Objective To evaluate the clinical effects and safety when adopt smoothing liver and invigorating spleen treatment to cure diarrhea-predominant irritable bowel syndrome (D-IBS) characterized by liver stagnation with spleen deficiency.Methods 71 patients met the inclusion criteria of D-IBS were randomly divided into the treatment group(36 cases)and control group(35 cases),the treatment group used Shugan Jianpi therapy,traditional Chinese medicine Tongxieyao Fang and additive Shenlingbaishu Decoction; the control group taking Lactobacillus Complex Capsules treatment.Two groups of the time of taking medicine for 4 weeks.Observation and analysis of comprehensive effects and D-IBS symptom score before and after treatment.Results There was no statistical significance in the two groups before treatment,symptom total score difference,after the treatment group and the control group of symptom score were (4.83 ± 3.30),(7.00 ± 3.96),with a significant difference between the two groups (t =2.51,P ＜ 0.05) ; the total effective rate of treatment group was 91.67％,which was higher than 68.57 ％ in the control group(x2 =5.98,P ＜ 0.05).Conclusion The adoption of the smoothing liver and invigorating spleen treatment characterized by the use of Tong Xie Yao Fang and additive ShenLingBaiZhu decoction to cure D-IBS patients with liver stagnation and spleen deficiency has a relatively satisfactory clinical curative effect.

Papers on linked data published in foreign countries from 2005 to 2013 were analyzed, showing that the research of linked data in foreign countries is in its introduction period on the subject growth curve, the number of related literatures tends to increase, with a number of classical literatures and core researcher groups formed.At present, the research is focused on the theory, implementation and application of linked data.

After a description of the development of massive MOOC in domestic biomedicine and its characteris-tics, the major advantages and disadvantages of MOOC were analyzed in aspects of its copyright , guiding role of teachers, course experiments, and independent study of students, the application of MOOC in medical libraries was elaborated with 4 suggestions put forward for the development of MOOC in medical libraries.

Objective:To explore the relation of college students' life events,cognitive emotion regulation and life satisfaction.Methods:296 college students in Changchun completed the life events scale,emotion regulation questionnaire and life satisfaction scale.Results:①Academic pressure,inter-personal relationship and punishment were life events which influenced the most of student's life satisfaction;②Life events were positively correlated with cognitive emotion regulation(r=0.177,P

Using calmodulin dependent cyclic neucleotide phosphodiesterase and dansyl-labeled calmodulin,honokiol's action on calmodulin is studied. It is found that honokiol inhibits the activity of cyclic neucleotide phosphodiesterase induced by stimulus of calmodulin. With the increasing of calmodulin concentration, the IC50 value was increased. In the presence of Ca2+, honokiol reduces the fluorescence intensity of dansyl-calmodulin, and makes the spectrumpeaked red. The results indicate that honokiol can combine with calmodulin in the presence of Ca2+ and antagonise the effect caused by calmodulin's stimulation upon the phosphodiesterase. In addition , honokiol may exert its effect on the basal activity of calmodulin dependent cyclic neucleotide phosphodiesterase.

The distribution features of studies on reading popularization in CNKI-covered CSSCI papers were demonstrated from the aspects of their annual distribution, core authors and institution co-occurrence network by bibliometric, visualization and contents analysis.The study hot spots in the two development periods of reading popularization were displayed in the form of knowledge map with the study contents assessed in brief in order provide certain reference for the creative development of reading popularization theories and practice.

AIM:To study the method of determing camphor, menthol, synthetic bornel and the wintergreen oil contents in Shexiang Zhunggu Plaster. METHODS: Gas phase chromatogram was used to determine contents of camphor, menthol, synthetic bornel and the wintergreen oil in Shexiang Zhuanggu Plaster. The chromatogram condition consisted of the capillary vessel column(PEG-20M, 30 m?0.32 mm?0.25 ?m). The temperature programing rose from 100 ?C to 130 ?C by 5 ?C /minute, then 30 ?C /minute to 200 ?C , lasting 2 minutes in the end. The temperature of the entrance of the capillary vessel column: at 220 ?C , temperature of the detector was 240 ?C ; N_2: 5 mL/minute, H_2: 45 mL/minute, Air: 450 mL/minute; sample quantity was 0.2 ?L. RESULTS: Under certain chromatogram condition, there was linear relation among the camphor, menthol, synthetic bornel and the wintergreen oil and the peak area in the scope of 0.027 38 mg/mL-0.438 08 mg/mL, 0.041 15 mg/mL-0.658 4 mg/mL, 0.033 38 mg/mL-0.534 1 mg/mL, 0.042 15 mg/mL-0.674 4 mg/mL, respectively. The average recoveries were 98.37%, 99.76%, 98.80% and 97.61%, respectively. RSD were 1.7%, 1.8%, 0.96% and 1.5%, respectively. CONCLUSION: This experiment provides an accurate and reliable method to control the quality of Shexiang Zhuanggu Plaster.

Several minimally invasive techniques were used to treat infection secondary to pancreatic and (or peri-pancreatic) necrosis recent years,including percutaneous catheter drainage (PCD),endoscopic transluminal treatment,min-incision surgery,video-assisted minimally invasive technique and laparoscopic surgery.We should grasp the indication of each technique.PCD/ endoscopic transluminal surgery usually acted as initial therapy.Open surgery is still effective,and acts as a rescue operation when minimally invasive techniques fail.

Forensic dentistry is an interdiscipline of forensic m edicine and stom atology, w hich provides legal inform ation by collecting, testing and assessing the dental evidence scientifically. In this review , the present application of forensic dentistry has been described, such as the estim ation of age, sex, species, occupation and living habit, as w ell as the identification of individual, dom estic violence or abuse, w hich aim s to enrich and im prove forensic dentistry for m aking it be m ore useful in forensic m edicine even in juridical practice.

Pharmacogenomics does not only bring the connection of genes,medicines and diseases,but also become a powerful tool for clinical pharmacists.Pharmacogenomics is commonly used in clinical practice,especially in the implementation of genetic-test results for guiding rational use of medicines.The genotyping results of genes can provide good individualized medication guidance for patients,which can be confirmed by clinical use of the clopidogrel and warfarin.As a member of the clinical treatment team,clinical pharmacists should take advantage of pharmaceutical and pharmacogenomics information to promote rational use of medicines.