Through the analysis of evaluation indexes, efficiency analysis of a hospital introducting large medical equipment beyond millions yuan in recent 3 years,suggestions of hospital equipment management are proposed.

Juvenile polyps are the most common colorectal polyps in children,usually present with painless,intermittent rectal bleeding.Colonoscopy is used to diagnose and juvenile polyps should be removed once found.The etiology and pathogenesis of juvenile polyps is still unclear.Histologically,the typical juvenile polyp is hamartoma with a prominent lamina propria,infiltration with inflammatory cells and cystic glands.This article reviewed the recent progress in the study of the clinical manifestation,histological characteristics,biological characteristics,diagnosis,treatment,pathogeny and molecular mechanisms of colorectal juvenile polyps in children.

Objective To implore FHIT expression in the tissue of cervical carcinoma and its clinical significance. Methods To determine the FHIT expression in 42 cases of cervical carcinoma by S2P immunohistochemical staining and to make a comparison with the normal one. Results The FHIT expression in normal tissue showed to be normal or even positive. No descending or short one occurred. The expression in cervical carcinoma was significantly low or short, abnormal one reached 57.14 %. The descending and short expression had something to do with histological type and grade (P 0.05). Conclusions The ascending or descending of FHIT expression plays an important role, which might influence the prognosis of cervical carcinoma.

Objective To study the relationship between B-type natriuretic peptide(BNP) and type 2 diabetes mellitus(DM) patients with congestive heart failure(CHF).Methods 78 patients with DM were divided into pure DM group(n=37) and DM+CHF group(n=41) ,the level of plasma BNP in patients with DM(n=78) and normal control group(n=20) was.measured.Results The level of plasma BNP in grade Ⅱ ,Ⅲ～Ⅳgroup of cardiac function were significantly higher than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly higher than that in grade II group(P<0.05),LVEF in Ⅱ,Ⅲ～Ⅳgroup of cardiac function were significantly lower than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly lower than that in grade Ⅱ group(P<0.05) ;The level of plasma BNP was positively related to LVEF(r= -0.713,P<0.05).Conclusion BNP was an objective indicator to evaluate the severity of DM with heart failure.

Objective To study the effects of trimetazidine on cardiac function in type 2 diabetes mellitus patients with heart failure. Methods Ninty type 2 diabetes mellitus patients with heart failure were randomly divided into two groups (45 patients in control group,45 patients in treatment group). All patients in both two groups received routine therapy in order to have blood glucose under control,the treatment group was treated with trimetazidine 20mg po Tid ,treatment for 6 months. Before and after treatment ,two groups were detected left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF), and the clinical efficacy were evaluated. Results Ater treatment, the rate of total efficiency was 68. 9% in control group, and it was 86. 7% in treatment group. The clinical efficacy of treatment group was significantly better than control group(P＜0.05) ;Ater treatment,LVEDD,LVESD were significantly reduced than those before treatment(P ＜0.05) ,LVEF was significantly higher than that before treatment (P ＜0.05);After treatment,LVEDD, LVESD in treatment group was significantly reduced than those in control group, LVEF was significantly higher than control group (P ＜ 0.05).Conclusion Trimetazidine can significantly improve the cardiac function in type 2 diabetes mellitus patients with heart failure.

Impulse oscillometry system(IOS) is a new pulmonary function test in recent years, IOS has been developed as a patient-friendly lung function test that minimizes demands on the patient, a noninvasive method without pain, the results is objective and comprehensive, suitable for all patients, especially for the elder ly, children, coma patients, pregnant women and critically ill patients, for better detection, diagnosis, and treat ment of different respiratory diseases.This article is to determine the reference values of IOS, its utility in children, the existing questions and its development prospect.

The highly down-loaded 175 papers from 7 journals of ophthalmology covered in Scopus database in 2011 were analyzed,showing that the most concerned subjects were rintinopathy,macular edema,glaucoma, neovasculariza-tion,Ranibizumab, retinal blood vessel obstruction, OCT,cornea, artificial lens, diabetic retinopathy, nanometer medicine and technology,the research has extended to retro-ocular segment from anterior-ocular segment,the papers of multiple authors accounted for 92%, the reviews accounted for 51.42%and were highly down-loaded.

