Currently osteoporosis in children has become an important disease, which includes primary osteoporosis and secondary osteoporosis.Glucocorticoid induced osteoporosis is the most common secondary osteoporosis.Glucocorticoid has been widely used in clinical treatment of various inflammatory diseases and autoimmune function disorders, such as nephrotic syndrome and systemic lupus erythematosus.Although glucocorticoid has strong anti-inflammatory, anti-allergic and immunosuppressive effect,long-term use can cause a variety of complications, such as osteoporosis.This review focuses on the pathogenesis of glucocorticoid induced osteoporosis and its diagnosis and treatment strategy,in order to provide more extensive theoretical basis for pediatricians, to draw more attention for them, and also to provide appropriate evaluation and clinical guide.

Objective To analyze the clinical value of CDUS in the diagnosis of thyroid cancer.Methods 97 patients with TMC were diagnosed by CDUS and CT,the clinical value of CDUS was evaluated.Results A total of 1 1 2 lesions TMC,CT diagnosis of 81 ,CDUS confirmed 99,the positive rates were 72.32%,88.39% respectively.In 97 cases,1 3 cases of lymph node metastasis,CT diagnosis of lymph node metastasis rate was 53.85%,CDUS of 92.31 %.CDUS in diagnosis of TMC was effective than CT diagnosis (χ2 =4.887,P =0.027).Conclusion CDUS has important value in the diagnosis of TMC.

As a kind of new literature resource, Traditional Chinese Medicine (TCM) patent emerged in 1993 followed by a rapid development. Patent is a literature with academic, commercial, legal characteristics, carrying lots of the most timely and useful fruits of TCM research. The technological level of patent is not inferior to scientific papers, even better in terms of timeliness. By the end of 2013, the total number of patent applications for inventions related to traditional medicine had reached 204 000. For a long time, the study on TCM patents always focus on the tool of protection of intellectual property. While its role, as an information resources and a bridge binding scientific research and new drug development, has not been given adequate attention. This article briefly describes the job of the Key Lab of traditional medicine patent information resources and Beijing East Linden company, in medicine patent processing and utilization, and the idea of realizing the value of patent information resources, promoting innovation and development of Chinese medicine.

Patent is a type of technological literature with both academic and commercial value. Patents of traditional Chinese medicine (TCM) occurred by the establishment of Chinese medicine patent system, and got a rapid develop-ment by the TCM modernization. To date, TCM patents had been accumulated into a large and content-rich technol-ogy resource. Efficient utilization of TCM patents is of significant importance to government departments, research in-stitutions and pharmaceutical companies. However, due to the absence of patent awareness and knowledge, the TCM researchers have no idea on the use of TCM patent information resources. In this article, a brief review was present-ed on the development process of TCM patent. Besides, several issues of development were discussed in depth. We attempted to outline the guidelines and come out with a series of specific measures on exploring patent resources. The prospects of TCM patent resources were also analyzed.

Objective To investigate the prevalence,clinical traits and correlates of apathy in patients with Parkinson' s disease ( PD ).Methods Seventy-seven cases of PD patients and 40 health controls were recuited in the present study.Apathy was assessed using Lille Apathy Rating Scale(LARS) and related factors,such as motor function,cognition,depression,age,sex,education level,disease duration,levodopa equivalent doses (LED) and use of antipsychotic drugs were also evaluated.Four kinds of scales,Unified Parkinson' s Disease Rating Scale (UPDRS),Hoehn-Yahr staging,Montreal Cognitive Assessment (MoCA),Hamilton Depression Rating Scale (HAMD) were employed to evaluate the motor function,cogniton and depression,respectively.Results The prevalence of apathy and depression in the 77 PD patients were 49.4％ ( 38/77 ) and 46.8％ (36/77),respectively.Of the 77 PD patients,11 cases had apathy without depression (14.3％ ); 9 cases had depression without apathy( 11.7％ ) and 27 cases had apathy combined with depression( 35.1％ ).Among the PD patients with apathy,the cognitive type is the most common one,accounting for 86.8％ (33/38).There were significant statistical differences in education level,UPDRS- Ⅱ/Ⅲ scores,Hoehn-Yahr staging,MoCA and HAMD scores between apathy ( n =38 ) and no-apathy(n =39) PD patients(t =2.309,-3.144,-4.000,-3.217,2.649,-3.909,all P＜0.05).According to the unifactoral Logistic regression analysis of apathy correlates,UPDRS-Ⅱ/Ⅲ scores,HoehnYahr staging and HAMD scores were the risk factors for apathy while education level and MoCA were the protective factors for apathy.In the multiple Logistic regression analysis,HAMD scores,UPDRS-Ⅱ scores and education level were included.Conclusions The prevalence of apathy in PD patients was significantly higher than healthy controls.Apathy could be present without depression in PD patients,and was associated with education level,motor dysfunction degree,cognitive impairment and depression severity.

