Objective: to study the ability of cedemex in preventing the spirit dependence (anti readdiction). Animals and method: using the method of position taste with condition to establish the model of spirit dependence to morphine in white house- mouse. Results: Among the mice taking continuously cedemex by 5 days, with 3 different doses, then using hydrocortisone to stimulate, the residence time in white boxes did not last clearly, the behaviour toward preferring white boxes was not recovered and it returned to position state without condition. But in morphine group when using NaCl 9%o, the residence time in white boxes did last clearly, the behaviour toward preferring white boxes was recovered.
Morphine ; Therapeutics

81 children with three age group of 9, 12 and 14 in Th¸i Nguyªn received the cardiac ultrasound to evaluate the major parameters. The results have shown that cardiac size was gradually increased as increased age. The changes of cardiac size was correlated closely with the body weight in some parameters including the left cardiac ventricular diameter in the end of diastolic stage (Dd) and of systolic stage (Ds), the posterior wall thickness of left ventricular in the end of systolic stage (LWS)) and inter ventricular septal thickness.
ultrasonography, child

Study on 200 patients with hypertension in Th¸i Nguyªn Central General Hospital during 1997-1998 by the clinical and paraclinical methods have shown that the rate of hypertension is increasingly as increased age, most common in ages of 41-70, who are on activities, male, nervous activities and Kinh nation, habit of use of much salt and use of stimulators such as wine, cigarettes were risk factors.
Hypertension ; Risk Factors

OBJECTIVETo investigate the effect of Cedemex on cAMP and cGMP contents in different brain regions in morphine withdrawal rats precipitated by naloxone.

METHODA physical morphine dependent model of rats was established by subcutaneous injection of morphine in gradually increasing dosage within 7 days. cAMP and cGMP contents of VTA, cortex and hippocampus of the rat brains were determined by radioimmunoassay.

RESULTThe morphine withdrawal symptoms of rats were relieved significantly by ig Cedemex. Compared with the controls, cAMP content in the region of VTA, cortex and hippocampus of the morphine dependent rats were significantly higher (P < 0.05), while cGMP contents in those regions were significantly lower (P < 0.05). cAMP contents in the area of VTA, cortex and hippocampus of the morphine dependent rats were significantly reduced, while cGMP contents were significantly increased by ig Cedemex.

CONCLUSIONCedemex may significantly attenuate the morphine withdrawal symptoms in rats. The mechanism of this effect may be related to adjusting the contents of cAMP and cGMP in some brain regions.

Animals ; Brain ; drug effects ; metabolism ; pathology ; Cerebral Cortex ; drug effects ; metabolism ; Cyclic AMP ; metabolism ; Cyclic GMP ; metabolism ; Drugs, Chinese Herbal ; pharmacology ; Hippocampus ; drug effects ; metabolism ; Morphine ; adverse effects ; Rats ; Substance Withdrawal Syndrome ; metabolism