Objective] To study the transmission of the Ishinpo versions ,understand the prevailing version of Ishinpo. [Method] With the research methods of the Chinese traditional history and philology,collect and sort historical cited references of the Ishinpo, by paying attention to three main emendation in the transmission history of Ishinpo. [Result] Ishinpo of Nakarai is the golden version for document research. The prevailing Ansei Ishinpo version of contemporary China is based on Nakarai version,which consists of twenty seven scrolls of Hei era and three scrolls of Edo Era. Ishinpo Versions have been divided into Emperor Nakarai versions,Uji versions and Family tradition versions. There are big differences in utilization and completeness of the three version system. The Emperor Nakarai versions are relatively good, of which the Nakarai version preserves best. The Uji versions are widespread, of which the RenHe Temple version is better preserved but lacuna. There are lots of lacunas in the family tradition versions, owing to circulateed copies. [Conclusion] In the three main emendation, of Ishinpo, mostly, the Nakarai version is the source edition, the Uji version is primary edition, and the family tradition version is the secondary edition. The paper, which is useful in the transmission of the Ishinpo and thus historical process of medical exchange between China and Japan, has established the system of Ishinpo versions, defined the golden version and the prevailing version.

The ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor,which can regulate the secretion of GH,stimulate the appetite,adjust the energy metabolism,and improve the cardiovascular function.Children with congenital heart disease (CHD) usually suffered from malnutrition and growth retardation,which were connected with insufficiency of energy intake,poor absorption,and increase of nutritional requirement,anatomy and the changes of hemodynamics.Many infants with CHD gradually present ventricular dysfunction and growth restriction in their early childhood,which consequently lead to severe complications.Ghrelin is valuable in the early detection of potential CHD,plays an important role in improving the state of malnutrition and protecting the cardiac function,and provides an important reference to explore the new drug therapy for CHD.This review summarized the effects and significances of ghrelin on growth and cardiac function in infants with CHD.

1 5 cases,5 males and 1 0 females,aged 1 6-26 years,with ClassⅡdivision maxillary mild to moderate protrusion were includ-ed.Damon III appliance was used to arrange the upper and lower dentition.Stainless steel micro-screw implants were implanted in zygomatic crest to provide the best bone anchorage,stainless steel rectangular wire was used for maxillary complete dentition continuous ligation and maxillary teeth distal movement.X-ray cephalometry study showed that U1-NA(°)reduced by 2.51 ±1 .52(P<0.01 ),U1-NA(mm)re-duced by 4.56 ±1 .25,UL-EP(mm)reduced by 2.21 ±1 .83,U6E-PTV(mm)reduced by 2.93 ±1 .1 7,U6A-PTV(mm)reduced by 1 .56 ±0.95,SNA(°)and the mandibular parameters were not significantly changed(P>0.05),centric jaw relation of bilateral molar was obtained.

Objective To investigate the correlation between the serum levels of homocysteine (Hcy) ,folate acid (FA) and vita‐min B12 (VitB12 ) with cerebral infarction .Methods The enzymatic cycling method and chemiluminescence immunoassay were used to detect the serum Hcy ,FA and Vit B12 levels in 60 patients with cerebral infarction ,and then the detection results were compared the results of 40 people undergoing physical examination in the same period .Results The serum Hcy level in the cerebral infarction group was (23 .16 ± 8 .17)μmol/L ,which was significantly higher than (8 .09 ± 2 .45)μmol/L in the control group(P<0 .01) ,and the serum FA and Vit B12 levels in the cerebral infarction group were (6 .12 ± 2 .19) ng/mL and (323 .92 ± 133 .79)μmol/L ,which were in the control group lower than (10 .57 ± 5 .70) ng/mL and (530 .85 ± 168 .56)μmol/L in the control group (P<0 .01) .The serum Hcy level in the cerebral infarction group showed the negative correlation with FA and VitB 12 levels ( r1 = - 0 .444 , r2 = -0 .535 ,P<0 .05) .Conclusion High hyperhomocysteinemia is an independent risk factor of cerebral infarction and is related to the decrease of FA and VitB12 .

Cone-bine CT(CBCT)images of 2 130 maxillary third molars were divided into 3 groups according to the impaction position. The relationship between the floor of maxillary sinus and the roots of maxillary third molar was analyzed and compared.In low,median and high impaction groups the probability of the root tip of maxillary third molar higher than the floor of maxillary sinus was 4.5%,10.3% and 14.6% respectively.

