Objective To investigate the role of Ginsenosides Rg1 for non-alcoholic fatty liver disease by β-oxidation.Methods 120 SD rats were randomly divided into control group(CON),model group(HFD),Ginsenosides Rg1low,medium and high dose group (GLD ,GMD and GHD) ,sodium deoxycholate of bear treatment group (PDT ) ,20 rats in each group .After 4 and 8 weeks treatment ,the rats were sacrificed ,Pathology of hepatic tissue was tested by HE staining ,and liver function ,lipid levels ,hepatic ac-yl-CoA synthetase (CoASH1) ,carnitine acyl transferase I(CATI) and acetyl coenzyme A oxidase 1 (ACOX1) mRNA and protein expression were tested .Results After 4 weeks of treatment ,the liver function tested by HE staining only improved in GHD group . After 8 weeks ,there′s a little fat particles aggregation in PDT and GLD groups ,but no infiltration of fat in GMD and GHD groups . After 4 weeks ,AST ,ALT and AKP ,CHOL ,TG and LDL-C levels were significantly lower in PDT ,GLD ,GMD and GHD groups compared with HFD group (P<0 .05) ,which were significant declined 8 weeks later .After 4 weeks ,HDL-C level in four groups was significantly increased ,then reached the normal level 8 weeks later .After 4 weeks ,CoASH1 ,CATI and ACOX1 expressions in hepatic tissue of four groups were significantly increased ,which improved more obviously after eight weeks .Conclusion Ginsen-oside Rg1 can improves nonalcoholic fatty liver phenotype by regulation of β-oxidation .

Objective To explore the interventional effect of two different methods in the prevention of chemotherapy phlebitis caused by 5-fluorouracil.Methods Eighty cases of patients treated with cisplatin+5-fluorouracil (PF) chemotherapy in the First Affiliated Hospital of Guangxi Medical University from May 2015 to July 2016 were selected and divided into the observation group and control group according to admission time,40 cases in each group.The observation group was smeared with 2% anisodamine along the direction of vein puncture after peripheral venous puncture success,while the control group was smeared with mucopolysaccharide polysulphate emulsion paste.The occurrence of phlebitis and degree of local pain after intervention were compared between the two groups.The blood biochemical indexes and inflammatory factors levels before and after intervention were compared too.Results After the intervention,the distribution of phlebitis level and local pain degree had statistical difference between the two groups (Z=2.57,2.53;P=0.01);the observation group was superior to the control group in the aspects of phlebitis lesion degree and local pain alleviation;WBC,MPV and PDW in the observation group had statistical difference between before and after intervention;WBC,PLT and PCT in the control group had statistical difference between before and after intervention (P<0.05);PLT count was positively correlated with PCT in the two groups (r=0.952,P<0.05);the CRP level and WBC count after intervention had no statistical difference between the two groups(P>0.05).Conclusion 2% anisodamine can effectively prevent and alleviate the occurrence of 5-FU caused chemotherapy phlebitis and local pain.At the same time,PLT can provide a basis for preventing chemotherapy phlebitis.

Antigens, CD34 ; metabolism ; Choriocarcinoma ; pathology ; Diagnosis, Differential ; Female ; Hemangioma ; metabolism ; pathology ; Humans ; Keratin-18 ; metabolism ; Mesenchymoma ; pathology ; Placenta ; pathology ; Placenta Diseases ; metabolism ; pathology ; Platelet Endothelial Cell Adhesion Molecule-1 ; metabolism ; Pregnancy ; Pregnancy Complications, Neoplastic ; metabolism ; pathology ; Young Adult

Adult ; Aged ; Aged, 80 and over ; Blood Viscosity ; drug effects ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Hemorheology ; drug effects ; Humans ; Male ; Middle Aged ; Phytotherapy ; Pulmonary Heart Disease ; blood ; drug therapy

MicroRNAS( miRNAs) are a class of single strand, small non-coding RNAs about 22 nucleotides, which have the function to regulate gene expression post-transcriptionally and control the biological processes,such as proliferation, differentiation and apoptosis. Recent studies indicate that miRNA plays an important role in tumor involved in invasion and metastasis. This article mainly reviews the feature of miRNA and its effect in metastasis or recurrence of breast cancer.

