Objective To evaluate clinical efficacy of acupuncture combined with herbs-deparated moxibustion meridian sinew node to treat the contracture and fatigue of limb muscle after stroke.Methods Seventy two patients with limb faigure & muscle contracture after stroke in conformity with the incorporation standard were randomly divided into a treatment group and a control group.The patients in the treatment group were subjected to the acupuncture combined with herbs-deparated moxibustion meridian sinew node, and patients in the control group were subjected to conventional acupuncture and infrared therapy.The activity of daily living scale (ADL), simplified Fugl-Meyer movement function score, neurological impairment degree score, modified Ashworth scale (MAS) score, clinical spasticity index (CSI), patient-reported outcomes (PRO) of patients in both groups before treatment and after 4 weeks of treatment were observed.Clinical efficacy was evaluated.Results The total effective rate of the treatment group was significantly better than the control group (86.1％ vs.55.6％;x2=8.134, P=0.004).The limb spasm I level improvement of patients in the treatment group (30.6％ vs.8.3％, X2=4.345) was better than that in the same group before treatment (P＜0.05).ADL score of patients in the treatment group after treatment increased (58.37 ± 10.68 vs.54.25 ± 9.57, t=1.720) when compared to that before treatment, simplified Fugl-Meyer score of patients in the treatment group after treatment increased (75.25 ± 12.54 vs.66.36 ± 10.99, t=3.199) when compared to that before treatment, the rise condition occurred, the score of neurologic impairment degree of patients in the treatment group hit (7.47 ± 1.06 vs.11.24 ± 2.19, t=9.290) when compared to that before treatment, decrease conditions of patients in the treatment group were better than those of patients in the control group (P＜0.05).The tendon reflex in CSI index of patients in the treatment group after treatment increased (2.71 ± 0.22 vs.3.08 ± 0.24, t=6.819) when compared to that before treatment, the muscle tension of patients in the treatment group increased (4.34 ± 0.32 vs.5.83 ± 0.35, t=18.852) when compared to that before treatment, the clonus of patients in the treatment group after treatment increased (1.22 ± 0.28 vs.1.89 ± 0.35, t=8.969) and PRO score of patients in the treatment after treatment increased (19.22 ± 4.47 vs.228.27 ± 4.94, t=8.151) were significantly lower than that of patients in the control group (P＜0.05).Conclusion The acupuncture combined with herbs-deparated moxibustion meridian sinew node can improve the movement and life of patients with stroke and muscle weakness & contracture, and its efficacy is better than conventional acupuncture combined with acupuncture and infrared therapy.

Objective To compare the curative effect of hepatocyte growth factor(HGF) in treatment of infant hepatitis syndrome (IHS) caused by cytomegalovirus with ganciclovir.Methods Sixty-eight cases with infant hepatitis syndrome caused by cytomegalovirus from neonatology department of our hospital from September 2010 to September 2014 were randomly divided into two groups, the observation group (32 cases)took HGF and ganciclovir therapy and the control group (36 cases) only received ganciclovir treatment Both groups were given conventional guard liver therapy.After one month of treatment, liver function, cytomegalovirus DNA content,extinction time of jaundice, treatment efficiency and the adverse reaction rate were evaluated for two groups.Results Liver function of children in observation group improved significantly after treatment compared with the control group, CMV-DNA quantitatively lower than the control group, the extinction time of jaundice was earlier than the latter,and the overall treatment efficiency was higher in observation group (P ＜0.05);The adverse reaction has no significant difference between two groups (P ＞ 0.05).Conclusion HGF combined with ganciclovir treatment can significantly improve liver function in patients of IHS caused by cytomegalovirus infection, and can collaboratively reduce viral load.Symptoms subside quickly with fewer adverse reactions, which is worthy of clinical promotion.

OBJECTIVE To investigate the infection of Mycoplasma and drug resistance in the patients of nongonococcal urethritis(NGU)in the local area.METHODS Totally 414 specimens in the patients of NGU were collected,cultured and tested for drug sensitvity.RESULTS From them there were 284 patients who had Mycoplasma(68.60%).The simple infection of Ureaplasma urealyticum(Uu)was 90 cases(21.74%) and that of Mycoplasma hominis(Mh) was 52 cases(12.56%).The mixed was 142 cases(34.30%).The result of drug sensitivity showed that sensitivity of Mycoplasma to minocycline(Minocin) was the highest,then was to doxycycline.Ciprofloxacin was with the highest drug resistance,then were sparfloxacin and erythromycin.CONCLUSIONS The infection rate of Mycoplasma in the patients of NGU is in a rising tendency;Mycoplasma are severely resistant to ciprofloxacin,sparfloxacin,and erythromycin,and have multi-resistance.It is important to culture and test the drug sensitivity of Mycoplasma.To control the Mycoplasma infection and supervision management of antibiotics is a urged and important task for us.

Objective To evaluate the levels of pulmonary surfactant protein D (SP-D) and 56-kD human type Ⅰ protein(HTI-56) in bronchoalveolar lavage fluid and serum of children with mycoplasma pneumoniae pneumonia,as well as their potential as biomarkers of mycoplasma pneumoniae pneumonia.Methods A retrospective study was conducted in 57 children with mycoplasma pneumoniae pneumonia from June 2011 to June 2016 in our hospital.In this study,the levels of SP-D and HTI-56 in bronchoalveolar lavage fluid and serum were determined and compared between unilateral lung infection and bilateral lung infection.Results SP-D and HTI-56 levels were significantly higher in bronchoalveolar lavage fluid samples (P ＜ 0.05)compared with bronchoalveolar lavage fluid samples from uninfected lungs (P ＜ 0.05).However,the serum levels of SP-D and HTI-56 in children with unilateral lung infection and bilateral pulmonary infection were not significantly different (P ＞0.05).Conclusion High levels of SP-D and HTI-56 in bronchoalveolar lavage fluid samples from infected lungs may reflect damage to alveolar epithelial cells caused by mycoplasma pneumoniae.

