1.Establishment of Mathematic Model of the Extraction Kinetics of the Components of Chinese Complex Prescription and the Effect of Particle Size on the Concentration of Catalpol in Rehmanniae Decoction of Liuwei Dihuang Decoction
China Pharmacy 2007;0(36):-
OBJECTIVE:To establish a mathematical model for the dissolution kinetics of the components of the closed diffusion system of Chinese complex prescription,and to study and analyze the parameters of the extraction kinetics of catalpol,an active component in rehmanniae decoction of Liuwei dihuang decoction. METHDOS:The mathematic modeling method was applied to the extraction process of the traditional Chinese medicine; the mathematic model of the extraction process of the Chinese medicine was established based on the extraction principle and Fick law,and the function expression was derived from the fitting of the mathematic model and analysis of parameters,then the model was applied to the study of the kinetic parameters of the catalpol in rehmanniae decoction of Liuwei dihuang decoction. RESULTS:The analytic solution of the dissolution concentration of components consisting of 3 e in exponential form and the analytical method of parameters were obtained in this study. The optimal grain size of the herbal medicine was 60 meshes.Under this condition,the maximal peak time(tmax)of catalpol was 195.1 min;the peak concentration(Cmax) was 0.012 23 mg?mL-1;the maximal extraction rate(P) was 72.95%,and the loss rate(D) was 7.62%. CONCLUSION:The dissolution of the components of the closed soluble diffusion system of Chinese complex prescription fitted linear kinetic mathematical model,and the parameters can be derived from the expression relation of the dissolution concentration.
2.Comparison of the influence of different methods of perfusion on short-term prognosis in elderly patients with acute myocardial infarction
Chinese Journal of Primary Medicine and Pharmacy 2013;20(16):2408-2410
Objective To compare the effect of different perfusion methods on early outcomes of elderly patients with acute myocardial infarction.Methods The clinical data of 110 cases including EKG,echocardiogram and angiography were retrospectively analyzed.Of these patients,45 cases were treated by primary percutaneous coronary intervention (PCI),30 cases by intravenous thrombolysis,and 35 cases by PCI combined with intravenous thrombolysis therapy.The incidence rate of cardiovascular events during hospitalization,no reflow incidence,average hospitalized staying time,left heart function and Killip cardiac function grade at 3 months were compared between the three groups.Results There was no significant difference on incidence rate of cardiovascular events between the three groups (P > 0.05).Compared with PCI group and intravenous thrombolysis group,the combination group had lower no reflow incidence,less hospital time and lower Killip cardiac function grade (P < 0.05).In addition,the parameters of LVEF,CI and SVI of combination group were significantly higher than other groups after 3 months (P < 0.05).Conclusion PCI combined with intravenous thrombolysis was safe and effective in treatment of elderly STEMI patients,which could obviously decrease the no reflow rate,improve cardiac function and the early outcomes.
3.Study on Quality Standard for Ziyin Mingmu Tablets
Chinese Journal of Information on Traditional Chinese Medicine 2014;(1):88-90
Objective To establish the quality standard for Ziyin Mingmu tablets. Methods TLC method was used to identify Moutan Cortex, Corni Fructus, Notopterygii Rhizoma et Radix and Acori Tatarinowii Rhizoma. HPLC method was used to determine the content of Salvianolic acid B. Kromasil ODS column (250 mm×4.6 mm, 5μm) was adopted by using MeOH-acetonitrile-1.67%methanonic acid water solution (24∶10∶66) as the mobile phase. The detection wavelength was at 284 nm, column temperature was at 30℃, and the flow rate was 1.0 mL/min. Results The TLC spots were clear without interference of the negative control. The linear range of Salvianolic acid B was within 0.32-1.92 μg (r=0.999 9). The average recovery was 99.91% (RSD=0.63%). Conclusion The method is specific, reproducible and accurate, and can be used for the quality control of Ziyin Mingmu tablets.
4.Impact of different irrigation time on oxygenation index and acid-base balance during percutaneous neph-rolithotomy
Hongyu JIANG ; Bing LIU ; Jingchen LIU
The Journal of Clinical Anesthesiology 2014;(12):1187-1189
Objective To investigate the impact of different irrigation time on oxygenation in-dex and acid-base balance during percutaneous nephrolithotomy(PCNL).Methods Forty patients un-dergoing selective PCNL were included in this study,were divided into two groups:group S,irrigation time<120 min(n=22);group L,irrigation time≥120 min(n=18).PaO2/FiO2 ,pH and BE were determined before and after irrigation,CVP were recorded before irrigation and every 20 min during irrigation. Results The CVP maximum value were higher in group L than that in group S during irrigation (P <0.05).The PaO2/FiO2 were lower after irrigation than that before irrigation in group L(P<0.05).The pH and BE were lower in group L than that in group S after irrigation(P<0.05).Conclusion Irrigation fluid absorption is observed during PCNL.That can provoke oxygenation function decline and metabolic ac-idosis with irrigation time extend,the operation time properly shortened.
