pol-icies.As per the analysis of the data at hand , it has been confirmed that private sector has developed quickly during the 13 years, with the number of hospitals increasing by 19.2%annually.Private hospitals were mainly of small-scale.Although the proportion of services provided by privates sector has grown yearly , it was merely 14.5%in 2014.The hospital location that the private sector selected concentrated mainly in developed regions , but the proportion of private hospital in the un-derdeveloped region has risen steadily .In terms of types of service provided , there were certain differences between private and public sector.Compared to the public sector, the private sector provided a higher proportion of specialized medical services, concentrating on otolaryngology , cosmetic plastic surgery , cardiovascular services , etc.

Antibodies, Monoclonal ; immunology ; therapeutic use ; Antibodies, Monoclonal, Humanized ; Carcinoma, Squamous Cell ; drug therapy ; Cetuximab ; Head and Neck Neoplasms ; drug therapy ; Humans ; Receptor, Epidermal Growth Factor ; immunology

Objective To investigate the expression changes of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells in balloon injury of carotid artery in rat in order to explore the proliferation mechanism of vascular smooth muscle cells. Methods A rat model of vascular restenosis induced by injury to the carotid arteries due to balloon dilatation was reproduced in present study. A total of 18 SD rats were randomly divided into 3 groups (6 each): control group, 7-day group and 14-day group after balloon injury to the carotid artery. The expression of STIM1 mRNA in vascular smooth muscle cells was assayed with reverse transcription polymerase chain reaction (RT-PCR), and the STIM1 protein was assessed by immunohistochemistry. The histopathology of the arteries was examined after by HE staining. Results Intima area/media area ratio (IA/MA) was significantly increased in 7-day group after balloon injury than in control group (P

Objective To compare the effect of emergency percutaneous transluminal coronanry angioplasty and thrombolytic therapy (PTCA) in acute myocardial infarction (AMI). Methods 52 cases of AMI were treated by emergency PTCA while 58 cases of AMI were treated by thrombolytic therapy, we then compared the clinical effect between two groups both in hospital and the follow-up period. Results In the emergency PTCA group, 3 cases died while 49 cases were successful (success rate 94.2%) and the average staying in hospital was 14.6 d. In this group the left ventricular ejection fraction (LVFT) was 45.5%?4.3%. During the follow-up period of 2～18 months, 3 cases of angina pectoris occurred again and 3 case accepted the treatment of selective PTCA in the emergency PTCA group. In the group of thrombolysis, 8 cases died while 50 cases were successful (the ratio of success rate 86.2%) and the average staying in hospital was 26.4 d. In this group the LVFT was 37.6?6.2. During the follow-up period of 2～18 months, 17 cases of angina pectoris occurred again and 17 cases accepted the treatment of selective PTCA in the thrombolysis group. Conclusion The infarct related arteries (IRA) can be revascularized with emergency PTCA in AMI. The treatment of emergency PTCA can reduce the ratio of sudden death and the days in-hospital ( P

Objective:To study the dissolution behavior of panax notoginseng saponins R1 , ginseng saponin Rg1 and ginseng sapo-nin Rb1 in Xuesaitong soft capsules in two different dissolution media. Methods:The dissolution test conditions were confirmed accord-ing to“quality of medical drugs information set” of Japan and the dissolution media were chosen in accordance with the physicochemi-cal properties of Xuesaitong soft capsules, the in vitro dissolution of Xuesaitong soft capsules was inspected respectively in pH 6. 8 phosphate buffer and water. The dissolution rate was determined by HPLC-ELSD, and the similarity of the release curves for the three components was compared with similarity factors ( f2 ) method. Results: The assay displayed a good linearity over the concentration range of 0. 8-16. 0 mg·L-1(r=0. 999 6), 3. 0-60. 0 mg·L-1(r=0. 999 8) and 4. 0-80. 0 mg·L-1(r=0. 999 7) for panax notog-inseng saponins R1 , ginseng saponin Rg1 and ginseng saponin Rb1 , respectively. In pH 6. 8 phosphate buffer and water, f2 of ginseng saponin Rg1 and ginseng saponin Rb1 were both above 50 when compared with panax notoginseng saponins R1 . Conclusion:The meth-od is simple, accurate and reproducible in the dissolution determination of the soft capsules. The dissolution of ginseng saponin Rg1 and ginseng saponin Rb1 has similar characteristics with that of panax notoginseng saponins R1 in Xuesaitong soft capsules.

ObjectiveTo explore the effect of institutionalized humanistic care on relieving patients' anxiety.MethodsTotally 424 patients with anxiety in respiratory department were randomly divided into experiment group ( n=198 ) and control group ( n=226 ).The institutionalized humanistic care was used in experiment group accompanied by normal holistic nursing while only holistic nursing was used in the control group.The anxiety status of patients was evaluated by using the hamilton anxiety scale ( HAMA ) from admission to discharge.The relief of anxiety was compared in two groups.Results①The seores of two groups were decreased because of the intervention ( P ＜0.01 ).②The scores of anxiety in experiment group was lower than that in control group at discharge ( P ＜0.01 ).ConclusionThe anxious emotion of patients was relieved after the intervention in the hospital,however,institutionalized humanistic care is more effective in relieving anxiety in patients.

0.05). The titrimetric determination of standard solution containing different levels of chloride showed recovery rates of 98.0%～103.7%, relative standard deviation was 0.16%. Conclusion Automatic potentiometric titration was easy to grasp, rapid and accurate, which was a new analytical method worthy to be applied extensively.