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During the past decade, major breakthroughs have been achieved in treatment of chronic hepatitis B. Currently, three therapeutic agents are approved for chronic hepatitis B: interferon-alpha, lamivudine and adefovir dipivoxil. In patients with HBeAgpositive chronic hepatitis B, all of these drugs achieve HBeAg loss (24-33%) and anti-HBe seroconversion (12-30%) rates that are superior to those observed in untreated controls. Interferon-alpha has several drawbacks, such as the parenteral administration and the development of frequent and potentially serious side effects. Lamivudine is a safe drug with rare and generally mild side effects. Lamivudine induces an initial virological remission in 70-90% of patients, but only 30-40% of patients remain in remission after the third year due to progressively increasing viral resistance. The main advantage of adefovir dipivoxil is the rare emergence of resistance, which has been identified in less than 2% of patients at 2 yr of treatment. Adefovir is also effective against lamivudine-resistant strains. This review will focus on the natural history and recently gained knowledge on the treatment of chronic hepatitis B.
Adenine/*analogs & derivatives/therapeutic use ; Antiviral Agents/*therapeutic use ; Hepatitis B/*drug therapy ; Humans ; Interferon-alpha/therapeutic use ; Lamivudine/therapeutic use ; Phosphonic Acids/therapeutic use ; Reverse Transcriptase Inhibitors/therapeutic use

8.Clevudine therapy in patients with chronic hepatitis B.

Kwan Sik LEE

The Korean Journal of Hepatology 2009;15(2):119-121

9.Advances in studies on effect superiorities of traditional Chinese medicine on chronic hepatitis B.

Shao-Li WANG ; Nai-Li YAO ; Wen-Liang LV

China Journal of Chinese Materia Medica 2007;32(23):2468-2470

Determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs is the characteristic of traditional Chinese medicines' treatment on chronic hepatitis B. There are important effects and special superiorities for traditional Chinese medicines on resisting hepatic fibrosis, improving liver function, protecting liver cells and relieveing the symptoms. The therapeutic effects about the only traditional Chinese medicine and traditional Chinese medicine added western medicine compared with the only western medicine was reviewed in order to explain the traditional Chinese medicine' s therapeutic superiorities.
Antiviral Agents ; therapeutic use ; Diagnosis, Differential ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B, Chronic ; diagnosis ; drug therapy ; Humans ; Lamivudine ; therapeutic use ; Medicine, Chinese Traditional ; Phytotherapy

10.Several important issues in the antiviral therapy of hepatitis B.

Yue-cheng YU ; Jin-lin HOU

Chinese Journal of Hepatology 2004;12(10):626-627

1.The Efficacy of Lamivudine in Korean Patients with Chronic Hepatitis B.

2.Problems of and strategies in nucleotide analogues therapy for chronic hepatitis B.

3.The use of nucleotide analogues in treating patients with chronic hepatitis B.

4.Treatment of chronic hepatitis B with integrative medicine.

5.The overview of the seminar on chronic hepatitis B.

6.Effects of lamivudine on cirrhotic patients following chronic hepatitis B.

7.Current Antiviral Therapy for Chronic Hepatitis B.

8.Clevudine therapy in patients with chronic hepatitis B.

9.Advances in studies on effect superiorities of traditional Chinese medicine on chronic hepatitis B.

10.Several important issues in the antiviral therapy of hepatitis B.

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