5.A randomized controlled study of water exchange colonoscopy and air insufflation colonoscopy
Xiaolin CHEN ; Jun LIU ; Hongyu REN
Chinese Journal of Digestive Endoscopy 2015;32(10):659-662
Objective To investigate the clinical application prospect of water exchange colonoscopy.Methods A total of 300 outpatients who underwent unsedated colonoscopy were randomized to the WEC group (n =150)or the AIC group(n =150).The maximum pain score, insertion time, the cecal intubation rate and the polyp detection rate were reported by an assistant during the insertion phase and at the end of colonoscopy.Results The maximum abdominal pain scores were 1.77 ± 1.29 in the WEC group and 2.84 ± 1.55 in the AIC group with significant difference (P =0.000).The intubation time of WEC was longer than that of AIC (11.91 ± 3.58 VS 8.03 ± 3.19 ,P =0.000)with no significant difference.There was no significant difference in the cecal access rate between the two groups(97.3% VS 94.0% ,P =0.157).The polyp detection of WEC was higher than that of AIC (16.7% VS 10.0%, P =0.089).In the post abdominal operation subject of colonoscopy procedure, WEC had higher rate of cecal intubation than AIC ,the maximum abdominal pain score were 2.25 ± 1.63 in the WEC group,lower than 3.48 ± 1.45 in the AIC group.Conclusion Water exchange colonoscopy can alleviate patients' abdominal pain symptoms, but with longer insertion time.There are no significant difference in the cecal access rate and the polyp detection rate between two groups.For difficult colonoscopy, water exchange colonoscopy is helpful to increase the rate of cecal intubation.
6.Study on the Stability of Yinzhihuang Injection Mixing With Five Kinds of Infusion Fluid
Rong OUYANG ; Hongyu LIU ; Xinbei ZHOU
China Pharmacy 2001;0(10):-
OBJECTIVE:To study the stability of Yinzhihuang injection(YZH) mixed with 5% glucose solution,10% glucose solution,glucose in normal saline,normal saline and Ringer's solution.METHODS:After YZH mixed with infusion fluid under room temperature,the contents of baicalin were determined with UV-spectrophotometry at different time periods within 24h,the apperance was observed,the pH values of baicalin were detected and identified by TLC.RESULTS:Under room temperature,after YZH mixed with Ringer's solution,the pH value of baicalin was markedly changed and a lot of white particles appeared;after YZH mixed with GNS,no changes of pH value and content of baicalin were found within 24h.When YZH mixed with other 3 kinds of infusion fluid,there were no changes in pH value and content of baicalin within 2h,however,in mixing with NS,the number of insoluble particles produced was beyond the standard.CONCLUSION:YZH should not be mixed with NS or Ringer's solution but it is compatible with 5%GS,10%GS and GNS,however,it should be mixed with them just before use and used up within 2h.
7.A study of genetic polymorphisms of 11 Y chromosome specific STR loci
Hongyu SUN ; Qiuling LIU ; Dayue TONG
Chinese Journal of Forensic Medicine 2002;0(05):-
Objective To study the genetic polymorphisms of 11 Y chromosome specific STR loci in Guangzhou Han population. Method The DNA extracted from blood samples of unrelated individuals in Han population living in Guangzhou were amplified by PCR. The PCR products were analyzed by using PAGE. Results 3-5 alleles were detected in 11 Y - STR loci respectively in Han population in Guangzhou. The minimum GD value was 0.3037 (DYS434), while the maximum GD value was 0.8455 (DYS390) . Conclusion The 11 Y - specific STR loci are highly polymorphic and are suitable for personal identification and paternity testing.
8.Survey on the supply of the fission 99Mo
Wei ZOU ; Hongyu YIN ; Qiong LIU
Chinese Journal of Nuclear Medicine and Molecular Imaging 2016;36(4):375-377
99Mo is the main raw material of 99Mo-99Tcm generator,its production stability directly determines the supply of 99Tcm.There exists very limited number of irradiation and processing facilities for fission 99Mo all over the world and most of them are aging.Different facets of problems are emerging,such as those related to supply chain withdrawal,reaction target changes,and maintenance shutdowns.This paper focuses on the discussion of the current supply status of fission 99Mo worldwide,its related problems and possible solutions offered by the corresponding agencies of different countries,operational parties,and the authors themselves.
9.The role of connexin in lung diseases
Chong LI ; Hongyu LIU ; Jianhua FU
International Journal of Pediatrics 2011;38(6):545-548
As a cell membrane protein of human body,connexins are closely related to the cell metabolism,proliferation and differentiation,which are highly expressed in lung.Recent studies have shown that connexins play an important role in the lung diseases,such as pulmonary fibrosis,lung injury,lung tumors and so on.This review is to summarize the characteristics of connexins molecules,biological function,the distribution in the lung tissues,as well as the possible regulation mechanisms in the lung diseases.
10.Eight Hundred and ninety-one cases with perimembranous ventricular septal defect performed minimally invasive transthoracic device closure
Hongyu LIU ; Weixin MENG ; Dan WU
Journal of Chinese Physician 2015;17(2):169-172
Objective To investigate retrospectively the therapeutic effect and safety of minimally invasive transthoracic device closure of isolated perimembranous ventricular septal defect (PVSD).Methods Eight hundred and ninety-one consecutive patients with PVSD from December 2008 to October 2014 in our hospital were enrolled,which performed minimally invasive transthoracic device closure of ventricular septal defect (VSD),with a 4 ~ 5 cm incision made on the inferior sternum.Under the guide of transthoracic echocardiography (TEE),right ventricular free wall was punctured followed by a delivery sheath threaded into the VSD and the occluder was released thereafter.Whether were there residual shunt and the occluder anchored firmly or not,the position of occluder and the influence on heart valve were re-evaluated intraoperatively by TEE.All patients were followed up prudently post-operation.Echocardiography and electrocardiogram were scheduled according to the protocol.Results Eight hundred and thirty-four cases were successfully occluded.Fifty-seven cases were performed VSD repair operation with cardiopulmonary bypass.The amounts of concentric occluder and eccentric occluder were 703 and 133,respectively.The patients performed minimally invasive transthoracic device closure of VSD had no severe complications after operation.Conclusions Although the short-term and mid-term therapeutic effect of minimally invasive transthoracic device closure of PVSD seem plausible to be definitive,with a favorable prospective application,the long-term follow-up remains to be studied.