This paper reports a child with acute schistosomiasis,the routine X-ray of chest indicates the case is a typical pulmonary schistosomiasis.

Objective To compare the expressions of basic fibroblast growth factor (bFGF) in retinas of rd mouse (the experiments) and C57BL mouse (the controis) of five different postnatal ages,analyze the similarities and differences of bFGF expressions,and conclude the role of bFGF during the key period that retinas developed or degenerated,Methods Eight rd mice and eight C57BL mice of postnatal 0 week,1 week,2 weeks,3 weeks,4 weeks (PN 0,1,2,3,4 W) were chosen stochastically and executed immediately,their eyeballs were excavated and made into the retinal slices,then the bFGF contents in the retinas were analyzed by immunohistochemical method,photomicroscope and semi-quantitative analysis.Results Change characteristic of the curve of bFGF contents in retina of rd mice was similar to that of C57BL mice.Both curves began to fall after born,which reached each low level at PN-1W and then rose until reaching each peak at PN-2W,at which ten layer structures of retinas in both groups were formed.Then both curves began the second fall till PN-4W.During the last two weeks,retinas of C57BL mice degenerated rapidly while retinas of rd mice continued to mature.For all the five postnatal weeks,the bFGF contents in retinas of rd mice were lower than those of C57BL mice evidently.All statistical analysis of the difference have made sense distinctly (P ＜ 0.01).Couclusion bFGF may play a protective role in the developing to maturation and sustaining of retinal structure,and the higher expression of bFGF content may prevent retinal degeneration in some extent.

Nucleated red blood cells (nRBCs) are immature red blood cells, which are rarely in circulating blood in elder children, but often present in neonatal blood. The clinical significance in neonates is unclear. Numerous studies have shown that many kinds of acute and chronic stimuli can lead to an increase in the number of nRBCs in circulating blood. This article reviews various pathological processes related to the production and release of nRBCs, and emphasizes the effects of acute and chronic hypoxia and immune regulation on it.

Objective To research the tissue structure changes of vessels wall in the patients with liver cirrhotic portal hypertension and to investigate the role of inducible nitric oxide synthase (iNOS) in development process of liver cirrhosis.Methods The left portal vein,left hepatic artery and left hepatic vein (n=27) were collected from the patients with liver transplantation as the case group and the corresponding vessels of traumatic hepatectomy were collected as control group (n=15).HE staining and Masson staining were performed respectively.The hepatic arteries were stained with elastic fibers and immunized with anti-human iNOS polyclonal antibody.Results Compared with the control group,the portal vein intima and tunica media in the case group were thickened,the smooth muscle cells of tunica media were hyperplasia and hypertrophy,partial smooth muscle cells protruded into the intima;the irregular proliferation of hepatic arterial intima,arterial luminal stenosis,internal elastic membrane flatten,and even fracture,the tunica media smooth muscle hyperplasia to the intima were also observed;no obvious structural changes were observed in the hepatic vein wall.The higher expression of iNOS was found in the cytoplasm of hepatic artery smooth muscle cells (P<0.01).Conclusion The walls of liver artery and portal vein in the patients with liver cirrhosis would secondarily develop the tissue structure reconstruction,which is the results of human body′s own compensatory mechanism,the higher expression of iNOS accelerats the occurrence and development of the tissue structure reconstruction.

Objective:The present research aimed to explore the involvement of ERK signaling pathway in apoptosis of hepatic carcinoma induced by decitabine combined sodium valproate.Methods: HepG2 cell line was incubated with decitabine combined sodium valproate and the inhibition rate was detected by MTT method.The apoptotic related protein and ERK signal pathway proteins were assayed by Real-time PCR or Western blot.Results: The HepG2 cell line was inhibited greatly by decitabine combined sodium valproate medication with an increased expression of Caspase3,Caspase9 and Bax (P<0.05).The expression of Ras,Raf,MEK and ERK1/2 was increased dramatically after incubation with decitabine combined sodium valproate when compared with control group ( P<0.05).Conclusion:Decitabine combined sodium valproate exert a significant inhibition on the proliferation of HepG2 cell line by nor-malizing the abnormal MEK/ERK signaling pathway.