1.The feature, diagnosis, and treatment of fulminant type 1 diabetes
Chinese Journal of Endocrinology and Metabolism 2010;26(3):181-182
Type 1 diabetes includes two categories:autoimmune (type 1A) and idiopathic (type 1B)diabetes.Fulminant type 1 diabetes is a recently discovered subtype of type 1 diabetes with extremely rapid progression of hyperglycemia and ketoacidosis.The prevalence of fulminant type 1 diabetes among acute-onset type 1 diabetic patients is around 15%-20%.Class Ⅱ HLA genotype and virus infection may contribute to its development.The near-normal HbA_(1C) level despite a very high plasma glucose concentration in patients with ketoacidosis is the clue to diagnosis of fulminant type 1 diabetes.Treatment must be started immediately and aggressively when the diagnosis of fulminant type 1 diabetes is made or strongly suspected.
2.β cell dedifferentiation: new insight into the pathogenesis of β cell failure in type 2 diabetes——Gone backward already...and Coming back again?
Chinese Journal of Endocrinology and Metabolism 2012;(11):871-873
β cell failure is one of the important components in the pathogenesis of type 2 diabetes.Protecting and reversing β cell function is a critical part in diabetes treatments.It has been recently discovered that rather than apoptosis,β cell dedifferentiation into an endocrine progenitor-like stage is the main mechanism of β cell failure,which is closely related with the loss of FoxO1 on β cells.Some of these dedifferentiated β cells even have the potency to convert into α-cells.These great discoveries expand our understanding for the β cell exhaustion during the progression of hyperglycemia.It is worthwhile to reconsider our current treatment strategy for type 2 diabetes,especially during the beginning period,to protect rather than stimulate β cells.It also paves the way to develop a brand-new class of hypoglycemic agent to re-differentiate the already dedifferentiated β cells back into insulinsecreting cells.
3.Non-operative Treatment of Acute Traumatic Intracranial Hematoma
Academic Journal of Second Military Medical University 1985;0(06):-
Non-operative treatment in 105 cases of acute traumatic intracranial hematomas confirmed by CT scan is reported. Results were satisfactory except in 6 cases in which operation was performed because of the worsening of their conditions. In this paper, the indication, method, and advantages of non-operative treatment are also discussed. We believe that the change of state of consciousness, size of hematoma, degree of shift of midline structures and cerebral contusion, and type of hematoma are decisive factors in making the choice of operative or non-operative treatment.
4.New concept in the pathogenesis of diabetes: glucagonocentric model
Chinese Journal of Endocrinology and Metabolism 2013;(6):446-447
[Summary] The concept for the pathogenesis of diabetes is now changing from previousinsulinocentric model andinsulin/glucagon bihormonal model to a recentglucagonocentric model.Glucagon excess rather than insulin deficiency may play a more important role in mediating the glucose derangement during insulin insufficiency.Antagonizing glucagon signaling pathway may become a potential therapeutic modality in diabetes.
5.More basic and clinical studies on vitamin D/parathyroid hormone related disorders are needed
Chinese Journal of Endocrinology and Metabolism 2015;31(4):293-295
Vitamin D and parathyroid hormone (PTH) are two classical hormones modulating calcium and phosphorus homeostasis.The rapid development of modern endocrinology has greatly expanded our understanding of these two hormones.The extra-skeleton effects of vitamin D/PTH are well documented,novel findings regarding to the embryonic and adult parathyroid development,and the changing clinical patterns in certain parathyroid-related disorders have been discovered.
6.Clinical Analysis of Operation on 62 children with concealed penis
Chinese Journal of Primary Medicine and Pharmacy 2012;(8):1164-1165
ObjectiveTo sum up the diagnosis and differential diagnosis of concealed penis,analyze the indications and advantages of different operative methods for concealed penis.Methods62 children with concealed penis were treated by different surgical operations according to the different types,and the effect of surgical treatment was arelyzed.ResultsOpertaions were successed in all 62 cases,children were discharged after 5 ~ 10 operation days.After follow-up for 3 months to 2 years,62 children had received good recovered with an effective exposure of penis and no severe edema and other complications.ConclusionChildren with concealed penis should be given personalized scheme,choose the best method to extend the length of the penis and improve the penis appearance.
