The basic physical teaching is an important part of the training of students' scientific quality.For the advance of the teaching quality,we have to improve the traditional teaching pattern and the evaluation way of the physical quality.This paper offers a teaching method of in-depth dissemination for the basic physics and proposes an evaluation way of physical quality by the theory of attribute distinguishing.

Lipodystrophies represent a heterogeneous group of diseases characterized by varying degrees of body fat loss and predisposition to insulin resistance and metabolic complications such as diabetes mellitus,hypertrigly-ceridemia and hepatic steatosis. The lipodystrophies can be divided into generalized,partial or local,depending on the degree and locality of the observable fat loss;moreover,the generalized and partial divisions can be partitioned further into congenital or acquired forms. Until now,11 genetic factors including AGPAT2,BSCL2,CAVI,PTRF,PPARG, LMNA,ZMPSTE24,AKT2,CIDEC,PLINI and WRN were reported to be involved in congenital lipodystrophies. The most prevalent subtype of acquired lipodystrophy currently occurs with prolonged duration of protease inhibitor - contai-ning,highly - active antiretroviral therapy in human immunodeficiency virus(HIV)- infected patients. Other types of acquired lipodystrophies are mainly autoimmune in origin and display complement abnormalities. The current manage-ment includes cosmetic surgery and early identification and treatment of metabolic and other complications with diet, exercise,hypoglycemic drugs,and lipid - lowering agents. Metreleptin treatment demonstrated remarkable clinical effect and good tolerance.

Objective To investigate whether AZD1152 (AZD),the selective inhibitor of aurora kinase B,may play a role in the treatment of cisplatin-resistant ovarian carcinoma when administrated alone or in combination with cisplatin.Methods Hey (cisplatin-resistant ovarian cancer cell line) cells were analyzed.According to the treatment plan,Hey cells were divided into four groups (AZD group,cisplatin group,AZD + cisplatin group and control group).Methyl thiazolyl tetrazolium (MTT) assay was used to test the cells proliferation,caspase-3/7 activity analysis was used to analyze cells apoptosis,and fluorescence insitu hybridization (FISH) assay was used to determine the copy the number of chromosome 7 and checked the copy numbers of hTERC gene and C-myc gene.Results MTT test showed that proliferation of AZD group was lower than that in control group(P ＜ 0.01).The cells proliferation with the treatment with 10 and 20 nmol/L AZD for 24 hours was (81.4 ± 3.6)％ and (81.4 ± 3.6)％ respectively,and the cells proliferation for 48 hours was (43.1 ± 2.0) ％ and (38.5 ± 1.6) ％ respectively,which was significantly lower than control group (100％,P ＜ 0.01) ; Treated with the same concentration of AZD,inhibition of proliferation was significantly enhanced as the time extended (P ＜ 0.01).Proliferation in group AZD+cisplatin was lower than that in cisplatin group (P ＜ 0.01) which suggest that there were additive effects after combined AZD with cisplatin.Compared with control group,caspase-3/7 activity in AZD group increased significantly (P =0.000),and the same results was seen between AZD ± cisplatin group and cisplatin group or AZD group (all P ＜ 0.01).Compared with cisplatin group or control group,the copy numbers of hTERC,C-myc and the number of chromosome were significantly increased in AZD group and AZD + cisplat group (all P ＜ 0.05).Conclusions AZD could inhibite ovarian cancer cells proliferation and induce cells apoptosis significantly.AZD alone or in combination with cisplatin may result in the increased cells polyploidy.

Objective:To evaluate the clinical efficacy of left left atrial function for the healthy by using real-time three plane ultrasonic imaging in.Methods: The three plane real-time ultrasound imaging was used for evaluation healthy people of left atrial function in 32 adults (including storage volume of left atrium, left atrial pipeline volume, left ventricular ejection fraction). At the same time, the two-dimensional echocardiography was also used to detect the parameters which were to compare two methods of correlation and consistency.Results:Two methods of ultrasonic examination in LARV, LACV and LVEF indicators have no obvious difference; LARV, LACV and LAEF in three plane image and two-dimensional ultrasound images show good correlation, the correlation coefficient rLARV=0.82, rLACV=0.85, rLVEF=0.88,P<0.05).Conclusion:Real-time three plane ultrasound imaging and two-dimensional echocardiography in the assessment of left atrial function of normal people have a good correlation.

