Objective:To investigate the effect of liver ultrasonography and the security to rabbits with hydrogen peroxide(H 2O 2) affused by rectum.Methods:48 rabbits were divided into 4 groups according to different H 2O 2 concentrations,and each group was divided into 4 groups according to different H 2O 2 dosages. Each rabbit was affused with H 2O 2 by rectum,then the effect of liver ultrasonography was observed,and the damages to the tissues of rabbits were pathologically checked.Results:The liver structure could be clearly developed with 1% H 2O 2 10ml affused,and the liver gray value increased with the H 2O 2 concentration increased.The time from affusion to develop was shortened and the duration of high echo was prolonged.But at same H 2O 2 concentration,the time to develop was not significantly different with the H 2O 2 dosage increased,and the high echo was decreased more slowly.The average survival time of rabbits was significantly negatively correlated to the H 2O 2 concentration(?=-0.99),while the damage degree was significantly positively correlated (?=+0.99).Conclusion:H 2O 2 affusion can induce damage to tissues and microcirculation,while produce better liver ultrasound image,so it is important to chose suitable H 2O 2 concentration and dosage,to extend its clinical application.

OBJECTIVE:To study the stability of Ondansetron hydrochloride glucose injection(OHGI).METHODS:The contents of Ondansetron hydrochloride and its related substances were determined with HPLC.The stability of the samples were tested by high-light exposure,accelerating experiment and room temperature storage.RESULTS:After exposure to high light,the content in OHGI slightly decreased but on other experiments,it was rather stable.CONCLUSION:This injection should be kept away from high light and may be stored for2years at room temperature.

Objective:To study the mental health status of middle school students in Three-Gorges area of Chongqing in order to provide theory support for mental health education. Methods:1 014 middle school students in Three-Gorges area were tested by SCL-90. Results:The occurrent rate of mental problems with students was 19.8%,of which the first three factors were hostility,compulsiveness and interpersonal sensitivity. Girls’ overall score and mean scores of interpersonal sensitivity, depression,anxiety and phobic anxiety were significantly higher than boys’. The overall score and factor mean scores of senior high school students were significantly higher than those of junior high school students’ except hostility and phobic anxiety factors. The mean scores of interpersonal sensitivity,hostility and phobic anxiety factors were significantly higher than the counterparts in the norms of middle school students,while the mean scores of somatization and anxiety factors were significantly lower than the counterpart in the norms of middle school students. Conclusion:The mental health status of middle school students in Three-Gorges area of Chongqing is poor,and mental health education should be enhanced by all of us.

After a description of the concept and characteristics of metaliteracy, the main institutions shouldering the task of metaliteracy education were summarized, including government and fund organizations, faculties, scien-tific research office, and teaching group. Of these institutions, library plays a major role in metaliteracy education since it is not only the main driving force of metaliteracy education and the institution to make,file and maintain the resources for metaliteracy education, but also is the organizer, coordinator and manager of metaliteracy teachers.

Objective To observe safety and effectiveness of Dezocine in postoperative analgesia of pediatric tonsillectomy and adenoidectomy by the continuous intravenous infusion of different doses,and to explore appropriate dosage of Dezocine for pediatric postoperative analgesia.Methods Elective tonsillectomy and adenoidectomy require-ments of postoperative analgesia in children 120 cases,they were randomly divided into A,B,C,D groups of 30 cases by using number table.After surgery patient -controlled intravenous analgesia(PCIA)two days,A,B,C groups were given Dezocine 0.2,0.3,0.4mg·kg -1 ·d -1 continuous intravenous infusion,D group received Sufentanil 1μg· kg -1 ·d -1 continuous intravenous infusion.Observed and recorded pain scores and sedation scores for postoperative 6h,12h,24h and 48h;recorded adverse reactions,pressing the number and effective pressing times of children within 48h after surgery.;recorded overall evaluation of postoperative analgesia of children and parents.Results A group at each time point pain score was significantly higher than B,C,D three groups,the difference was statistically significant (tAB =12.003,PAB =0.049;tAC =7.542,PAC =0.036;tAD =40.990,PAD =0.009);A,B,C three groups at each time point sedation score was significantly lower than D,the difference was statistically significant(tDA =3.894,PDA =0.030;tDB =5.020,PDB =0.039;tDC =36.103,PDC =0.016);D group of adverse reactions were significantly higher than A,B,C three groups,the difference was statistically significant(χ2DA =20.738,PDA =0.000,χ2DB =4.35,PDB =0.029,χ2DC =5.98,PDC =0.025);A group within 48h postoperative analgesia press times and the number of valid pressing were significantly higher than B,C,D three groups,the difference was statistically significant(tAB =3.003, PAB =0.036;tAC =5.720,PAC =0.031;tAD =37.157,PAD =0.015);B,C two groups of children and parents to evaluate postoperative analgesia overall satisfaction rates were 90.0%,93.3%,significantly higher than A 63.3%,D 60.0%,and the difference statistically significant (χ2AB =5.310,PAB =0.031;χ2DC =19.640,PDC =0.000). Conclusion Dezocine 0.3mg·kg -1 ·d -1 continuous intravenous infusion for pediatric tonsillectomy and adenoid-ectomy is safe and effective in postoperative analgesia and fewer adverse reactions,and should be promoted.

