1.Synthesis of polylactic acid
Chinese Journal of Tissue Engineering Research 2008;12(23):4594-4596
Polylactic acid (PLA) is a biocompatible and biodegradable polymer, thus it is widely used in the medical area and is much more attractive. There are two main methods to synthetizing PLA, ring-opening polymerization of lactide and condensation polymerization of lactic acid. In this paper, the process of the new research of the PLA synthesis was reviewed. Beside, the PLA synthesis methods of reactive extrusion and direct melting polycondensation were introduced, which are two high efficiency methods. Finally, the foreground of PLA synthesis was prospected.
2.Research of helicobacter pylori in gastric cancer development mechanism
Cancer Research and Clinic 2011;23(7):500-502
Numerous studies showed that Helicobacter pylori (HP) infection and gastric cancer have a correlation, which is a important factor to influence the development of gastric cancer, with scholars' intensive research, it is found that the way of HP acting on gastric cancer is complicated and diverse, this review summarizes the role of HP in mechanism, correlation factor and action way of gastric cancer.
3.Vincristine inhibits HL-60 Cells proliferation by interfering the metabolism of phosphoinositides
Chinese Pharmacological Bulletin 1987;0(03):-
Human promyelocytic leukemia HL - 60 cells labelled with 3H - inositol were treated with vincristine (VCR), it was found that the radioactivity of 3H-phosphatidyl inositol - 4-phosphate (PIP) and 3H - Phosphatidyli-nositol - 4,5 - bisphosphate(PIP2) had no obvious change, but that of 3H-phosphatidyl inositol (PI) decreased rapidly, only accounted for 38. 55%~61.01% of the control during 1~ 120 min of the treatment. It showed that VCRdid not affect the activity of PI kinase and PIP kinase, but enhanced the hydrolysis of PI of HL - 60 cells. The inhibitorty effect of VCR upon cell proliferation and DNA synthesis was observed after above biochemical changes,these results suggest that VCR may inhibit HL-60 cells proliferation by interfering the metabolism of phosphoininositides.
4.Exploration for the comprehensive management and psychological influence in children with asthma
Journal of Clinical Pediatrics 2001;(1):12-13
To explore the effect of comprehensive management on psychological influence in children with asthma, 60 cases with asthma was administrated by WHO global comprehensive strategy for the management of asthma including the persistent use of beclomethaone with the intermittent inhalation of salbutanmol, the lung function monitored by peak flow meter, the detection and avoidance of the induced factors, the management of the social education and the psychological intervention. All children on comprehensive management were followed one year for observation. The results showed that the rate of the total effect was 98.3%. There were all decrease significantly in the rate of the hospitalization, the rate of the emergency, and the rate of the absence for school. It was obvious that asthmatic children and their parents's confidence for the treatment of asthma enhanced significantly.Their psychological disturbance, the school grade, and the life quality were also obtained advanced improvement.
8.Relation of micro-RNA and carcinogenesis.
Bo FAN ; Liang ZHANG ; Chi MA
Chinese Journal of Oncology 2012;34(6):401-404
9.Autophagy pathways and key drug targets in Parkinson's disease.
Liang OUYANG ; Lan ZHANG ; Bo LIU
Acta Pharmaceutica Sinica 2016;51(1):9-17
Parkinson's disease (PD) is a common neurodegenerative disorder associated with aging. Great progresses have been made toward understanding the pathogenesis over the past decades. It seems that both genetic factors and environmental factors contribute to PD, while the precise pathogenesis still remains unknown. Recently, increasing evidence has suggested that autophagy dysregulation is closely related to PD. Dysregulation of the autophagic pathways has been observed in the brains of PD patients or in animal models of PD, and a number of PD-associated proteins, such as a-synuclein, Parkin and PINK1, were found to involve in autophagy, suggesting a link between autophagy and pathogenesis of PD. In this review, we summarized the role of PD-associated proteins in autophagy pathways. In addition, we described the efficacy of autophagy-modulating compounds in PD models and discussed promising strategies for PD therapy.
Animals
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Autophagy
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Humans
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Parkinson Disease
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physiopathology
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Protein Kinases
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metabolism
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Ubiquitin-Protein Ligases
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metabolism
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alpha-Synuclein
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metabolism
10.Clinical analysis of acute Avermectins poisoning.
Peng JI ; Hai-Bo ZHU ; Yong LIANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(7):437-437
Acute Disease
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Adolescent
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Adult
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Aged
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Child
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Female
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Follow-Up Studies
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Humans
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Ivermectin
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analogs & derivatives
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poisoning
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Male
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Middle Aged
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Retrospective Studies
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Young Adult