Objective To investigate the impacts of Xuebijing injection on systemic inflammatory response and immune function of patients with acute exacerbation of severe chronic obstructive pulmonary disease (AECOPD). Methods A prospective randomized controlled trial (RCT) was conducted. Forty patients with severe AECOPD were divided into control group and Xuebijing group in accordance with the random number table, each group 20 cases. Both groups were treated by routine conventional basic therapy of severe AECOPD including anti-infection, phlegm-expelling formula, bronchodilators and mechanical ventilation, etc, while in Xuebijing group, intravenous drip of Xuebijing (100 mg, twice a day for 5 days) was additionally used. The changes of data of arterial blood gas analysis, blood routine examination, C-reactive protein (CRP), procalcitonin (PCT), immune function, and acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ) score before and after therapy were observed and compared between the two groups. The length of stay in hospital, duration of mechanical ventilation, and prognosis were also compared between the two groups. Besides, according to the difference in APACHE Ⅱ score, all the patients were divided into APACHEⅡscore≥15 score group (18 cases) and APACHEⅡscore<15 score group (22 cases), and the immune function were compared between the two groups. Results ①The immune function was descended and disordered in patients with severe AECOPD. Compared with the < 15 score group, the expressions of CD45+, CD3+, CD4+, CD4+/CD8+ ratio, B-lymphocyte, natural killer cell (NK cell) in ≥ 15 score group were significantly lowered [CD45+(×106/L):663.92±100.61 vs. 1 289.92±169.38, CD3+(×106/L):342.05±108.93 vs. 882.37±172.56, CD4+(×106/L):205.96±63.97 vs. 486.24±108.64, CD4+/CD8+ratio:0.76±0.49 vs. 1.32±0.57, B-lymphocyte (×106/L):124.77±32.72 vs. 166.06±48.02, NK cells (×106/L): 186.47±39.57 vs. 243.51±44.72, all P < 0.05]. There was no statistically significant difference in the expression of CD8+ between the ≥ 15 score group and < 15 score group (P > 0.05). ② Compared with those before therapy, the pH value, oxygenation index, arterial partial pressure of carbon dioxide (PaCO2), white blood cell count (WBC), CRP, PCT were significantly improved after therapy in both control and Xuebijing groups. Compared with those in the control group, WBC, CRP, PCT were significantly lowered in Xuebijing group [WBC (×109/L): 10.29±3.83 vs. 12.69±3.42, CRP (mg/L): 9.06±4.19 vs. 15.26±4.22, PCT (ng/L): 0.18±0.21 vs. 0.42±0.24, all P < 0.05]. There were no statistically significant differences in pH value, oxygenation index and PaCO2 between two groups (all P>0.05). The degrees of improvement of CD45+, CD3+, CD4+, CD8+ and CD4+/CD8+ ratio were more remarkable in Xuebijing group after treatment than those in control group [CD45+ (×106/L): 1 079.38±153.86 vs. 1 015.63±157.11, CD3+ (×106/L): 652.05±100.05 vs. 596.81±106.85, CD4+ (×106/L): 358.92±67.53 vs. 329.99±72.61, CD8+ (×106/L): 205.73±35.19 vs. 230.41±39.74, CD4+/CD8+ratio: 2.16±0.63 vs. 1.52±0.54, all P < 0.05]. The B-lymphocyte and NK cell before treatment and after treatment showed no statistical significant differences between the two groups (all P > 0.05). Compared with the control group, the duration of mechanical ventilation (hours: 56.25±22.87 vs. 69.45±26.59) and the length of stay in hospital (days: 11.00±0.74 vs. 14.00±2.06) were shortened, and APACHE Ⅱ score was significantly lowered in Xuebijing group (8.21±2.97 vs. 12.08±3.12, P < 0.05). The numbers of multiple organ failure and dead patients in Xuebijing group were less than those of control group, but no statistical significant differences were found (both P > 0.05). Conclusion Xuebijing injection for treatment of patients with severe AECOPD can ameliorate inflammatory response, improve immune function, shorten the duration of mechanical ventilation and the length of stay in hospital, and decrease the risk of death.

Objective To understand the clinical distribution and drug resistance situation of112 strains of Acinetobacter Bau-mannii isolated from the patients′sputum samples in cerebral surgery ICU in order to provide the basis for the rational use of anti-bacterial drugs in clinical therapy.Methods 112 strains of Acinetobacter Baumannii were performed the retrospective analysis.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and the drug susceptibility test and the K-B method was combined as the supplement control.The Whonet 5.6 software was used for conducting the statistical analysis.Results Among 112 strains of Acinetobacter baumannii,75 strains(67.0%)were multi-drug resistant,8 strains(7.1%) were pan-resistant.The antimicrobial susceptibility tests showed that the resistant rates of Acinetobacter baumannii to mezlocillin, piperacillin and nitrofurantoin reached up to 100%.Acinetobacter Baumannii had the lower resistant rate to polymyxin B (2.7%), the resistant rates to minomycin and ceperazone/sulbactam were 4.5% and 10.7% respectively.Conclusion The drug resistance phenomena of Acinetobacter Baumannii in the cerebral surgery department ICU is serious.Minomycin,polymyxin B and ceperazone/sulbactam have the better antibacterial activities to clinically isolated Acinetobacter Baumannii and may be the alternative drugs for therapy.Clinic should strengthen the monitoring and rationally use the antibacterial drugs.

