Abstract: ， Mass spectrometry technology has the advantages of high sensitivity high resolution and low detection limit. It is - ， widely used in the field of occupational health for rapid on site detection and accurate laboratory detection of workplace air ， ， biomarkermonitoring metabolomicsandproteomics andmore.Massspectrometrytechniquehasirreplaceableadvantagesover-- traditional technical means. It is applied to the rapid detection of workplace occupational disease inductive factors and ， laboratoryevaluation.Analysisontheaccuratedetectioncaneffectivelyidentifiedthekeyfactors.However theexistingstudies ， are mostly limited in basic research with few in the promotion and application in laboratory. The current occupational health researchhasonlyeightnationalstandardsrelatedtomassspectrometry.Itisurgenttoissuemorenationalstandardsusingmass-，spectrometryforpoisondetection.Massspectrometryisappliedtothehighthroughputanalysisofbiomarkersmetabolitesand，，proteinswhichcanbeusedtoevaluatetheextentofhumanexposureandpossiblepotentialhealtheffects.Howeverthe，existingstudiesaremostlyconfinedtothelaboratoryandthereisalackoffurtherconfirmationofpossiblebiomarkers.Atthe，sametimetheexistingmassspectrometryanalysismethodsaremostlyusedincombinationwithspectralandchromatographic，-，methodswhichhavesomelimitationsintherapidinsituanalysisoftoxicants.Thereforeanopenatmosphericpressureion，--sourcecanbeintroducedtoachievedirectonlineandinsituanalysisofsamples.