The oral carriage rate of Candida in healthy humans ranges from 40% to 60%. However for a prolonged period, the oral candidal prevalence in humans was documented essentially using data from studies in the West as their prevalence in inhabitants in different regions of the world, including Asia was not known. Yet, recent reports from a number of studies indicate the quality, quantity and prevalence of oral yeasts differ between Asia and other regions for reason that are still unclear. This mini review on such data from Asian studies on oral carriage of Candida provides another intriguing facet of the behavior of this ubiquitous yeast.
Areca ; Asian Continental Ancestry Group ; Candida ; classification ; isolation & purification ; Cohort Studies ; Colony Count, Microbial ; HIV Infections ; microbiology ; Humans ; Leprosy ; microbiology ; Mouth ; microbiology

Objective: Candidiasis is the most common fungal infection in human immunodeficiency virus (HIV) - infected individuals. As there is sparse data on the oral Candida species in HIV- infected individuals in India, we characterized Candida species from the oral cavity in two cohorts - with and without HIV infection and with presence or absence of clinical oral candidiasis, in Chennai, South India.
Methods: Saliva samples were collected from 147 consecutive study participants by the oral rinse technique. Candidal species were isolated by culturing specimens on Sabouraud‘s dextrose agar. The pure cultures so derived were speciated using the commercially available ID32C system, and the results were interpreted using APILAB plus software.
Results: In the HIV seropositive group, the most commonly isolated candida species was C.albicans (86%) followed by C.tropicalis (23%), C.guilliermondi (6%), C.krusei (5%) and others (4%). In the healthy cohort without clinical candidiasis, C.tropicalis was the most commonly isolated species.
Conclusion: There appears to be a marked variation in oral Candida species found in HIV-seropositive and seronegative individuals in India. To our knowledge, this is the first attempt to identify oral Candida species in a South Indian population.