OBJECTIVE To explore the causes, predilection sites and treatment of nasal sinus mucoceles after hypophysectomy.METHODS The clinical data of 7 cases with nasal sinus mucoceles after hypophysectomy diagnosed and treated in our Department from Jan.1998 to Aug.2007 were retrospectively studied.RESULTS The mucoceles were located at ethmoid sinus in 2 cases,frontal sinus in 2 cases,frontal and ethmoid sinuses in 3 cases.All of the 7 cases underwent mucocelectomy under nasal endoscope or a combined endoscopic intranasal and extra-nasal approach.No recurrence was found after follow up for 1 to 3 years.CONCLUSION The causes of nasal sinus mucoceles after hypophysectomy are the change of the anatomic structure of nasal cavity after surgery.The stenosis,adhesion of middle nasal meatus or obstruction of the sinus ostium are found in all the patients.Intranasal endoscopic surgery or combined with extra-nasal approach is the first choice for nasal sinus mucoceles.

Adolescent ; Adult ; Barotrauma ; complications ; Female ; Humans ; Male ; Middle Aged ; Occupational Diseases ; etiology ; therapy ; Sinusitis ; etiology ; therapy ; Young Adult

Objective:To observe the clinical efficacy of Pingxiao capsules in the treatment of benign thyroid nodules. Methods:Totally 240 patients with benign thyroid nodules were randomly divided into the treatment group and the control group with 120 ones in each. The control group received levothyroxine at low dose, the treatment group received Pingxiao capsules, and the treatment course was 3 months. The type B ultrasonic inspection and lab inspection ( for thyroid hormones and blood lipid) were carried out, the cura-tive effect was compared and the adverse reactions were recorded as well. Results:Three patients in the treatment group and five ones in the control group were lost during the follow-up. After the treatment, the max diameter of thyroid nodule and the thyroid volume de-creased in both groups (P<0. 05), and those in the treatment group were smaller than those in the control group (P<0. 05). The levels of TSH and TC in the control group decreased after the treatment, which were significantly lower than those in the treatment group (P<0. 05). The total effective rate in the treatment group was higher than that in the control group, and the incidence of ad-verse reactions was lower than that in the control group, and both had significant differences between the groups (P<0. 05). Conclu-sion:Pingxiao capsules are effective and safe in the treatment of benign thyroid nodules.

Objective To discuss the causes and management of the complications of the transurethral electrovaporization of prostate(TVP) to improve the effect.Methods All 820 cases took TVP.3～6 months follow-up was taken to investigate the complications and their disposal.Results No patient died,6 cases had massive haemorrhage during operation,6 cases had presymptom of TUR syndrome,5 cases had perforation of juncture of bladder and prostate,6 cases had acute pulmonary thromboembolism(PTE) after TVP,32 cases had spasm of bladder,18 cases had urethral stricture,3 caess had postoperative bleed,11 cases had retrograde ejaculation,13 cases had temporary incontinence,24 cases had infection of urinary tract.Conclusion Pre-operational precautions are essential,the complications of TVP may be decreased by accurate operation and reliable management of infection.

Lifelong blood cell production is achieved by the capacity of hematopoietic stem cell(HSC) to differentiate and self-renew.A growing body of evidence suggest that DNA damage induced HSC senescence may be the principal mechanism of aging and HSC exhaustion in response to the stress exposure.Understanding the mechanisms of HSC senescence will help to find new therapeutics that can ameliorate HSC injury induced by chemo-and radiotherapy,elucidate the molecular mechanisms whereby leukemia/cancer stem cell arise and evade cancer therapy by escaping senescence,and identify the novel molecular targets for intervention.

Objective To study the mechanism of rat blood pressure lowered by SO2 and SO2 derivatives.Methods 6-Keto-PGF1? and TXB2 were determined by radioimmunoassay in the plasma and aorta tissue of rats.Results The 6-Keto increased significantly in the isolated aortic rings in all exposure groups except 8 mmol/L group.No change of TXB2 was observed in the rings in all exposure groups.Meanwhile,6-Keto/TXB2 ratios increased significantly at 2 mmol/L and 4 mmol/L.Compared with the control group,6-Keto level decreased significantly in the plasma of the rats exposed to SO2 at 14 mg/m3,28mg/m3 and 56 mg/m3,but the level of TXB2 increased significantly.6-Keto/TXB2 ratios decreased gradually with the increase of SO2 concentration.Conclusion PGI2 and TXA2 are possibly changed by SO2 and SO2 derivatives,which regulates partly rat blood pressure.

Objective:To investigate effectiveness of exposure and ritual prevention of patients with obsession-compul-sive disorder(OCD),so as to provide references for professionals in clinical psychology.Methods:One female patient with severe OCD received 3 weeks intensive exposure and ritual prevention treatment.In order to investigate the effectiveness,she completed Symptom Check List 90 and Yale Brown Obsessive Compulsive Scale(SCL-90 and YBOCS) at pre-treat-ment,mid-treatment and post-treatment.Results:After treatment,the patient's scores of questionnaires reduced,such as score on YBOCS reduced from 38 to 9.She reported that her washing time reduced obviously and her own measure of dis-tress index reduced.Conclusion:Exposure and ritual prevention could treat the patient with OCD effectively.Her distress reduced and life function was improved.

The status of bioelectrical impedance measurement especially the multifrequency segmental bioelectrical impedance measurement of liver diseases is introduced.The multifrequency segmental bioelectrical impedance can well rule out the impact from the change of body weight caused by edema and ascites,and can evaluate the volume of ascites.Compared with single frequency bioelectrical impedance,the multi frequency bioelectrical impedance measurements probably display good prospect.It helps to produce objective judgement on nutrition status and energy metabolism for patients with liver diseases.The effect,however,needs further clinical research.

P53 gene is one of the most widely studied genes in cancer. As a tumor suppressor gene, wild-type P53 can effectively inhibit the occurrence and development of tumors, but P53 mutations are found in about 50% of cancer patients[1]. In recent years, the mechanism of oncogenesis caused by the imbalance of P53 signaling pathway has become a focus of academic research. With the development of biotechnology, long non-coding RNA(lncRNA)has become a new hotspot in the research field. A large number of researches have shown that the interaction between some lncRNA and P53 can affect relevant signaling pathways in tumor development, such as P21(long intergenic noncoding RNA-P21, linc RNAP21)and loc285194, resulting in abnormal cell proliferation. This paper reviews the latest research progress in lncRNA which is closely related to P53 in the process of cancer occurrence, so as to provide a reference for further understanding of the mechanism of cancer.