Background: Tophi gout refers to the condition, where consistently high level of uric acid in the body causes the deposition of uric acid or monosodium urate crystals on the joints. Objective: To describe clinical and subclinical features of tophi gout. Subjects and method: A study conducted in 51 patients with tophi gout (according to Bennett-Wood criteria - 1968) in Department of Rheumatology, Bach Mai hospital, from February 2005 to February 2006. This was a cross-sectional prospective study. Results: The average time of tophi appearance lasted 5.3 \xb1 5.7 years. The average number of tophi was 4.5 \xb1 3.9. The most common positions of tophi were tarso - metatarsal - phalangeal joints and elbow joints (43-47%). 100% had gouty arthritis (in which 66.6% > 4 joints), 50-55% involved tarso - metatarsal - phalangeal joints (43.1% had deforming joints). On X-ray, 62.7% cases has injuries, para-articular erosions and overhanging margins (62.5%), joints space narrowing (71.9%), proliferation osseous change (43.8%). Renal stones examined by ultrasound were 41%, renal failure 24.6%. Blood analysis showed hyperuricemia (88.2%), hypertriglyceridemia (54.9%), hyperglycaemia (13.6%). Conclusions: Common features tophi gout were injuries in tarso - metatarsal - phalangeal joints; gouty polyarthritis over 4 joints. X-ray images showed para-articular erosions, joints space narrowing, proliferation osseous changes.
Gout/ pathology ; diagnosis

Background:Rheumatic heart disease is an acquired heart disease which often seen in the year of 90's. Nowaday, due to the development of health care system, population benefit much of knowledge to prevent this disease, the rate of prevenlence reduce significant. Objectives:This study aims to diagnose and prevent relapse in childen with rheumatic heart diseasewho treated in National Hospital for Pediatrict. Subjects and method:A retrospective study was conducted on 236 children with rheumatic heart diseaseor cardiac valve diseasewho admitted at Cardiology department of the National Hospital for Pediatrics from 1st January 2001 to December 31, 2005. Results:29.7% (70/236) were hospitalized for rheumatic valve disease. Among 166 hospitalized children due to continuous rheumatic heart disease, the result showed that: The types of carditis and arthritis were the most frequent and at least 22.9% (38/166) of children had definitive permanent valve lesions . 65.7% (44/76 responses) children received proper prevention. Some of them were not monitored at the center of prevention. The greater part of the rest had no knowledge of this disease. Conclusion:Rheumatic heart disease reduced but the prevalence of heart valve complication increased.\r\n", u'\r\n', u'
Rheumatic Heart Disease/ diagnosis ; therapy ; Infant

Background: Congenital heart disease is a malformation which the prevalence of 8 \ufffd?among alive infants. If it is not being treated on time, these malformations will develop to severe complication. The most common cause of cerebral abscess is congenital heart disease in infants. Objectives:This study aims to learn about some related factors and close consequence of cerebral abscess in congenital cardiac children. Subjects and method:A retrospective and prospective study was conducted on 37 patients with congenital heart disease were suffered from a cerebral abscess since January 2001 to 31 March 2007. Results:The boys were dominant with sex ratio: 1.85/1. Average age of acquired abscess was 6.8 years, 34/37 (91.9%) patients had curable congenital heart disease, including 33/37 (89.2%) diagnosed of right-left shunt. In comparison with patients whom over 2 years old and did not acquire abscess due to congenital cardiac shunt right-left type, there was no significant difference in hemoglobin, hematocrit, erythrocyte and saturation cutannee 13.5% among 37 patients of study were deaths, 26.5% had neurological sequelae and 8.1% were relapses. The average duration of hospitalization was longer (25.7 days) and the average costs were 4,317,000 Vietnam dong. Conclusion: Cerebral abscess was late complication of congenital heart disease and it was very necessary to treat completely the malformation of congenital heart disease in order to prevent of severe complication.
Heart Defects ; Congenital/ epidemiology ; therapy ; Brain Abscess/ epidemiology

Background: Wrist joint damage is early, common symptom and in diagnostic criteria of rheumatoid arthritis. Objective: to describe characteristics of MRI of the wrist in rheumatoid arthritis. Subjects and methods: This was a describe study. The study included 41 patients who were diagnosed rheumatoid arthritis according to the criteria of American College of Rheumatology- 1987 from January to October - 2006. Results: The average disease duration was 16.4 \xb114.71months. According to Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) 2002, damages on MRI included: 100% of patients had synovitis (5.9 \xb1 2.20), 100% of patients had bone erosions (15.3 \xb1 11.06) and 90% of patients had bone edema (7.3 \xb1 5.86), total score 28.6 \xb1 16.58. The correlative coefficient between synovitis and bone edema: r=0.43, P<0.01, between synovitis and bone erosions:r=0.61, P<0.01, between bone erosions and bone edema: r=0.55, P<0.01. MRI revealed bone erosions in 100% of patients having rheumatoid arthritis less six months after symptom onset compared with 0% of patients on radiography. In patients with over 2 years of disease duration, this rate on MRI was 100% of patients compared with 87.5% of patients on radiography. Conclusions: The specific damages of the wrist on MRI have value in diagnosis of early rheumatoid arthritis. \r\n', u'\r\n', u'\r\n', u'
Arthritis ; Rheumatoid ; Magnetic Resonance Imaging ;