The source indexes for the coverage of Chinese biomedical journals in MEDLINE were analyzed and compared with the mean values of those for the journals in each subject,which showed that the number of MEDLINE-covered papers published in Chinese medical journals was small ( about 260 papers each year) , the number of au-thors in each paper was 5 and the number of references in each paper was 17 with a half-life of 6. 175 years. The MEDLINE-covered Chinese medical journals did not emphasize on the publication of papers from overseas. However, it seemed that they could attract more found-supported papers.

BACKGROUND: Myasthenia gravis is a spectrum of disease that there are varied options of treatment. A consensus guideline is conceived by the Neuromuscular Council of the Philippine Neurological Association to summarize all the possible options of treatment in generalized autoimmune myasthenia gravis.
METHODS: Articles were retrieved from 1966 to 2012 from the internet, appraised, summarized, and consolidated to come up with recommendations in this treatment guideline. The American Academy of Neurology classification of evidence (Class I,II,III,IV) and levels of recommendations (Level A, B, C. U) were used.
RESULTS: New insights were found on the pathophysiology of autoimmune myasthenia gravis; reviews and outcome of treatment groups as well as the newest immunosuppressant which is rituximab as added to the armamentarium of medical immunosuppression. There are only a few small population randomized controlled trials on some immunosuppressant drugs like cyclosporine, tacrolimus and mycophenolate. Most studies are retrospective or open labelled studies. Thus, most recommendation grade is at Level C.
CONCLUSION: This guideline summarizes the following: Pyridostigmine is the initial treatment for the mild stage or beginning of myasthenia symptoms. For rapid progressive illness, the option of thymectomy is introduced followed by prednisone followed by azathioprine . For poor responders, the following are additional options: cyclosphosphamide, cyclosporine, mycophenolate, tacrolimus, methotrexate and rituximab. Management of MG crisis is mechanical ventilation, plasma exchangeor IVIg with prednisone and/or azathioprine. IV cyclophosphamide may be given for resistant severe crisis of MG patients.

Human ; Azathioprine ; Tacrolimus ; Thymectomy ; Prednisone ; Cyclosporine ; Pyridostigmine Bromide ; Rituximab ; Methotrexate ; Immunoglobulins, Intravenous ; Respiration, Artificial ; Immunosuppressive Agents ; Myasthenia Gravis ; Cyclophosphamide ; Neurology

Objective To observe the effect of two kinds of antibiotic therapeutic combined with humanistic care for neonates with infectious pneumonia and for intestinal micro ecology.Methods 210 neonates with infectious pneumonia and without complications from March 2011 to July 2013 were randomly divided into the cephalosporins group(n =50),the penicillins group(n =48)and the combination group(n =52),60 healthy neonates were selected as control.The cure rate,cure time in these groups were compared and the intestinal micro flora were calculated after 5 days with antibiotic treatment to evaluate the antibiotic effect to neonatal intestinal micro ecology.Results There was no significant difference between the cure rate of the cephalosporins group (76.00%),penicillins group (70.83%)and combination group(71.15%)(χ2 =2.517,P >0.05).The bifidobacteria quantity in the drug groups was significantly lower than that in the control group(t =4.600,3.634,4.275,all P <0.01),while the quantity of enteric bacilli(t =4.600,3.634,4.275,all P <0.01),enterococci(t =5.295,4.873,5.041,all P <0.01)and pep-tostreptococcus (t =3.056,2.900,3.113,all P <0.01 )in the drug groups were higher than those in the control group,but the quantity of bacteroidosis had no significant difference among the three groups (t =0.112,1.096, 1.943,all P >0.05).Conclusion Cephalosporin antibiotics and combination is not superior to penicillin,but in-clined to combined medication;antibiotics will destroy the neonatal intestinal micro ecological imbalance,endanger the health of newborn.