Antiviral Agents ; administration & dosage ; therapeutic use ; China ; Hepacivirus ; Hepatitis C ; drug therapy ; Humans

spective application of detection of HBV virological and serological markers, and their use in clinic.

Antiviral Agents ; administration & dosage ; therapeutic use ; Drug Therapy, Combination ; Genotype ; Hepatitis B virus ; drug effects ; Hepatitis C, Chronic ; complications ; drug therapy ; Humans ; Interferon-alpha ; administration & dosage ; therapeutic use ; Liver Cirrhosis ; drug therapy ; etiology ; Polyethylene Glycols ; administration & dosage ; therapeutic use ; Protease Inhibitors ; administration & dosage ; therapeutic use ; RNA, Viral ; blood ; Ribavirin ; administration & dosage ; therapeutic use ; Treatment Outcome

Animals ; Cell Differentiation ; Hepatocytes ; cytology ; Humans ; Liver Diseases ; therapy ; Liver Regeneration ; physiology ; Research ; trends ; Stem Cell Transplantation ; Stem Cells ; cytology

Over the last several decades, the government’s health decision-making consciousness has change as result of huge economic and social changes thereby resulting in obvious volatility in the continuity of health service de-livery from China’s rural health service network:In the planned economy era. , the rural service mode of“classifica-tion and division of medical institutions and local doctors for local patients” was a starting point for the initial practice of health services continuity;however, following market reforms, rural China has adopted a discrete service mode of“patients freely choosing their doctors, and a fragmentation of provision”;after 2009, with the implementation of the equalization of primary public health service, rural health services exhibited a development trend towards a service mode of “medical treatment at primary health institutions, continuity and comprehensiveness of service provisions”. The volatility of service provision modes in the above three stages indicates a deep influence on the government’s un-derstanding of health service governance at different periods and fully demonstrates that primary care services have ob-vious political vulnerability. These policy motivations behind the characteristics of historical evolution provide many policy experiences of enlightenment for all countries, particularly for the health networks of transitioning nations. To maintain health service continuity, importance must be attached to basic health care strategies, a complete, integrat-ed grassroots health system framework and systematic operation mechanisms must be established and attention must be given to the service concept of people-centered services.

Hepacivirus ; Hepatitis C ; Humans

Asia ; epidemiology ; Humans ; Non-alcoholic Fatty Liver Disease ; epidemiology ; Prevalence

Antiviral Agents ; administration & dosage ; therapeutic use ; Hepatitis C ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy

Both long term follow up and real world research on chronic hepatitis B have accumulated data on nucleos (t) ide analogues in anti-HBV treatment,which shows that resistance mutation turns out to be the major obstacle in achieving response.Identification of genotypic resistance at early stage is key to improve strategy.Deep-sequencing will be helpful to predict resistance earlier.Direct acting autiviral agents on hepatitic C virus tell us resistance at the very beginning,however,more data is still needed to elucidate how to use resistance monitoring of anti-HCV treatment.

Objective To explore the protective effects of puerarin on CCl 4-induced acute hepatic injury of rats. Methods Acute hepatic injury model was induced by CCl 4. Before and after low-dose (40 mg/kg) or high-dose (200 mg/kg) of puerarin was given, the levels of AST, ALT in serum, and liver index, and SOD activity, MDA content in serum and liver tissue were measured. Liver pathological changes were also observed. Results Puerarin reduced the serum levels of AST, ALT obviously (P