Objective To investigate the effects of icariin on the expressions of osteoprotegerin(OPG)and receptor activator of nuclear factor-kB ligand(RANKL)mRNA in rat osteoblasts cultured in vitro.Methods Calvarial osteoblasts were obtained from newborn SD rats aged＜24 h by trypsin-collagenase digestion method. After treatment with different concentrations of icariin(10~(-10)-10~(-4) mol/L)for 48 h,total RNA was isolated from osteoblasts.Expressions of OPG and RANKL mRNA were detected by semiquantitative RT-PCR.Results Icariin remarkably increased OPG mRNA levels and decreased RANKL mRNA levels in calvarial osteoblasts in a dose- dependent fasion with a maximum effect at a concentration of 10~(-7)mol/L(P＜0.05).Osteoblasts pre-treated with icariin prevented the inhibitory effect of dexamethasone on OPG mRNA(0.570?0.093 vs 1.083?0.081)and the stimulative effect on RANKL mRNA(1.079?0.050 vs 0.718?0.082)(both P＜0.05).Conclusion Icariin upregulates OPG expression and downregulates RANKL expression in osteoblasts,which may explain the beneficial role of icariin in preventing and treating osteoporosis.

Adult ; CD56 Antigen ; metabolism ; Carcinoma ; metabolism ; pathology ; surgery ; Carcinoma, Medullary ; pathology ; Carcinoma, Papillary ; metabolism ; pathology ; DNA-Binding Proteins ; metabolism ; Diagnosis, Differential ; Female ; Humans ; Paraganglioma ; metabolism ; pathology ; Thyroid Neoplasms ; metabolism ; pathology ; surgery ; Thyroidectomy ; methods ; Transcription Factors ; Triglycerides ; metabolism

Objective To study the method of internal boundary parameters identification of middle ear.Method The numerical model is created using CT technology.Based on Matlab tools,the neural network for identifying internal boundary is proposed.Result The uniform pressure of 105 dB is applied at the outside of the tympanic membrane,and the harmonic analysis is calculated on the model to take the training samples.The internal condition parameters are identified using the good neural network.Conclusions The investiga-tion shows that the inverse method reveals a fast convergence and a high degree of accuracy.

Objective:To investigate the knowledge, attitudes and practice of child sexual abuse (CSA) prevention education in parents of elementary school pupils.Method:Two hundred and seventy one parents were surveyed by anonymous self-administered questionnaire in five classes of grade 1 to grade 5 of a elementary school. The questions about awareness of CSA and communications on how to prevent CSA with their children were asked.Result:Among this sample, 93.6% of parents approved of school CSA prevention education. Overall, about half parents lack of knowledge of CSA prevention, the communications with their children were also not enough. Only 1.8% of parents had provided books or audiovisuals about CSA prevention for their children. The scores of knowledge, attitudes and practice of CSA prevention education of parents whose parents addressed this in their childhood were significantly higher than those of parents who had no this experience.Conclusions:The research of CSA prevention education in elementary school should be paid more attention, to produce related books and audiovisuals as soon as possible, to increase parents' awareness of CSA prevention.

Objective To understand the effects of environmental pollution on blood lead levels of children.Methods The blood lead levels of605children aged2-7in6urban districts of Harbin and307children aged2-7in Jixi were deter-mined by graphite furnace atom absorption spectrophotometry during the period from April to June in1999.Results The data on blood lead levels of children in two cities showed both positive skewness distribution.The geometric means of blood lead lev-els of children were0.354?mol/L in Harbin and0.441?mol/L in Jixi,the medians were0.369?mol/L in Harbin and0.440?mol/L in Jixi,the values of P 95 were1.575?mol/L in Harbin and1.304?mol/L in Jixi.The children with blood lead levels of≥0.483?mol/L accounted for44.5%of total observed in Harbin and44.9%in Jixi.Conclusion Environmental lead pollution had coused potential adverse effects on preschool children health.

Objective: To assess the effect of taurine supplementation on behavior of young rats exposed to low-level lead. Methods: Wistar dam rats were randomly divided into three lead+Tau(0.5%, 1.0% ,1.5%)groups, lead group and control group.Dams of three lead+Tau groups were fed with food containing 0.5%,1.0%,1.5% taurine respectively from d 9 of gestation. Lead+Tau groups and lead group dams were given water containing 0.14% PbAc 2 ad lib. from d 16 of gestation to weaning of the off spring on d 25 post partum. The pups continued taking same food and water. The neurobehavioral function of pups was tested. Results: (1) Taurine supplementation could significantly decrease accumulation of lead in the brain of young rats. (2)Taurine supplementation was able to prevent Pb-induced retardation on behavioral development, and also learning and memory damage in young rats.(3) In all selected six brain regions, the content of NA and DA was decreased in lead group compared with control group. The content of NA in all six brain regions and DA in pituitarium, cerebellum and cortex in 1.0% taurine supplementation group could be restored to normal. The content of ACh in hippocampus and cortex was decreased in Lead compared to Cont group, and which could be corrected by Tau supplementation. Conclusion: The results suggest that taurine has protective function against Pb-induced toxicity and can protect the nervous system against Pb-induced damage in the development of young rats.