OBJECTIVE:To provide suggestions for the setting-up of the current pharmacovigilance(PV)system.METHODS:The characteristics of the setup of the PV system in both US and France were analyzed and the problems encountered in current monitoring system of adverse drug effects were pointed out.RESULTS & CONCLUSION:Both American and French PV systems have their own advantages and we should learn from it and draw useful experiences from them.In constructing PV system,China should make improvement in organization,communication,financial resource and information technology etc.

In order to have a better understanding of the relation between vertical dimension and occlusal force,a meter was made by means of straingauge.Five Japanese men were investi- gated for occlusal force at different vertical dimensions.The measurements showed that the maximal occlusal force of the posterior teeth occured at 8 to 15mm or the vertical dimension, the maximal occlusal forec of the anterior teeth occured at 13 to 18mm.This indicated that the occlusal force was closely related to the state of jaw closing muscle.

Animals ; Blood Glucose ; Cucurbita ; chemistry ; Diabetes Mellitus, Experimental ; drug therapy ; Hypoglycemic Agents ; pharmacology ; Lipids ; blood ; Oxidative Stress ; Polysaccharides ; pharmacology ; Rats

Objective To explore the effect of the different doses of oxytocin(OXT) on stress model aggressive behaviour in Wistar rats.Methods According to random number table,40 pregnant rats were divided into experimental stress groups (A, B, C) and control group(D) with 10 samples in each group.Before forced swimming test, rats in experimental groups (A, B, C)were given OXT via intraperitoneal injection with 0.3 mg/kg, 1.0 mg/kg,2.0 mg/kg;rats in group D were given equal volume of normal saline in the same way.At the 3rd day all rats were tested with maternal aggression,including mothers' following indices as total aggression times,biting times,pinning times,attack latency and duration of attack.Elevated plus maze (EPM) test was applied to analyze the behavioral changes.Results In terms of the duration of attack and attack latency,the indexes of group A and group D were significantly different from relevant data ((147.60±23.92) s and(79.70±9.88) s, P＜0.05), while other indexes had no difference(P＞0.05).The duration of attack and attack latency had a significant difference ((3.10±0.87) times, (13.60±5.14)times, (91.30±9.74)s and(167.20±30.02) s, P＜0.01) between group B and group D except total aggression times(P＞0.05).Group C and group D in given indexes had significant differences showing (6.40± 1.34) times, (15.10±4.35) times, (23.70±3.46) times, (49.80± 5.53) s and (215.60± 39.55) s (P＜0.01).Group A and group B in given indexes had significant differences (P＜ 0.05);and group B and group C had a significant difference (P＜0.01)except pinning times(P＞0.05).In EPM ,the open arm entry ratio and the open arm time ratio of both group A and group D were significantly different from respective percentage (0.47±0.13) and (0.13±0.05) (P＜0.01).The significant difference was found in group B and group D(P＜0.01);group A and group B had a statistical difference(P＜0.05);there was no difference in both groups in open arm time ratio(P＞0.05).Conclusion Oxytocin potentially mediates maternal aggression by attenuating stress, and improves the intimate bonding between mother and pups,which means dose dependency of OXT in this process.

Intrinsic or acquired chemo-resistance is the main reason for chemotherapy failure, and thus finding ways to reverse chemo-resistance has become an interesting topic for research. Studies have revealed that immunomodulatory molecules are involved in cancer chemo-resistance. Hence, interventions that target immunomodulatory molecules to reverse chemo-resistance have attracted a great deal of concern from domestic and foreign scholars. Immunomodulatory molecules, such as PD-L1, B7-H3, HMGB1, TRAIL, MyD88, and Cytokines (TNF-α, IFN-α, IL-6), have been proven to take part in regulating immune function and tumor drug-resistance characteristics, thereby providing new ideas to the reversal of tumor chemo-resistance. This artide reviews the progression of immuno-modulatory molecules with the change in cancer chemotherapy sensitivity to provide a theoretical basis for the application of new thera-peutic regimen of bio-chemotherapy.

