The animal experiments,clinical researches and epidemiological investigations indicated that genistein has the effect for prevention and treatment of osteoporosis,cardiovascular disease and cancer.Genistein can inhibit cellular and humoral immunity and can regulate cell apoptosis.The chemical structure,biological effects and the mechanism of genistein attracted much attention.The current research advance on genistein was summarized and the prospect on the theoretical significance,clinical importance was presented in this paper.

Hypothyroidism is one of the most common endocrine disorders in childbearing or pregnant women.Gestational hypothyroidism can increase the incidence rate of the variety of pregnancy complications and adverse pregnancy outcome.It also can make adverse effects on the fetus and neonate,such as death,placental abruption,fetal malformation,intrauterine growth retardation and preterm,low birth weight,neonatal respiratory distress syndrome,it can also cause abnormal thyroid function of neonate,severely can cause nerve,mental,physical and mental developmental abnormalities and even death.Therefore,it is recommended that childbearing women who are at high risk for pregnancy should strengthen to monitor pregnancy thyroid function and treat as soon as possible in order to reduce the adverse effects on offspring.

OBJECTIVE: To evaluate the current situation and trend of narcotic drug use in our hospital where the authors work in order to provide the reference for scientific management and rational use of these drugs. METHODS: The yearly amount of narcotic drugs administered in the whole hospital, the yearly amount in the separate departments, as well as drug expenditures and ratios between January 2002 and November 2005 were added up and analyzed statistically. RESULTS: The amount of bucinnazine use dominated in the first. The amount of morphine for oral use was increasing year by year. The amount of fentangl transdernal patch use was also bigger and increasing rapidly. However, the amount of pethidine and morphine for injection use was decreasing. CONCLUSION:Analgetics for oral and transdermal use will be the main categories of analgetics in the future.

Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid, Chronic-Phase ; genetics ; Lymphoma ; classification ; diagnosis ; pathology ; Male ; Neoplasms ; genetics ; metabolism ; pathology ; Oncogene Proteins ; metabolism ; Prognosis ; Prostatic Neoplasms ; genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Translocation, Genetic ; Tumor Suppressor Proteins ; metabolism

Objective To explore the relationship between CT imaging features and clinical pathology of thyroid carcinoma. Methods The clin-ical data of 42 cases of patients with thyroid carcinoma treated in our hospital from Jaunuary 2014 to October 2015 were analyzed retrospectively. All patients underwent CT imaging before operation. The CT imaging features and surgical pathology results were compared and analyzed ,and the relationship between the two groups was studied. Results CT imaging showed a total of 40 cases of primary lesions,32 cases of uneven density, 30 cases of irregular shape,28 cases of edge blur,19 cases of calcification,25 cases of tumor invasion of the surrounding organs,and the surgical pathology results showed a total of 18 cases of papillary carcinoma,15 cases of undifferentiated carcinoma,6 cases of follicular carcinoma,3 cases of medullary carcinoma,22 cases of tumor invasion of the surrounding organs. The accuracy of CT imaging was 88.10%-95.24%,and the sensitivi-ty was 75.00%-93.75%,and the specificity was 91.30%-100.00%. Conclusion The CT imaging features of thyroid carcinoma and its clinical pa-thology are related. CT has high accuracy ,sensitivity and specificity in the invasive examination of tissue structure ,which is worthy of clinical appli-cation.

Objective To study the clinical analysis in the neonatal hypoxic-ischemic encephalopathy (HIE)for evealuation of the severity of brain injury and prognosis. Methods The manifestation,laboratory findings,outcomes of 117 HIE were analyzed. Results Manifestations of HIE in 117 infants included 3 groups(minor level,moderate level,severe level). There was no significant difference in the weight and gestation-age among 3 groups.Scores of Apgar lowing,which Was marked in the severe level(P＜0.01). There was significant difference in the level of pH and PaCO2(P＜0.01). There was significant difference in the level of blood GLU and BE reduced aboviusly in the severe level,and in the level of BUN,CK-MB,CK increased aboviusly in the moderate and severe level,among all(P＜0.01). 69 patients were taked CT on the brain,the abnormal rate of which was 82.6%. The abnormal rate of CT on the brain increased 100% changing with the severity of brain injury on HIE especially in the moderate and severe level. Conclusion The prognosis of the minor level of brain injury on HIE is the best. The prognosis of the moderate-level group who was treated reasonably and enough,is better mostly.

