The role of bulletin in subject information service was analyzed, followed by a description of the con-tents, columns, topic selection standards and principles in Bulletin of Global Pharmaceutical Innovation, and a summary of the experiences in subject service through the bulletin.

"Hectic fever"is one kind of traditional Chinese medicine symptoms that call be Seen in marlv diseases and usually occurs in the afternoon during 3 to 5 PM.With constant clinical practices,doctors have proved that hectic fever can be induced by excess syndrome of Yang Ming Fu-organ,deficiency of blood and body fluid,stagnation of blood stasis,repression of qi activities due to humid heat,and floating of deficient yang qi.Therapies are divergent according to different pathogenesis.Clinically we should make the identification of etiology according to differentiation of symptoms and signs.grasp the essential pathogenesis and fully play the characteristics of TCM in treating based on syndrome differentiation and treating the same disease with different methods.

Objective To enhance the application of WLAN technology in hospital information construction.Methods Solving methods were proposed to the problems in application so as to enhance the awareness of safety.Results By analyzing and solving problems,WLAN was used in hospital more safely.Conclusion The ensurance of wireless network security can impel a safe and positive application of wireless network in the hospital information field as the reasonable development of the existing network.

Objective To investigate the efficacy and safety of atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris.Methods 90 elderly patients with angina pectoris were randomly divided into the observation group and control group,45 cases in each group.All patients were given conventional treatment and atorvastatin,the observation group was given clopidogrel based on this.The TC,TG,HDL-C,LDL-C,angina attack frequency,duration and adverse reactions,adverse cardiac events of two groups before and after treatment were compared,and the clinical effect was evaluated.Results The total effective rate of the observation group was 9 3.3 ％ (42/45),whichwassignificantlyhigherthan75.6％ (34/45) inthecontrolgroup (x2 =5.67,P ＜ 0.05).After treatment,the TC,TG,HDL-C,LDL-C of two groups were significantly improved than before treatment (t =5.34,4.78,4.56,4.92,4.31,3.92,4.11,4.62,all P ＜ 0.05),the improvement in the observation group was significantly better than that in the control group (t =4.20,4.08,3.98,4.03,all P ＜ 0.05).After treatment,the angina attack frequency and duration of two groups were significantly decreased compared with before treatment (t =6.22,5.78,4.12,4.02,all P ＜ 0.05),and the observation group decreased significantly than the control group(t =4.23,3.99,all P ＜ 0.05).3 cases of adverse reactions and 1 case of adverse cardiac events occurred in observation group,2 cases of adverse reaction and 3 cases of adverse cardiac events occurred in control group.Conclusion Atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris can regulate blood lipid and improve the symptoms of angina pectoris.

Objective　To evaluate the effects of meglumine diatrizoate mucilage (MDC) used as contrast medium in bronchography. Methods A total of 500 patients undergoing bronchography were reviewed, including male 346, female 154, with an average age of 42 (ranged 5～71). Among them, 415 were examined with bilateral bronchography in a dose of 20～30 ml, 85 with unilateral bronchography in 10～15 ml of MDC. Results　In 487 cases (97.4%), the lobes, segments, subsegment bronchi were revealed very well, and 456 cases (91.2%) had no cough. Conclusion　MDC is regarded as an ideal bronchial contrast medium, and may replace dionosil and iodized oil.

ObjectiveTo summarize the experience in diagnosis and treatment of malignant change in choledochal cyst patients in the past 20 years. MethodsThe clinical data of 16 patients admitted from 1980 to 2000 were analyzed retrospectively. Results9 patients had had a previous internal drainage procedure,12 patients had biliary tract infection, 4 cases presented with abdominal masses. All suffered body weight loss and general malaise. ERCP was performed in 5 cases with no previous operation, in which abnormal pancreatobiliary duct junction was found in 4 patients. Laparotomy plus metastatic lymph node biopsy was performed in 4 patients, choledochotomy with T-tube drainage for 4 patients, cyst excision and pancreatoduodenectomy for 3 cases, partial cyst excision with left lobectomy for 2 patients, cyst excision with Roux-en-Y hepaticojejunostomy for 3 patients. Pathology proved carcinoma was located in cyst wall in most cases.Postoperative survival time ranged from 4 to 31 months with a mean of 12.7 months. ConclusionsThe clinical symptoms of malignant change in congenital choledochal cyst were non-specific. The preoperative diagnosis for canceration was difficult, and the prognosis was poor.Total extrahepatic choledochocele resection should be adopted for the prevention of canceration.Intraoperative frozen section is helpful to confirm diagnosis. Cyst excision with pancreatoduodenectomy is the treatment of choice for carcinoma invading pancreatic head.