The change of library space is driven by various factors, such as technology innovation, users demand and the changing competitive environments. The evolution processes of library space were thus clarified by retrie-ving CNKI, namely from computer and IT to Internet and wide application of information and communication tech-nology, from physical space to virtual space, from space function to information commons, learning, pioneering work and social intercourse, which can eventually lead to the intelligent, individual and ubiquitous library space.

The Many experiments show that pH affect the growth of romastigotes of L donovani. But the control tests with Acid - base scale have not been reported on the growth of promastigotes from different genesis. This paper reports that pH has different nfluence on several kinds of promastigotes from different genesis. We obseved that the growth of promastigotes of L. doncvani is inhibited when pH is 4.6 and 8.6.

Acupuncture is an important method to cure diseases in TCM.which has been extensively accepted.Acupuncture manipulation is a key point for good clinical curative effect because different manipulations can bring out different organic reactions.The author summarized clinical experience on acupuncture manipulations for acupuncturists to improve medical effects.

Objective To observe the health-related quality of life of children with recurrent respiratory tract infection (RRTI) simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine.Methods A total of 454 cases with RRTI were randomly divided into four groups,the control group (n =135) was used with placebo only,and the combined inoculation group (n =143) was simultaneously inoculated with pneumococcal vaccine combined with influenza vaccine,the pneumococcus vaccine group (n =95),influenza vaccine group (n =81).The PedsQLTM 4.0 score and clinical indicators were observed in each group before the inoculation and 14 months after the inoculation.Results There were no significant differences in the number of cases,gender,age,duration and socioeconomic status score in the four groups (P ＞ 0.05).The incidence of upper and lower respiratory tract infection,respiratory diseases caused by the frequency of fever,the number of days of antibiotic use and total cost of treatment in the vaccine group were significantly less than those of the control group (P ＜ 0.05).And the combined inoculation group was significantly better than the pneumococcus vaccine group and influenza vaccine group(P ＜ 0.0l).The PedsQLTM 4.0 score showed no significant differences among four groups (P ＞ 0.05) before the inoculation.Each dimension of the quality of life of the vaccine group significantly increased (P ＜ 0.05) while those of control group showed no significant difference (P ＞ 0.05).Conclusion Combination of inoculation of pneumococcal vaccine and influenza vaccine can effectively improve the health-related quality of life of RRTI children as well as the PedsQLTM 4.0 score,and it should be highly recommended clinically.

ObjectiveTo investigate the quality of life in patients with ankylosing spondylit2s(AS). Method86 patients were investigated by direct questioning using a uniform questionaire. ResultAll patients had different degree of stiffness on the lower back. 77.9% and 75.8% ofpatients ftequently had pain and fatigue respectively. 24. 4% of patients had sleeping disorder. 39.5% of patients had to change job or could notundertake normal work. 86% of patients had limitations in participating social activities. irritable feelings developed in 94. 1% of patients.91.8% of patients were not regularly treated before being admitted . ConclusionAll patients had few imitation in self- care and elementaryactivities in self - care. Most patients could perform their house hold tasks, although their severe symptoms have periodically flares. Many patientshad psychological problems.

Background:Acute hepatic failure( AHF)is a common pathophysiological process of end-stage liver disease with complex etiology,difficulty in diagnosis and high mortality rate. Aims:To investigate the protective effect of nicotinamide on AHF in mice. Methods:AHF model in mice was established by intraperitoneal injection with D-galactosamine 700 mg/kg and lipopolysaccharide 10 μg/kg. Fifty-four mice were divided into blank control group,nicotinamide control group, AHF model group and low,moderate,high dose(400,800,1 000 mg/kg)nicotinamide groups,levels of ALT,AST, TNF-α and IL-6 were determined,HE staining was used to examine hepatic histological injury,liver cell apoptosis was measured by TUNEL assay,and protein expression of Caspase-3 was detected by Western blotting. Another 40 mice were divided into AHF model group,saline group and low,moderate,high dose(400,800,1 000 mg/kg)nicotinamide groups,mortality rate was observed dynamically. Results:Compared with blank control group and nicotinamide control group,levels of ALT and AST were significantly increased(P<0. 05),infiltration of inflammatory cells and necrosis of cells and levels of TNF-α and IL-6 were significantly increased( P <0. 05 ),and apoptosis of liver cells and protein expression of Caspase-3 were significantly increased in AHF model group(P <0. 05). In groups pretreated with low, moderate and high dose nicotinamide,all the above-mentioned indices were significantly improved in a dose-dependent manner(P<0. 05). Survival rate in low,moderate,high dose nicotinamide groups was significantly higher than that in AHF model group(37. 5%,62. 5%,100% vs. 0%,P all <0. 05). Conclusions:Nicotinamide could protect mice from AHF via inhibiting inflammatory response and hepatocyte apoptosis,thereby increase the survival rate.