Glycogen storage diseases (GSD) are a group of inherited disorders characterized by enzyme defects that affect the glycogen metabolism. Hypoglycemia, hepatomegaly, splenomegaly and growth retardation are the main clinical manifestations. The enzymes affecting glycogen synthesis and degradation are varied.Consequently, the clinical manifestations are different because of different enzyme defection. Most patients treated regularly can obtain the normal growth and grow to adults, but still can be accompanied long-term complications by adulthood. Now some scientists find new modified cornstarch is superior to standard therapy in maintaining blood glucose levels. Gene therapy is still in the experimental animals.

Triple negative breast cancer(TNBC) is defined by the lack of estrogen receptor (ER) , progesterone receptor (PR) and human epidermal growth factor receptor-2 ( Her-2) expression. It is a subtype of tumor with distinct clinical and pathologic features and lacks effective targeted therapies. It is non - sensitive to endocrine therapy and targeted therapy drug herceptin, leaving chemotherapy as the mainstay of treatment The feature and the treatment of TNBC is the hotspot of resent research.

According to the records in Neijing (Internal Classic), this article discusses the relationship during the connotative evolution of mai (vessel) and jing (meridian) in the three aspects, named mai (vessels), the evolution from mai (vessel) to jing (meridian), and the connotation replacement of jing (meridian) with mai (vessel). The study results show that the connotation of Jingmai is originated from mai (vessel), but more enriched, which cannot be confused with each other. The recognition on the connotation of jingmai from mai (vessel) to jing (meridian) is the process of TCM understanding from concretization to abstraction, and from the entity to the concept. Jing (meridian) represents the law on the longitudinal and invariable running course of meridian, differenti from the perspective in western medicine in human body. This law results from the naive observation and is based on the rational summary and thinking, and it stands up the approval from practice. The description of jing (meridian) as mai (vessel) is just the superficial description of this term. In fact, its concept infers to the connotation of meridian.
China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians ; Qi ; history

Acupuncture Points ; Acupuncture Therapy ; Adult ; Headache ; therapy ; Humans ; Male ; Pain, Intractable ; therapy ; Scalp ; Treatment Outcome

OBJECTIVETo explor the curative effect of double pedicle sliding skin flap for correction of cryptotia.

METHODSFrom January 2011 to October 2014, 7 cases with cryptotia (12 ears) were treated. We designed a double pedicle sliding skin flap above the helix. The flap was slided downward to form a new auriculocephalic sulcus. The other wound was covered by skin graft.

RESULTSAll wounds healed very well with no complication. The follow-up period ranged from 3 months to 1 year, with an average of (5.67 ± 3.38) months. The ear had stable appearance with no recurrence. The result was satisfactory.

CONCLUSIONSThe method is simple with reliable flap survival rates. The new auriculocephalic sulcus is stable and resistant. It's a good choice for correction of cryptotia.

Ear Auricle ; abnormalities ; surgery ; Ear Cartilage ; abnormalities ; surgery ; Follow-Up Studies ; Graft Survival ; Humans ; Reconstructive Surgical Procedures ; methods ; Surgical Flaps ; transplantation ; Time Factors ; Wound Healing

Objective To investigate the effects of carbon monoxide poisoning on the long-term cognition in elderly patients.Methods Totally 53 patients with carbon monoxide poisoning and 51 healthy persons at our Hospital from June 2005 to June 2008 were enrolled.Mini-mental state examination(MMSE) and activities of daily living(ADL) scale were utilized to evaluale the life quality of the elderly patients through a cross-sectional study on July 2011.Results MMSE score showed that the attention calculation score,delayed recall score,and total score were higher in control group (4.9±0.4,2.9±1.0,28.3±2.3,respectively) than in carbon monoxide poisoning group (4.5±0.8,2.6±0.6,25.5±3.5,respectively) (t＝3.138,3.607,4.802,all P＜0.05).ADL score of carbon monoxide poisoning group was 26.7±7.3,and that of the control group was 2.04±7.6 (t＝1.827,P＞0.05).Conclusions Elderly patients with acute carbon monoxide poisoning may cause long-term cognitive impairment with decreasing attention calculation and delayed recall.