Ethyl pyruvate ( EP) is a stable lipophilic ester derivative of pyruvate with many pharmacological actions confirmed by researches , the anti-tumor effects of EP has attracted the attention of many domestic and foreign scholars .EP exerts antitumor activi-ty through several ways , such as inhibiting proliferation , inducing apoptosis , inhibiting angiogenesis , blocking cell cycle .This paper briefly reviews the rencent findings of antitumor function of EP .

This study was aimed to investigate the seed protein of different forms ofTrichosanthis fructus from Shandong province. UV analyzer was used to analyze the seed protein content. PAGE fingerprint was drawn by Biosens Gel Imaging System software. The Jaccard coefficient was worked out by using NTSYS-pc software. A cluster dendrogram of different samples was established based on unweighted pair-group method with arithmetic means (UPGMA). The results showed that the content of different samples was obviously different. But there were many common bands in the fingerprints of PAGE. It was concluded that the content of seed protein cannot be used as the main index to evaluate the quality ofTrichosanthis fructus. The common bands in fingerprints of PAGE can be used to identifyTrichosanthis fructus.

miRNA is a kind of small,endogenous noncoding RNA which regulates gene expression in post-transcription level and is highly conserved and tissue-specificity,miRNA generally participates the regulation of many complicated vital process,such as cell growth,development and also plays an important role in the pathogenesis of many kinds of tumors,miR-34b is a newly discovered miRNA,which is regulated by p53,promoter methylation and so on.miR-34b can regulate cellular proliferation and apoptosis,and also involves in the generation and regulation of tumor,which suggests wide application prospect in therapy and prognosis of tumor.This review will focus on the progress of miR-34b and its relationship with tumor.

Objective　To study the effects of deliberated hypotension combined with acute simple hemodilution on blood loss,postoperative hemoglubin of the patients undergoing spinal side(back) protrude correction(SSP).Methods　Twenty four ASA grade Ⅰ to Ⅱ patients undergoing elective SSP were randomly divided into two groups:control group(n＝12) and hypotensive group(n＝12).The all patients received with general anesthesia.In the hypotensive group:acute simple hemodilution was accomplished with infusion of lactated Ringer's solution and Gelofusine of as three times as blood loss.Deliberated hypotensin was induced and maintained with 0.01% sodium nitroprusside 2～6μg/kg/min iv.Intraoperative blood loss,blood transfused volume during operation and postoperative hemoglobin were recorded and compared between both groups.Results　 Blood loss was about 51% lower in the deliberated hypotensive group than that in the control group at the end operation.The average volume of transfused blood during operation was(1200±140)ml in control group,blood transfusion was(400±128)ml in the hypotensive groups.Conclusion Deliberated hypotension combined with acute simple hemodilution can significantly decrease the intraoperative blood loss and the SSP operation can be better tolerated for the indicated patients.

BACKGROUND: Vitapex is an injectable root canal filling material. It possesses effects of antibiosis, analgesia, as well as promotes formation of alveolar bone, dentin and cementum, which had been widely used in apexification. However, it also has weakness of long induction time and need reduplicated subsequent visit.OBJECTIVE: To explore the therapeutic effect of mineral trioxide aggregate (MTA) and Vitapex paste on apexification.DESIGN, TIME AND SETTING: The contrast observation experiment was performed at the Department of Stomatology,Shenyang Children's Hospital from February 2006 to November 2008.PARTICIPANTS: A total of 42 patients with 49 teeth were included in this study, including 28 anterior maxilla and 21 premolars.The X-ray film showed that the root tip of teeth was immature.METHODS: The teeth were randomly divided into the experimental group (n=25) and control group (n=24), which was apexificated by MTA and Vitapex paste, respectively.MAIN OUTCOME MEASURES: The effective rate of two groups was compared at months 3, 6 and 12 after operation.RESULTS: All teeth were included in the final analysis. The effective rate of experimental group was greater than the control group at 3 months after operation, and the difference had significant (P < 0.05), while, the effective rate was similar in two groups at 6 and 12 months after operation (P > 0.05).CONCLUSION: Both MTA and Vitapex paste are ideal filling materials in apexfication. Nevertheless, MTA may be a substitute in apexfication for its short therapy duration and precisely therapeutic effect.