Objective To evaluate the clinical effects and safety when adopt smoothing liver and invigorating spleen treatment to cure diarrhea-predominant irritable bowel syndrome (D-IBS) characterized by liver stagnation with spleen deficiency.Methods 71 patients met the inclusion criteria of D-IBS were randomly divided into the treatment group(36 cases)and control group(35 cases),the treatment group used Shugan Jianpi therapy,traditional Chinese medicine Tongxieyao Fang and additive Shenlingbaishu Decoction; the control group taking Lactobacillus Complex Capsules treatment.Two groups of the time of taking medicine for 4 weeks.Observation and analysis of comprehensive effects and D-IBS symptom score before and after treatment.Results There was no statistical significance in the two groups before treatment,symptom total score difference,after the treatment group and the control group of symptom score were (4.83 ± 3.30),(7.00 ± 3.96),with a significant difference between the two groups (t =2.51,P ＜ 0.05) ; the total effective rate of treatment group was 91.67％,which was higher than 68.57 ％ in the control group(x2 =5.98,P ＜ 0.05).Conclusion The adoption of the smoothing liver and invigorating spleen treatment characterized by the use of Tong Xie Yao Fang and additive ShenLingBaiZhu decoction to cure D-IBS patients with liver stagnation and spleen deficiency has a relatively satisfactory clinical curative effect.

Papers on linked data published in foreign countries from 2005 to 2013 were analyzed, showing that the research of linked data in foreign countries is in its introduction period on the subject growth curve, the number of related literatures tends to increase, with a number of classical literatures and core researcher groups formed.At present, the research is focused on the theory, implementation and application of linked data.

After a description of the development of massive MOOC in domestic biomedicine and its characteris-tics, the major advantages and disadvantages of MOOC were analyzed in aspects of its copyright , guiding role of teachers, course experiments, and independent study of students, the application of MOOC in medical libraries was elaborated with 4 suggestions put forward for the development of MOOC in medical libraries.

Integrative medicine is the effective combination of dual diagnosis of Chinese medicine and western medicine.The combination can broaden the scope of clinical diagnosis and combine the local pathological changes with the overall response of the human disease.It can add a more comprehensive understanding of diseases for people.Clinically treated with combination of Chinese medicine and western medicine can achieve the complement of advantages.It is significant.Because the theory system of Chinese medicine compared with western medicine is different and the theory system of combination is not practical and standardized.The methods of clinical diagnosis and treatment are also different.So there are still some problems and deficiencies in the integrative medicine.In this study,through extensive literature research,as well as the clinical investigation in some integrative medicine hospitals and the collection of related clinical data,we compared and analyzed the academic ideas and different features of Chinese medicine and western medicine,analysed the status and the insufficience of current clinical integrative medicine.Finally,we put forward a series of effective strategies and methods for how to combine with integrative medicine in a specific,reasonable and effective way.

The factors influencing the integration of MOOC and information literacy education in academic libraries were divided into objective factor, subjective factor and social factor according to their connotation and significance. Certain measures for their integration were proposed, such as strengthening network construction, perfecting literacy education systems, and carrying out systemic training.Integration of MOOC and information literacy education in academic libraries can improve information service, promote wide application of MOOC and information literacy ed-ucation in academic libraries.

The glucose metabolism pathways including glycolysis and oxidative phosphorylation in vivo.The metabolism of tumor cells depends on glycolysis,which enhances the adaptability of tumor cells to the microenvironment and promotes the proliferation of tumor cells,which is called Warburg effect.Arsenic is one of the chemical pollutants,which is widely distributed in natural environment.International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens.However,the mechanism of carcinogenesis induced by arsenic still remains obscure.Recently,researchers have found that Warburg effect plays an important role in the process of arsenic carcinogenesis.In this paper,we have reviewed the definition and function of glycolysis,its relationship with inflammation and tumorigenesis,and the role of Warburg effect in arsenic carcinogenesis.

Objective To evaluate the effect of retroperitoneal laparoscopic ureterolithotomy (RLUL),ureteroscopy(URS),microchannel percutaneous nephrolithotomy (mPCNL) in the treatment of impacted upper ureteral calculi.Methods Clinical data of 105 cases with impacted upper ureteral calculi were retrospectively analyzed.The average residence time of stone in the same position was 8.6 (2-49) months and the average stone surface area were 171 (71-361)mm2 in 41 cases received RLUL treatment.The average residence time of stone in the same position was 9.5 (2-47) months and the average stone surface area were 159 (71-342)mm2 in 29 cases received URS treatment.The average residence time of stone in the same position was 8.9 (2-51) months and the average stone surface area were 165(71-353)mm2 in 35 cases received mPCNL treatment.Results In the RLUL group,surgery was successful in all patients and the stone-free rate was 100％ ;In the URS group,the surgery success rate was 93.1％ and the stone-free rate 1 month later was 92.6％ ;In the mPCNL group,the surgery success rate was 97.1％ and the stone-free rate 1 month later was 97.0％.The operation time in the URS group (mean 65 min,ranged 45-95 min)was longer than that in the RLUL(mean 46 min,ranged 25-70 min) and mPCNL(mean 51 min,ranged 39-80 min)groups (P＜0.05).The hospital stay in the URS group (mean 5.1 days,ranged 4-12 days) was shorter than that in the RLUL(mean 7.9 days,ranged 6-11 days) and mPCNL(mean 8.1 days,ranged 5-18 days)groups (P ＜ 0.05).The operation time and the hospital stay had no significant differences between the RLUL group and mPCNL group (P ＞ 0.05).The surgery success rate,stone-free rate and the serious complications of the three groups had no significant differences (P ＞ 0.05).Conclusion The operation time of URS is shorter,but postoperative recovery is faster than that of RLUL and mPCNL groups.Although the incidence of serious complications has no statistically significant differences among the three treatments,but URS and mPCNL surgery have the potential risk of serious complications.RLUL does not increase the difficulty of operation,has less serious complications,and is a remedy for failure in URS and mPCNL operation.

The distribution features of studies on reading popularization in CNKI-covered CSSCI papers were demonstrated from the aspects of their annual distribution, core authors and institution co-occurrence network by bibliometric, visualization and contents analysis.The study hot spots in the two development periods of reading popularization were displayed in the form of knowledge map with the study contents assessed in brief in order provide certain reference for the creative development of reading popularization theories and practice.

Biology-related disciplines in medical school of comprehensive university are cur-rently confronted with some difficulties, including unclear position and indistinguishable characteris-tics. In this paper, we proposed that biology-related disciplines in medical school of comprehensive university should center on disease research, emphasize medical feature and give full play to its tech-nical advantage thus to provide technical support for basic medicine and clinical medicine. Mean-while, sources of multiple disciplines should be effectively integrated by breaking through the limitation of discipline and administrative system. An interdisciplinary molecular medicine platform was built up for researching and teaching.

Abstract: In order to improve the quality of reporting Chinese herbal medicine (CHM) trials, an elaborated checklist was developed according to the basic characteristics of traditional Chinese medicine (TCM) and on the basis of the Reporting Randomized Controlled Trials of Herbal Interventions: An Elaborated CONSORT Statement. This checklist adopted the 22 items of the Herbal CONSORT Statement with some necessary elaboration and modification in the detailed contents of 11 items, among which, the items of Participants, Intervention, Control group and Outcomes were elaborated and modified accordingly to adapt TCM characteristics. Since the design and reporting of trials on Chinese proprietary medicine and herbal decoctions are different in some aspects, the checklist provided two sets of elaborated item 4 (interventions). We hope that authors, journal editors and peer reviewers find this checklist instructive.