To investigate the correlation between traditional Chinese medicine (TCM) syndrome and short-term prognosis of ischemic stroke.

BACKGROUND:For reducing the stress shielding, a lot of the schemes have adopted, and there is no great improvement although via the trial and the application for several ten years. It comes from a root which is the combination by thigh bone (abbreviation of the bone) and metal ic handle (abbreviation of the handle) which causes the serious problems of absorption of bone quality, and this kind of stress shielding effect is produced by abnormal stress and abnormal strain, and affected by various factors, so there is no effective and applicable method to solve this problem.
OBJECTIVE:To select the primary porous layer scheme as the subject of the study and entirely change the appearance and inherent quality as the metal ic handle that cannot transmit the stress is the key to eliminate the stress shielding;making the senior porous layer with the effective measure is the basis to eliminate stress shedding and can solve the disaster and partial inferior position aroused by the primary porous layer.
METHODS:The cobalt-chromium-molybdenum al oy smal metal ic spherules with equal diameter were used to manufacture the senior porous layer structure. The structural member employed in the thigh bone could separate the handle from the bone. This structural member welded on the plane of bone neck could fix the handle with calcar osteotomy surface. And these structural members had an ability to eliminate al the stress shieldings on the artificial hip joint surface.
RESULTS AND CONCLUSION:The senior porous layer was made with cobalt-chromium-molybdenum al oy smal metal ic spherules with the same diameter (1.00-1.29 mm), and the surface of the porous layer was plated with high property of medium layer al oy and arranged orderly and inseparable, and then connected with active diffusion welding technology. The diameter of al the holes was 155-200μm and distributed evenly which was benefit for the bone unit to grew. The al oying of metal materials, ceramic of al oy surface and control ing of size and number of wear particles can solve the bone dissolution of the surrounding porous layer of bone, metal dissolution as wel as its pure cobalt and chromium particle toxicity, cancerization and leukemia. A stipulation of theoretical basis was to eliminate the handle rigidity firstly that could made the separation of handle from the bone became the premise for eliminating the stress shielding. The calcar osteotomy surface grew into the pores of the structural member welded on plane of bone neck could fix the handle, and that was the basis for eliminating the stress shielding. The common roles can eliminate the stress shielding in thigh bone, and the stress shielding on acetabulum is easily to eliminate.

Objective To explore the main factors of hypokalemia in the patients with acute myocardial infarction after PCI.Method The clinical data of ninety-six patients with myocardial infarction after PCI were analyzed to look into the reasons for hypokalemia.Results Fifty-seven patients contracted hypokalemia,with a rate of 59.4%.The complication was cured by dietetic supplementation of potassium,oral supplementation of potassium,and potassium supplementation by atomization inhalation and intravenous infusion.The reasons for hypokelemia included inadequate input,over-ejectment,abnormal distribution of potassium and use of contrast agent.Conclusions Patients with myocardial infarction after PCI are more susceptible to hypokalemia.Therefore,it is a need to correct hypokelemia by means of potassium supplementation.

Recent studies have shown that pituitary hormones, including thyroid stimulating hormone (TSH), follicle stimulating hormone(FSH), adrenocorticotropic hormone(ACTH), and oxytocin(OT)may actually bypass their target endocrine organs and affect the skeleton directly. Therefore, a new conception, pituitary-bone axis is proposed. This breakthrough sheds a new light on the function of pituitary hormones and the pathogenesis of osteoporosis associated with hyperthyroidism, menopause or pregnancy, and even osteonecrosis after using glucocorticoids. In addition, it is conducive to give the reference guidance for clinical treatment of metabolic bone diseases and new drug development.