Animals ; Antigen-Antibody Complex ; analysis ; DNA ; immunology ; DNA, Protozoan ; immunology ; Female ; In Situ Hybridization ; Lupus Nephritis ; etiology ; Mice ; Mice, Inbred BALB C ; Trypanosoma ; genetics

Objective To evaluate the short-term efficacy and toxicity of the combination of gimeracil and oteracil porassium ( S-1 ) and cispla-tin in the treatment of advanced gastric carcinoma.Methods Fifty-six patients with advanced gastric carcinoma were randomly divided into two groups with 28 cases in each group.Experimental group was treated with S-1 (60 mg bid d1 -d21) combined with cisplatin (60 mg· m-2 iv d1-d3) with 4 weeks as a cycle.While control group was treated with oxaliplatin (130 mg· m-2 iv d1), tegafur (600 mg· m-2 iv d1-d5), calcium folinate ( 120 mg · m-2 iv d1 -d5 ) with 3 weeks as a cycle.Short-term efficacy and adverse reactions were evaluated after three cy-cles.Results The tumor response rate of experimental group and control group was 75.0%and 42.9%(P<0.05).Besides, compared with the con-trol group , the occurrence of gradeⅢ-Ⅳadverse reactions in experimental group were apparently lower.Conclusion The regimen of S -1 combined with cisplatin has shown a better efficacy in the treatment of patients with ad-vanced gastric carcinoma , and the toxicity is relatively mild and tolerable .