7.Genetic analysis of 1005 patients with vitiligo
Chinese Journal of Dermatology 2010;43(10):684-686
Objective To evaluate the role of genetic factors in the pathogenesis of vitiligo. Methods A questionnaire survey was performed to collect clinical data on 1005 cases of vitiligo in Beijing Hospital from September 1997 to March 2009. Data analysis was carried out by SPSS 13.0 software. Results There were 206 (20.5%) patients with positive family history among the 1005 cases of vitiligo. The mean age at onset was younger and bilateral vitiligo lesions were more frequently observed in patients with positive family history than those without (24.45 ± 15.87 years vs 28.12 ± 16.88 years, 71.3% vs 60.8%, both P < 0.05). Blood type B predominated among patients with positive family history (19.9%), while blood type O among those without ( 16.8% ), and no statistical difference was noted in the distribution of blood type between the two groups of patients (P > 0.05). Conclusions ①The incidence of vitiligo accords with the rules of polygenic inheritance and shows a familial aggregation, and the closer the blood relationship, the higher the incidence of vitiligo.②The incidence of vitiligo seems unrelated to sex. ③The mean age at onset is younger in patients with positive family history than those without, but appears unaffected by paternal or maternal inheritance. ④Patients with positive family history show a higher frequency of bilateral distribution of vitiligo lesions, but no difference in other clinical manifestions from patients without.
8.Effects of dried whey on the intestinal bacterial community and probiotics in weaned laboratory rabbits
Chinese Journal of Comparative Medicine 2015;(8):12-17
Objective To investigate the effects of dried whey on the intestinal bacterial community and probiotics in weaned laboratory rabbits .Methods A single factor design was employed to investigate the effects of dried whey supplemented at levels of 0%, 2%, 5%and 10%, respectively, on 48 weaned (40-day-old) laboratory rabbits.At the day 30, eight rabbits in each group were taken and sacrificed after anesthesia .The total bacterial DNA from the ceacal content of each selected rabbit was drew to analyze the bacterial community and intestinal probiotics ( Bifidobacterium and Lactobacillius) population by PCR-DGGE and real-time fluorescence quantitative PCR, respectively.Results 1) The DGGE parameters of ceacal bacterial community were increased with the increasing dried whey supplemental levels .The number of DGGE band in 2%, 5%and 10%dried whey supplement groups (P<0.05, P<0.01), the Shannon index in 5%and 10% supplement groups ( P<0.01 ) were significantly higher than that in the 0% supplement group , but the indices of DGGE band and Shannon index had no significant differences among the 2%, 5% and 10% dried whey supplement groups (P>0.05).Supplying dried whey has no significant effects on the homogeneity index (P>0.05).2) The population of Bifidobacterium and Lactobacillius in ceacal content had a trend of increase with the rising dried whey supplement levels .Compared with the 0% supplement group , the Lactobacillius population in the 2%, 5% and 10%supplement groups ( P <0.05 ) , the Bifidobacterium population in the 10% supplement group ( P <0.05 ) were significantly increased .Conclusions The results of our study indicate that: 1 ) Supplying dried whey in the feed of laboratory rabbit can effectively increase the diversity of ceacal bacterial community .2) Dried whey may effectively improve the intestinal probiotics population .
10.Present status of dilatative arteriopathy(Dolichoectasia)
Journal of Interventional Radiology 2006;0(08):-
Dilatative arteriopathy is also called Dolichoectasia, presenting as enlarged ,tortuous ,and dilated arteries; especially with involvement of intracranial arteries. The incidence of dolichoectasia is quite low, but it may induce recurrent strokes with poor prognosis and up to now there is no specific management. Our study reviews the potential etiology, epidemiology, symptoms, pathophysiology, prognosis and present status of treatment for dolichoectasia.