Objective To explore the clinical efficacy of cetuximab combined FOLFOX chemotherapy on colon and colorectal cancer.Methods Forty patients with colon and colorectal cancer were randomly divided into observation group and control group,and 20 cases for each group.Patients in control group were treated with oxaliplatin + leucovorin + 5-fluorouracil,and in the observation group were given cetuximab (the first does was 400 mg/m2 at the first week,then the second week and follow weeks was 250 mg/m2 1 time/week for 6 week) plus the treatment as control group.The clinical efficacy,adverse effect and 1-year survival in the two groups were recorded.Results The total effective rate and clinical benefit rate in observation group were 60％ (12/20)and 85％ (17/20) respectively,which significantly higher than the control group (30％ (6/20) and 65 ％ (13/ 20),x2 =18.18,10.67,P ＜ 0.05).Skin rash rate in observation group was 55％ (11/20),which was significantly higher than that of control group (15％ (3/20),x2 =35.16,P ＜0.05).Half-year survival rate and 1-year survival rate of patients in observation group were 75％ (15/20) and 45％ (9/20) respectively,significantly higher than the control group (50％ (10/20) and 25％ (5/20),x2 =13.33,8.791,P ＜ 0.05)~ Conclusion Treatment scheme of Cetuximab combined FOLFOX chemotherapy is proved to be an effect of treating advanced colon and colorectal and be with the low adverse effect.

Autonomic nervous system(ANS) activity plays an important role in the pathogenesis of cardiovascular disease,including organic cardiovascular disease(such as hypertension,coronary artery disease,etc) and functional cardiovascular disease (such as vasovagal syncope,postural orthostatic tachycardia syndrome,etc).Many methods was used to evaluate ANS function.Heart rate variability is a widely accepted method to assess cardiac autonomic nerve function.Autonomic nervous affected cardiac action potential and let electrocardiogram changes.Through the sympathetic and parasympathetic neurotransmitters which acting on the corresponding receptors.Electrocardiogram changes reflects autonomic nervous function.Present researches suggest that electrocardiogram has an important significance in the evaluation of autonomic nerve function in functional cardiovascular disease.

Objective To investigate the clinical features of children with systemic lupus erythematosus (SLE).Methods Ninety-five patients hospitalized in Wuxi Children's Hospital from Jan.2003 to Dec.2013 were analyzed retrospectively.They were diagnosed as SLE for the first time.The clinical features of SLE between boys and girls were compared.Chi-square test was used for statistical analysis.Results Of the 95 cases with SLE,12 were boys and 83 were girls.Clinical manifestations showed 69 cases with facial rash (72.6％),43 cases with fever (45.3％),31 cases with arthritis (32.6％),24 cases with serositis (25.3％),23 cases with oralulcer (24.2％),13 cases with allergy to sunlight (13.7％),11 cases with nervous system damage (11.6％).Laboratory examination:94 cases (98.9％) with anti-nuclear antibody positive,91 cases (95.6％) with decreased C3 complement,71 cases (74.7 ％) with anti-dsDNA antibody positive,71 cases(74.7％) with decreased C4 complement,69 cases(72.6％) with anti-SSA antibody positive,62 cases (65.3％) with anti-Sm antibody positive,52 cases (54.7％) wiht proteinuria,anti-SSB antibody positive 49 cases(51.6％),46 cases (48.4％) with decreased leukocyte,38 cases(40.0％) with anti-nucleosome antibody,38 cases (40.0％) with anemia,26 cases(27.4％) with hematuresis,14 cases(14.7％) with decreased platelet,6 cases(6.3％) with injury of renal function.Renal injury,anti-Sm antibody and anti-nucleosome antibody of male children with SLE were significantly higher than those of female children(x2 =9.989,4.224,4.070,all P ＜ 0.05).The positive rate of anti-SSB antibody in female children with SLE was significantly higher than that of male children(x2 =3.885,P ＜ 0.05).Conclusions Male childre with SLE are easy to appear the renal injury,proteinuria is the most common.Anti-Sm antibody is a risk factor for the high incidence of renal injury in male children with SLE.Anti-nucleosome antibody is a risk factor for the high incidence of SLE disease activity in male children than that of female children.The risk of future Sjogren's syndrome in female children with SLE is higher than that of male children.

By using questionnaire method,We sent the questionnaires to 74 winners and 15 jury members of CMA-L'OREAL China skin/hair grant and analyzed the questionnaires that had been filled out by them.We got a better understanding on the issue of paper publications of the funded projects,and the judges,advices and overall feelings of winners and jury members on the grant.We analyzed why the grant has been highly appraised by the dermatologists,how the grant has promoted the research activities in the specific area,and what we should do to improve the grant management in the future.