Cardiac Catheterization ; trends ; Forecasting ; Heart Defects, Congenital ; therapy ; Humans

Arrhythmias, Cardiac ; therapy ; Biomedical Research ; methods ; standards ; Catheter Ablation ; Child ; China ; Drug Therapy ; Humans

Culture ; Medicine, Chinese Traditional ; Research ; Translations

Adult ; Burns ; etiology ; Humans ; Male ; Occupational Exposure ; Phosphorus ; adverse effects ; Young Adult

Objective To observe effect of baicalin on VEGF, BMP-2 and IL-1βexpression in rat mobile dental periodontitis maintained phase, and explore the mechanism of baicalin on periodontal tissue remodeling.Methods 80 SD rats were randomly divided into four groups,20 rats in each group.The blank group weren’t giren any treatment, model group were built with periodontitis, control group and observation group were built with periodontitis and then tooth movement model.The observation group were given baicalin, blank group and control group were given the same volume of saline.The rats were killed at 1d, 3d, 6d, 12d, 18d, then samples of the maxilla were taken to make tissue sections and immunohistochemical staining. VEGF, BMP-2 and IL-1βexpression were observed in periodontal tissue.Results The BMP-2 expression isn’t obvious in blank group, but was obvious in model group, and gradually reduced at the end of the afterburner; BMP-2 expression in experimental group were higher than that in control group at the same point ( P<0.05 ) .The VEGF expression in control group and experimental group gradually reduced at the end of the afterburner; VEGF expression in experimental group were lower than that in control group at the same point ( P<0.05 ) .The IL-1βexpression wasn’t obvious in blank group, but was obvious in model group.The IL-1βexpression in control group and experimental group gradually reduced at the end of the afterburner;IL-1βexpression in experimental group were lower than that in control group at the same point ( P<0.05 ) .Conclusion Baicalin can significantly increase the expression of IL-1βin periodontal tissues of periodontitis rats after moving teeth, reduce inflammation, inhibit bone resorption, and also increase BMP-2 and VEGF expression, promote periodontal vessel formation and maturation, which may be one of the mechanisms of baicalin to promote periodontal tissue remodeling in periodontitis rats at holding phase after orthodontic tooth movement.

Objective To examine the moderating effects of cognitive emotion regulation strategies on neuroticism and depression in college students.Methods Correlation and Hierarchical Regression Analysis were used to analyze the surveyed data collected from 824 college students.Results Among all the cognitive emotion regulation strategies,college students used the rational analysis most frequently (14.1 ± 2.57) and used the catastrophizing least frequently(7.74±2.76).After controlling the effects of depressive symptoms at T1,the standard regression coefficients of neuroticism to depression were significant (β=0.137,P＜0.001).The standard regression coefficients of positive refocusing to depression (β=-0.073,P＜0.05) and the standard regression coefficients of rumination and catastrophizing to depression were all significant(β=0.137,P＜0.001 ; β=0.143,P＜0.01).The interaction between neuroticism and catastrophizing were significant (β=0.0535,P＜0.05),whereas the interaction between neuroticism and blaming others were significant(β=-0.620,P＜0.01).Conclusion Catastrophizing positively moderates the effects of neuroticism on depression,while blaming others negatively moderates the effects of neuroticism on depression.

Objective To investigate the clinical efficacy and safety of electroacupuncture plus pelvic floor muscle training in treating postoperative retention of urine. Method Patients were allocated, according to admission date, to a treatment group of 33 cases and a control group of 34 cases. The treatment group received electroacupuncture at point Ciliao (BL32) plus pelvic floor muscle training and the control group, intermittent catheterization. The overall health degree was assessed using the therapeutic effect evaluation, first voiding time, residual urine volume and the number of urinary tract infection patients before and after treatment. Result The improvement rate was higher in the treatment group than in the control group and there was a statistically significant difference (P<0.05). Voiding recovery time was shorter and residual urine volume was smaller in the treatment group and there were statistically significant differences compared with the control group (P<0.01). Conclusion Electroacupuncture plus pelvic floor muscle training can effectively treat postoperative retention of urine. It is a safe and effective therapeutic method.

Objective To explore the relationship between primary hepatic cancer (PHC) and hepatitis B virus(HBV),hepatitis C virus(HCV),and discuss the relationship between PHC and HBV,HCV overlapping infection.Methods To examine hepatitis B virus markers (HBV-M) and anti-HCV in 206 cases PHC.Results In 206 cases,patients with HBV infection correlation is 93.20％.Most of cases (43.20％) showed the HBsAg,anti-HBe and anti-HBc positive,followed by HBsAg and anti-HBc positive (19.90％),and few of cases showed the other expression patterns in PHC HBV-M pattern.In 206 cases,patients with HCV infection correlation is 18.45％,overlapping infection patients are 24 cases (11.65％).Conclusion PHC are closely associated with HBV,HCV infection that are the important factors in the development of PHC occurrence.We should regular examine the patients who infect HBV and HCV,between 40 and 60 years old,especially with cirrhosis,we stive to make the PHC early detection,early treatment,in order to improve the survival rate of PHC.