Virilization in female newborns as a result of an ovarian mass known as luteoma of pregnancy is a rare condition. A case of a maternal pregnancy luteoma responsible for virilization of both newborn and mother is reported. Luteoma of pregnancy, first described by Sternberg in 1963, is usually asymptomatic and is discovered incidentally during a cesarean section or postpartum tubal ligation. To date, fewer than 200 cases have been reported in the literature. This report describes a case of a virilized pregnant woman first seen in active labor who eventually underwent cesarean section for arrest of descent. Intraoperative findings showed a well circumscribed, pedunculated mass attached to the left ovary. A healthy baby girl was born with masculinization of the external genitalia.
LUTEOMA OF PREGNANCY ; EXTERNAL GENITALIA

Female ; Humans ; Luteoma ; pathology ; Ovarian Neoplasms ; pathology ; Pregnancy ; Pregnancy Complications, Neoplastic ; pathology

We report here on a 26-year-old pregnant female who developed hirsutism and virilization during her third trimester along with a significantly elevated serum testosterone level. Abdominal US and MR imaging studies were performed, and they showed unique imaging features that may suggest the diagnosis of pregnancy luteoma in the clinical context. After the delivery, the serum testosterone level continued to decrease, and it returned to normal three weeks postpartum. The follow-up imaging findings were closely correlated with the clinical presentation.
Adult ; Contrast Media ; Diagnosis, Differential ; Female ; Gadolinium DTPA/diagnostic use ; Hirsutism/etiology ; Humans ; Luteoma/complications/*diagnosis ; Magnetic Resonance Imaging ; Ovarian Neoplasms/complications/*diagnosis ; Pregnancy ; Pregnancy Complications, Neoplastic/*diagnosis ; Pregnancy Outcome ; Ultrasonography, Prenatal ; Virilism/etiology

No abstract available.
Acne Conglobata ; Acne Vulgaris ; Luteoma ; Skin Manifestations ; Skin

Ovarian steroid cell tumors are composed exclusively of cells that have the histologic features of steroid hormone secreting cells. And these are rare lesions and have been divided into four subtyes according to their size, location in the ovary, and presence or absence of crystals of Reinke in the cytoplasm as follows: stromal luteomas, hilus cell tumors, Leydig cell tumors (non-hilar type), and steroid cell tumors not otherwise specified. Steroid cell tumors often secret androgens, and manifest themselves with symptoms of virilization. Other presenting manifestations include hirsutism, amenorrhea, obesity, hypertension and alopecia. We experienced a case of ovarian steroid cell tumor, manifested by obesity and amenorrhea and present with a brief review of the literatures.
Alopecia ; Amenorrhea ; Androgens ; Cytoplasm ; Female ; Hirsutism ; Hypertension ; Leydig Cell Tumor ; Luteoma ; Obesity* ; Ovary ; Virilism

Steroid cell tumors account for less than 0.1% of all ovarian tumors. There are three steroid cell tumor subtypes: steroid cell tumor not otherwise specified (NOS), stromal luteoma and Leydig cell tumor. Steroid cell tumor, NOS, is the most common type and has malignant potential. This report describes a case of an ovarian steroid cell tumor, NOS. A 35-year-old woman visited hospital with the complaint of metrorrhagia. Physical examination revealed increased pubic hair. Transvaginal ultrasound indentified a 4.9 x 3.4 cm, well-circumscribed and solid left ovarian tumor. After laparoscopic left oophorectomy, the tumor was revealed as an ovarian steroid cell tumor, NOS. During the laparoscopic surgery, tumor ruptured. Complete surgical staging was performed and no evidence of metastasis was found. Gonadotropin releasing hormone agonist was administered monthly for 6 months. The patient has had no evidence of recurrence for 43 months.
Adult ; Female ; Gonadotropin-Releasing Hormone* ; Gonadotropins ; Hair ; Humans ; Laparoscopy ; Leydig Cell Tumor ; Luteoma ; Metrorrhagia ; Neoplasm Metastasis ; Ovarian Neoplasms ; Ovariectomy ; Ovary ; Physical Examination ; Recurrence ; Sex Cord-Gonadal Stromal Tumors ; Steroids ; Ultrasonography