The human fragile histidine triad (FHIT) gene is a tumor suppressor gene,which is located at chromosome region 3p14.2.The fragile site FRA3B of the FHIT gene is the most unstable site.FHIT can promote apoptosis,and inhibit cell proliferation and tumorigenesis.High methylation status,loss of the various sections of the FHIT gene,changes of the fragile site FRA3B and abnormalities of FHIT transcripts can result in gene afunction,and then promote the development and progression of various types of cancers.Transfecting wild-type FHIT into tumor cells with low or lacking endogenous FHIT expression can induce apoptosis.The combined treatment with other genes may provide a new insight for the treatment of tumors.

As a member of homeobox gene family,HOXC is expressed in many organs and can regulate gene expression,cell differentiation and morphogenesis.Abnormality of its function is closely related to the prognosis of leukemia,breast cancer,renal cell carcinoma,prostate cancer and so on.

Voluntary control of saccadic eye movements is a kind of saccades controlled by conscious and always used to investigate the brain areas related to saccades and ability of response inhibition and work memory.Researching the neural mechanisms of voluntary control of saccadic eye movements could provide a basis to study the advanced cognitive function of brain and facilitate to explore basic neural mechanisms of abnormal saccadic in brain disorders.As neuroimaging technologies develops,intensive studies about the neural mechanisms of voluntary control of saccadic eye movements have been made great progress.It is showed that several brain areas such as prefrontal cortex,subcortical areas and parietal cortex mainly in participate.These multiple brain regions are involved in voluntary control of saccadic eye movements at different stages.Antisaccades and memory-guided saccades including different brain regions because of their different characteristics of saccadic.The future direction of the research is to combine study with neural imaging technology,and to study more about the brain regions and their functional connectivity involved in voluntary control of saccadic eye movements.

Objective To investigate the effect of electroacupuncture on motilin (MOT) and somatostatin (SS) in rats with diabetes gastroparesis (DGP). Methods One hundred clean healthy SD rats with negative urine glucose were chosen. After they were fed for three days and into a stable state, 30 rats were randomly selected as a control group. The other 70 rats were used as an animal model of insulin-dependent diabetes made with streptozotocin. At 10 weeks after model making, rats as successful models were randomly allocated to model and treatment groups, 30 rats each. The model group received no treatment and the treatment group, electroacupuncture at points Zusanli, Zhongwan and Weishu. Serum and antral MOT and SS were measured in every group before and after treatment. Results There were statistically significant differences in body weight and gastrointestinal propulsion rate between the treatment or model group of rats and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). There was a statistically significant difference in blood glucose value between the treatment or model group of rats and the control group after model making and at 10 weeks and the end of treatment (P<0.01). There was a statistically significant difference in blood glucose value between at the end and 10 weeks of treatment in the treatment group (P<0.01). There were statistically significant differences in serum and antral MOT and SS contents between the treatment or model group and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). Conclusions Electrocupuncture can markedly increase serum SS and antral MOT and decrease serum MOT and antral SS to ameliorate high blood motilin and somatostatin in DGP rats.

Objective To understand the basic structure of undergraduate nursing education teachers in Heilongjiang province in order to provide the scientific reference for the construction of our provincal nurse teachers troop.Methods Using self-made questionnaires and in the form of mail,the investigation about the basic structure and existing problems of undergraduate nursing education teachers in Heilongjiang province was carried out from December 2006 to March 2007.Results The finding was that at present some disparities existed between the basic situation of the teachers troop and higher nursing education development request.Number of professional and part-time teachers bad very wide difference;the professional title distribution was unreasonable in various schools and the proportion of double-teacher type was somewhat low,education background levels were different and the teachers who had hish education qualification were scarce;the teachers'insufficient teaching experience caused the poor teaching basic skills and so on.Conclusions There exists certain problems in undergraduate nursing education teachers in Heilongjiang province.Not until the positive countermeasures according to the cause were taken,can we construct a nursing teachers troop which has the required education background,the reasonable structure and the developmental potential.

Objective To investigate the characteristics of interactive effects of magnetic field of two intensities combined with high-temperature and noise simulating ship environment. Methods Orthogonal trial design of three factors and two levels and variance analysis method were employed. The rabbits and rats were grouped into eight combined exposure groups and eight controls, respectively, according to orthogonal table L_8 (2~7). Animals in all groups underwent the experiments and the indices were determined at the same time. Results Analysis of the radius of capillary vessels on rabbit's conjunctiva and HSP70 of rat's liver and spleen showed that magnetic field was the dominant factor (P

Objective: Evaluation the clinical characteristics of Chinese reading disorder children.Methods:Use WSIC-CR, PRS and the questionnaire for parents on children's reading and writing abilities to investigate and evaluate 17 Chinese children with SRD (specific reading disorder) and 32 normal children.Results:The VIQ、FIQ、VC、M/C of Chinese SRD children scored in WISC-CR were lower than normal children(98.3?13.5/111.7?13.7,97.1?14.5/110.2?14.3,40.4?9.2/47.6?7.7,25.9?6.3/32.0?7.3,OR=0.88~0.94,P

Objective: To explore the eye-movement characters and the visual cognitive processing traits of Chinese children with reading disorder (RD) during apperceiving pictures. Methods: 14 children with reading disorder and 14 normal controls were collected. Their eye-movements during apperceiving pictures were recorded with Eye-link II High-Speed Tracker. Results:The only significant difference between the two groups existed in the score of average saccade amplitude for picture 3 (RD children scored less 3.79?0.69/ 4.86?1.67,t=-2.29,P0.05).Conclusions:The remember and process capability to the pictures are not the main characters of the Chinese RD children. If the background of picture is complicated, the attention span of children suffered RD will be more limited, and their fixation efficiency will be depressed.

Objective:To explore the eye-movement characteristics and the visual cognitive processing traits of Chinese children with reading disorder (RD) during reading articles in order to offer reference for measures designed for diagnosis and therapy.Methods: Recorded the series data of eye-movement with Eye-link Ⅱ when the children read articles, and analyzed relevant parameter of eye-movement.Essay one is a narrative article chosen from the textbook of the second grade, whose content is simple and there are subject sentences.Essay two is a narrative article chosen from the Neuropsychology, which is an article used to test optic aphasia patient, and the essay has no subject sentence.Results: ①Results of reading comprehend: For the RD children, the reading score of the first narrative article was lower than that in the normal control group (2.2?1.1/2.9?0.5,t=-2.2,P0.05).For the RD children, the reading time of the two articles was longer than that in normal control group (for article one: 119.3?44.1/63.4?20.4, t=4.3,P

Objective To identify knowledge structure and knowledge requirement of undergradu-ate course nursing teachers in our province, and offer corresponding training suggestions to construct teaching staff with reasonable knowledge structure. Methods The author adopted investigation method by giving questionnaire to 181 nursing teachers that assumed undergraduate course nursing education, the main content included general circumstance, knowledge structure and knowledge requirement of un-dergraduate course nursing teachers in Heilongjiang province. Results Nursing teachers in the fields of knowledge all had low score items, they most lacked foreign languages and expertise knowledge, the ur-gent need was to improve teaching theory and practice of teaching ability. Conclusions Nursing teach-ers possess some weak links in all areas of knowledge to different' extent, and the knowledge structure needs to be further improved. The college leaders should provide targeted training combined with nursing teachers' knowledge needs.