Objective To discuss the death causes in patients diagnosed initially as mild to moderate craniocerebral trauma. Methods A retrospective study was done on 44 deaths, who arrived at the emergency department with a mild or moderate craniocerebral trauma from 2004 to 2008. There were 35males and nine females at age range of 19-85 years (average 53 years). There were 17 patients with Glasgow coma score (GCS) 13-15 points and 27 with GCS 9-12 points. The causes of injury included road traffic accidents in 18 patients, tumbling in 18, falling from height in six and unknown factors in two respectively. Of all, 18 patients underwent surgical intervention and 26 received conservative therapy.Results The causes of death were cerebral hernia in 25 patients (57%), various complications in 15(34%), multiple trauma in two (5%) and sudden death in two (5%) respectively. Conclusions The primary death cause is cerebral hernia in the patients with mild to moderate craniocerebral trauma.Attention should be paid to prevention and control of complications and multiple trauma during treatment of primary head injury. The prognosis may be badly affected by human factors.

Objective To study the effect of 3％ hypertonic saline(HS) and 20％ mannitol on cerebral oxygen metabolism in patients undergoing neurosurgery for supratentorial glioma.Methods 56 patients undergoing neurosurgery for supratentorial glioma were evenly divided into two groups.Group A(n =28) was treated by 3％ hypertonic saline(5.35ml/kg).Group B (n =28) was treated by 20％ mannitol(1 g/kg).CSFP was tested before hypertonic saline or mannitol infusion (T0),immediately (T1),15,30,60,120min after infusion (T2 ～5).Various blood-gas indexes were observed at To,T3 ～5.CaO2,CjvO2,Da-jvO2 and CERO2 were calculated.Results CSFP significantly dropped from T2 to T5 in both groups (P ＜ 0.05).Da-jvO2 and CERO2 were significantly reduced at T4～5 in both groups (P ＜ 0.05).There was no significant difference between the two groups.Conclusion 3 ％ HS is as efficient as 20％ mannitol in reducing intracranial pressure and improving cerebral oxygen metabolism in patients undergoing neurosurgery for supratentorial glioma.

Objective To investigate the application of numerical simulation technique in supraorbital and frontal osseous defect.Methods The data of the patients with complex supraorbital and frontal osseous defects were obtained by helix CT scan.Numerical model based on the data was built up by computer.And the true model was produced by Rapid Prototyping.Being stimulated before this operation.the model was directly used in the operation.Results All of these 12 patients(one of defect of brow,four fracture of brow and zygoma,seven of old fracture of brow and zygoma)in this study were satisfied and their brows were symmetry after operation.All of them were satisfied after 1 or 2 years,without implantation exposure and transfiguration except one with infection.Conclusion Based on numerical technique difficulties of repairing,complex supraorbital and frontal osseous defect could be resolved by such process as collecting the bone data,stimulating operation by true models,and producing implantation before the operation.The accuracy of these operations can be improved.

Objective To discuss the changes of quality of life and influence factors in patients with multidrugresistant pulmonary tuber-culosis. Methods Using the SF-36 scale of 80 normal subjects and 80 cases of MDRTB patients before and after treatment and quality of life score total score evaluated dimensions. Results Between the patients with MDR-TB and the control in the total Qol scores and eight dimensionality, there were significant differences(P＜0.01), total Qol scores and eight dimensionality in 3 months or 1 year after treatment were higher than before therapy,there were significant differences(P＜0.01 ). Between 1 year after therapy in the total Qol scores and PF, PR, GH, VT, SF, ER, MH, dimensionality were lower than control groups, there were significant differences(P＜0.05 ). The main factors affecting the Qol of patients with MDR-TB were cultural level, kinds of drug resistant and reduction of counts of white blood cell. Conclusion The correlation between quality of life and education, the number of drug resistance, reduction of white blood cell in patients with multi-drugresistant pulmonary tuberculosis.