The literature courses in military medical university have two main difficulties:fuzzy teaching purpose and single teaching forms. To tackle the two difficulties,firstly,the literature courses should have specific aim which includes medical characteristics and practicality. Secondly, the teachers should choose reasonable materials and adopt effective teaching forms and then better teaching effect can be obtained.

Modern Chinese course in the Third Military Medical University adhered to post com-petency oriented function for curriculum. It simplified, merged and enhanced the traditional Chinese teach-ing content, to help students to establish a standardized use of language awareness, and establish a sense of cultural identity, which helped medical students learn and appreciate literary works from all countries and famous narrative medical text, improved their moral sentiments, and aroused their empathy and empathy for the response. Under the guidance of the basic theory of spoken language, scientific, systematic, strict oral expression skills and effective doctor-patient communication skills training were carried out for medical stu-dents, so as to cultivate medical students' humanistic spirit and the scientific spirit.

Mutation and overexpression of the tumor suppressor gene product, p53, is believed to play an important role in the development of human malignant tumors. Many studies shows that overxpression of the mutant p53 gene product is common in human malignant tumours including esophageal cancer. However, the prognostic significance of overexpression of p53 gene is not well defined. In this study, we have investigated the overexpression of p53 gene product in 174 esophageal squamous cell carcinoma collected from Sichuan Cancer Hospital, Chengdu, China. 48.9% of these esophageal squamous cell carcinomas were positive for p53 staining. Correlations of overexpression of p53 with clinicopathological features including histological type and grade, clinical staging, age and sex was analyzed in all specimens. The prognostic significance of p53 stained esophageal squamous cell carcinoma was analyzed in 111 of these patients follow-up for five-year. Significant statistical correlations were observed between p53 positive and poor prognosis analyzed by Cox proportional hazard regression analysis, (F=0.04). No statistically significant differences were observed between p53 overexpression and the clinicopathological factors including age, sex, differentiation and clinical staging of the cancer, but patients with Vositioly expressed p53 has a poorer prognosis than those with negative expression. The present study indicate that overexpression of p53 may be a useful independent prognostic factor in esophageal squamous cell carcinoma at its early stage.

Objective To analyse CT appearances of fibroma and fibrosarcoma and to provide evidences for clinical diagnosis and treatment.Methods 8 cases with surgically-and pathologically-proved hard fibroma(nasal cavity,maxillary sinus and soft palate each and all 2 cases)and fibrosarcoma(nasal cavity and maxillary sinus each and all 1 case)were studied with retrospectively analysis.The scanning parameters were 5 mm thickness and interval for axial scanning.Results CT appearances of fibroma were single circular,semicircular or elliptical soft tissue masses which usually had homogeneous density,clear margin,thin and full envelope,wide base or a pedicel and slight or middle enhancement after contrast.The tumors grew distensibly,bones near the mass were constricted and thinned or absorbed but never destroried and the structures nearby were deviated but not involved.Fibrosarcoma showed such common CT manifestations as other malignant tumors in the same locations.Conclusion CT appearances of fibroma has some features,they are different from more common benign lesions.Fibrosarcoma can not be differeciated from other maglinant tumors,thier diagnosis must depend on pathology.

Fifteen cases of periprosthetic femoral fractures of after total hip arthroplasty (THA) in Department of Orthopedic Surgery, Guangdong People’s Hospital between May 1997 and May 2007 were retrospectively analyzed. According to the classification of Vancouver, there was 1 case of type AG, one of type AL, 3 of type B1, 5 of type B2, 3 of type B2, and 2 of type C. Two cases of type A were treated with conventional method, and cases of type B1 and C were treated with open reduction and internal fixation. Cases of type B2 and B3 were treated with a long-stem cemented prosthesis revision plus allograft cortical strut bone. Through 3-12 months follow-up, all the fractures were healed, and bone allografting was successful, but with high rate of complications which were curable. The new prosthesis stem was fixed well. Excellent and good rate of Harris scores for hip joint was 73.3%. Therapy selection based on Vancouver classification for periprosthetic femoral fracture after total hip arthroplasty is an effective method.