Traditional Chinese medicine (TCM) effect terminology is usually composed of a verb-noun structure such as clearing lung, expelling wind, killing worm and etc. The noun part, indicating objects of the ac-tion of TCM, is usually involved with some core concepts of TCM theory system. In this research, the 30 volumes of TCM work, which is Zhong Hua Ben Cao, were set as data source of the analysis. We collected TCM effect terms from 1702 TCM items. The most commonly used nouns were extracted, including 6 organ nouns, 11 concept nouns, and 9 illness nouns. Combined with modern pharmacological activity data for the 1702 TCM items, chi-square analysis and Spearman correlation analysis were employed to profile the modern pharmacological meanings of these noun terms.

The examining work of the third class medical metrology station in Xinjiang Military Area Command in 2006 is completely summarized along with the introduction of examining measures and experiences.Aiming at the problems in the examination,the importance of leader's recognition,propaganda and elaborate organization are emphasized.According to problems in the station's building,concrete methods for establishing corresponding mechanisms in coordination,learning,supervision and inspiring in medical metrology are discussed.

Objective: To assess the status of the interpersonal relationship of the current college students.Method: Approximately 456 students were tested with the interpersonal relationship of the current college students questionary.Result: In factor scores of associate attitude there existed the significant differences between south and north,low grade and high grade.In campus interpersonal atmosphere,the significant differences existed between students of poverty and students of impoverty.In the teacher and student relationship the significant differences existed between low grade and high grade,students of poverty and students of impoverty,singleton and insingleton.Conclusion: The interpersonal relationship of the college students is very important to students and the psychological education of interpersonal relationship should be conducted.

The paper describes the major steps taken by Hongze County of Jiangsu Province in reforming the health personnel system. These include: (1)adopting the personnel agent system; (2)implementing the all-personnel appointment system; (3)exploring ways of reforming the executive personnel management system; (4)setting up a flexible mobility system of health technicians; and (5)putting into effect the system of yearly salaries for Party and government principals. By reforming the personnel system, the awareness of crisis on the part of the entire staff was evidently enhanced, the quality of medical services was significantly improved, and the advancement mechanism of the health cause was rendered more flexible. As a result, the development of the health cause in rural areas was pushed to a new stage.

Objective The standard continuous terbinafine regimen (SCTR) is a classical treatment for onychomycosis but has many deficiencies .Therefore, researchers have tried several other therapeutic options .This study systematically evaluated the ef-fectiveness and safety of SCTR versus other therapeutic options in the treatment of onychomycosis . Methods We searched the PubMed, Cochrane Library, Embase, CNKI, CBMdisc and Wanfang databases for the randomized controlled trials on the treatment of onychomycosis with terbinafine .According to the study design , two authors independently selected the literature , extracted data , con-ducted data checking , and then performed meta-analysis. Results Totally, 20 randomized controlled trials were included .The pooled analysis showed that SCTR had a higher long-term mycological cure rate than pulse therapy ( P=0.01, RR=0.81 [0.69, 0.96]), COMBO (P=0.05, RR=0.68 [0.46, 1.01]), and intermittent strategy (P=0.0001, RR=0.81 [0.73, 0.90]). However, SCTR exhibited a lower long-term mycological cure rate than continuous +topical treatment ( P =0.005, RR =1.19 [1.05, 1.35]) and >3 mo continuous therapy (P=0.02, RR=1.12 [1.02, 1.24]).For moderate-to-severe mycological infec-tions, SCTR +aggressive debridement had potential advantages over SCTR alone .Compared with SCTR , continuous +topical treat-ment induced fewer gastrointestinal reactions (P=0.03, RR=0.24 [0.07, 0.90]), and intermittent therapy had lower incidences of adverse events (P=0.03, RR=0.81 [0.67, 0.98]) and taste disorders (P=0.05, RR=0.44 [0.19, 1.00]).Bias risk assess-ment based the tool a domain-based evaluationrecommended by the Cochrane Library found that some high-risk biases in the includ-ed studies might impair the credibility of the results . Conclusion The best terbinafine regimen for onychomycosis remains to be fur-ther investigated with more high-quality randomized controlled trials .