1.Hematopoietic Stem Cell Transplantation after Posttransplant Lymphoproliferative Disorder.
Min Joo KIM ; Inho KIM ; Hyun Mi BAE ; Kyungsuk SEO ; Namjun PARK ; Sung Soo YOON ; Seonyang PARK ; Byoung Kook KIM
Journal of Korean Medical Science 2010;25(5):781-784
A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed posttransplant lymphoproliferative disorder (PTLD). Immunosuppression reduction was attempted, but it produced no therapeutic effect. Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD.
Adolescent
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Female
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Hematopoietic Stem Cell Transplantation/*methods
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Humans
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Liver Transplantation/*adverse effects
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Lymphoproliferative Disorders/*etiology/*surgery
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Treatment Outcome