Background: Fungal keratitis is a serious ocular infection that can cause corneal scarring and blindness. Currently, diagnosis of fungal pathogens remains a difficult problem. Objectives: To investigate the application of semi-nested PCR targeted ITS genes for detection of fungal agents causing keratitis. Material and method: Ten identified fungal strains, 4 bacterial strains, 20 scraping samples from patients with suspected fungal keratitis and 2 scraping samples from patients with suspected bacterial keratitis were tested using semi-nested PCR. Results: Semi-nested PCR showed positive results for the samples of identified fungal strains and for the 20 scraping samples from patients with suspected fungal keratitis. Neither samples of bacterial strains nor scraping samples from suspected bacterial keratitis patients gave positive PCR results. Conclusion: Semi-nested PCR is a robust tool for specific and rapid detection of fungal agents causing keratitis.
Fungal keratitis ; semi-nested PCR

Background: A/H5N1 influenza virus spreads from birds to humans and cause influenza diseases with high mortality rate. Vaccination is the most effective way to protect communities from pandemic, reduce morbidity and mortality. The study of creating A/H5N1 influenza vaccines in conformity with Vietnam was the urgent need. Institute of Vaccine\u2019s Achievement (IVAC) studied production of inactivated influenza vaccine for human on egg-grown from reassortants NIBRG-14. Objectives: In order to produce experimentally A/H5N1 influenza vaccine for human in accordance with WHO requirements and set up a viable process for production of the vaccines. Subjects and method: 10 days embryonated eggs and NIBRG-14 strains were served to the study with LAL method to check endotoxin, Kijehdal method to test total protein. Results: IVAC had produced successfully 5 lots of absorbed vaccine A/H5N1 (FLUVAC) using NIBRG-14 strains and embryonated eggs. Initially, production and quality control processes had been set up at IVAC by applying the recommendations of WHO. Conclusion: The success of the study was a basis of the approval of the government to establish a influenza vaccine manufacturing facilities.
Influenza A Virus ; H5N1 Subtype ; Influenza Vaccines ; Humans ; Eggs

Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET). Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam. Results: Of the 16,972 day 3 DET cycles investigated, 8,812 (51.9%) resulted in pregnancy. Of these, 6,108 cycles led to clinical pregnancy, with 1,543 (25.3% of clinical pregnancies) being twin pregnancies. Factors associated with twin pregnancy included age under 35 years (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.32 to 1.71; p<0.001) and cycles involving the transfer of at least one grade I embryo. Relative to the transfer of two grade III embryos, the risk of twin pregnancy was significantly elevated following the transfer of two grade I embryos (OR, 1.40; 95% CI, 1.16 to 1.69; p<0.001) or a combination of one grade I and one grade II embryo (OR, 1.27; 95% CI, 1.05 to 1.55; p=0.001). Conclusion By analyzing a large number of IVF/ICSI cycles, we identified several predictors of twin pregnancy. These findings can assist medical professionals in tailoring treatment strategies for couples with infertility.

Objective: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). Methods: This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. Results: Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41–1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. Conclusion HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations.

This paper describes progress on formulating a national asbestos profile for the country of Vietnam. The Center of Asbestos Resource, Vietnam, formulated a National Profile on Asbestos-related Occupational Health, with due reference to the International Labor Organization/World Health Organization National Asbestos Profile. The Center of Asbestos Resource was established by the Vietnamese Health Environment Management Agency and the National Institute of Labor Protection, with the support of the Australian Agency for International Development, as a coordinating point for asbestos-related issues in Vietnam. Under the National Profile on Asbestos-related Occupational Health framework, the Center of Asbestos Resource succeeded in compiling relevant information for 15 of the 18 designated items outlined in the International Labor Organization/World Health Organization National Asbestos Profile, some overlaps of the information items notwithstanding. Today, Vietnam continues to import and use an average of more than 60,000 metric tons of raw asbestos per year. Information on asbestos-related diseases is limited, but the country has begun to diagnose mesothelioma cases, with the technical cooperation of Japan. As it stands, the National Profile on Asbestos-related Occupational Health needs further work and updating. However, we envisage that the National Profile on Asbestos-related Occupational Health will ultimately facilitate the smooth transition to an asbestos-free Vietnam.
Asbestos* ; Asian Continental Ancestry Group ; Humans ; Japan ; Mesothelioma ; Occupational Health ; United States Agency for International Development ; Vietnam* ; World Health Organization