BACKGROUND: The intraocular lens can move forward during cataract optic capsular surgery,but the changes in the human eye diopter cannot be monitored in such a dynamically adjustment process,it is difficult to obtain clinical data which could reveal the correlation between intraocular lens forward and human eye diopter adjustment.OBJECTIVE: To observe the influence of intraocular lens movement on the adjustment of human eye diopter.METHODS: Based on Hwey-Lan Liou eye model,using optical design software ZEMAX to realize ray tracing,the relationship of intraocular lens forward in the eye with the adjustment of human eye diopter was investigated.RESULTS AND CONCLUSION: Once the intraocular lens forward for a certain distance,human eye obtained the amount of accommodating diopter was not constant; the adjustment amount depended on the axial length and the required intraocular lens implantation,especially in axial length; for the intraocular lens forward of the surgical eyes at different axial lengths,the amount of accommodating human eye diopter was negatively correlated with axial length.

Objective To understand the molluscicidal effects of water extract of Ginkgo biloba's peel on Oncomelania hupensis Methods Immersion methods with a series of six concentrations from 0.3 percent to 3 percent were used to determine the molluscicidal effect. Results The LC 50 of the water extract of 1.0 percent was 28.8 mg/L for 24 hours immersion,12.6 mg/L for 48 hours,and 0.48 mg/L for 72 hours, respectively. The LC 50 of the extract of 2 percent was 19.9 mg/L for 24 hours,11.2 mg/L for 48 hours and 0.48 mg/L for 72 hours,respectively.The LC 50 of the extract of 3 percent was 19.1 mg/L for 24 hours,10.9 mg/L for 48 hours and 0.48 mg/L for 72 hours,respectively. The higher of the concentration, the better of the effect. Meantime, it's poisoning to crops and fishes was very low. Conclusion Ginkgo biloba's peel has molluscicidal effect. It is a good candidate of potential plant molluscicides.

Colorectal cancer is one of the most common malignant tumors of digestive system.There are significant differences between young patients and other ages in aspects of the disease features, biological characteristics, risk factors, clinical treatment and prognosis, etc.And the analysis of young colorectal cancer patients′ characteristics can provide new ideas for clinical treatment.

Objective To investigate the changes of left atrial(LA) segmental strains by using threedimension speckle tracking imaging(3D-STI),and to investigate the feasibility of 3D-STI for assessment of LA myocardial strains in healthy adults.Methods A total of 60 healthy subjects were enrolled.Apical fullvolume images were acquired in all subjects and then were analyzed by off-line 3D-STI analysis software.The software divided LA into 16 segments automatically,they were six walls (anterior,anterior-septal,posterior-septal,inferior,anterior-lateral,posterior-lateral) in basal and middle levels,and four walls (anterior,septal,inferior,lateral) in roof level.The peak longitudinal strain (PALS),peak circumferential strain(PACS),peak area strain(PAAS),the time to peak longitudinal strain(TPLS),the time to peak circumferential strain(TPCS) and the time to peak area strain(TPAS) of left atrial by 3D-STI were obtained and compared.Results ①Compared with the four walls in roof level and anterior-lateral,posterior-lateral walls in middle level,PALS of corresponding walls in basal level were significantly increased (P ＜0.05).PALS of posterior-septal,inferior and posterior-lateral walls in middle level were significantly increased than septal,inferior,and lateral walls of roof level (P ＜0.05).PACS and PAAS of all walls in roof level were significantly increased,as compared with that of corresponding walls in middle and basal levels,and the PACS of posterior-septal wall in basal level were lower than that in middle level(P ＜0.05).②There were no significant differences in PALS,PACS,PAAS between different walls within one level(P ＜0.05).③TPLS,TPCS,TPAS of septal wall were significantly lower than that of lateral wall.TPLS of anterior wall,TPCS and TPAS of inferior wall were significantly lower than that of lateral wall(P ＜0.05).Conclusions 3D-STI is a feasible skill to assess LA myocardial strains in healthy subjects.