Due to the coronavirus disease 2019 (COVID-19) pandemic, people's physical activity has declined by 35% because their time spent at home has increased. Decreased physical activity can increase both the number of people with type 2 diabetes annually by more than 11.1 million and the number of deaths by more than 1.7 million. Thus, exercise is important during the COVID-19 pandemic, especially in relation to diabetes. If a person with the COVID-19 virus lacks exercise, the risk of hospitalization is increased by 2.2 times and the risk of death by 2.5 times. In the context of COVID-19, the purpose of home training for patients with diabetes mellitus is to reduce body fat percentage, increase muscle function and mass, and improve insulin resistance. The recommended home training program is a circuit-based exercise regime that combines aerobic exercise and strength exercise. In addition, muscle stretching exercises are recommended for home training programs to increase muscle function.

Liver cancer is prevalent worldwide and associated with a high mortality rate. Therefore, developing novel drugs derived from natural products to reduce the side effects of chemotherapy is urgently needed. In this study, the inhibitory effect of Dendropanax morbifera Leveille extract (DME) on growth of hepatocellular carcinoma (HCC) cells and its underlying mechanisms were investigated.DME suppressed the growth, migration, and invasion of SK-Hep1 human HCC cells. It also reduced the expression of the G0/G1 phase regulator proteins cyclin-dependent kinase (CDK) 4, cyclin D, CDK2, and cyclin E, thereby inducing G0/G1 arrest. Moreover, DME treatment reduced the expression of antiapoptotic proteins, including caspase-9, caspase-3, PARP, and Bcl-2 and increased the expression of the proapoptotic protein, Bax. DME also increased reactive oxygen species production and reduced the cellular uptake of rhodamine 123. DME treatment increased the levels of p-p38 and p-FOXO3a in a dose-dependent manner and decreased those of p-PI3K, p-AKT, p-mTOR, and p-p70 in SK-Hep1 cells. In addition, combined treatment with DME and LY294002, an AKT inhibitor, significantly reduced p-AKT levels. In summary, these results show that the PI3K/AKT/mTOR signaling pathway is involved in DME-mediated inhibition of proliferation, migration, and invasiveness, and induction of apoptosis of HCC cells.

Purpose: This is a descriptive correlation study to confirm the effect of stress and anxiety caused by COVID-19 on the quality of life of small business owners in an area under environment of COVID-19. Methods: The participants were 150 small business owners in an area. The collected data were analyzed by descriptive statistics, an independent t-test, a one-way ANOVA, Pearson's correlation coefficients, and multiple regression with the SPSS 25.0 Program. Results: The stress of small business owners averaged 3.67±0.65 out of 4 points, anxiety of COVID-19 was 2.65±0.52, and quality of life was 75.61±20.26 out of 130 points. The quality of life showed a significant negative correlation with ‘fear of infection’ (r=-.42, p<.001), ‘difficulties caused by social distancing’ (r=-.49, p<.001) in the stress subdomain, and anxiety (r=-.61, p<.001). On the other hand, stress, ‘fear of infection’ (r=.50, p<.001), ‘difficulties caused by social distancing’ (r=.60 p<.001), ‘anger against others’ (r=.35, p<.001) and anxiety showed positive correlation. Factors affecting the quality of life of the subjects were ‘fear of infection’ in the stress subdomain (β=-.23, p=.003), anxiety (β=-.45, p<.001), and residential area (J zone) (β=-.16, p=.030). These factors explained 47.0% of the variance. Conclusion In order to enhance the quality of life of small business owners in an area, it is required to reduce stress and anxiety. In addition, it is necessary to prepare an intervention program that can reduce stress and anxiety of small business owners.

Purpose: This study investigated the influence of nursing practice readiness and, resilience on the nursing performance of new nurses. Methods: Participants were 234 new nurses with 6-24 months of working experience at the wards in university and general hospitals in the B area and C areas. The collected data were analyzed using SPSS/Win 24.0, and frequency percentage, mean, and standard deviation were calculated, Mann-Whitney U test, Kruskal-Wallis test, analysis of variance, Pearson's correlation coefficients, and multiple regression analyses were performed, and the variable selection method was set as stepwise. Results: Nursing performance significantly differed by weekly job-related education (Z=10.01, p=.007) and salary satisfaction (Z=13.04, p=.001). The nursing performance of new nurses was positively correlated with nursing practice (r=.70, p<.001) and resilience (r=.51, p<.001). The significant predictors of nursing performance were nursing practice readiness (β=.61, p<.001), resilience (β=.16, p=.003), and job training hours (β=.11, p=.02). The explanatory power of these factors was 52.0% of the variance. Conclusion To enhance the nursing performance of new nurses, it is necessary to improve nursing practice readiness, provide job training, and strengthen resilience. In addition, it is necessary to support programs at the institutional level for nursing performance.

Purpose: This study aimed to examine the processes of adaptation lung cancer patients undergo by examining their social interactions with medical staff, families, and other patients during hospitalization. Methods: Data were collected from February 2017 to January 2018 for a qualitative research study based on in-depth interviews with 10 participants who were inpatients at a cancer treatment hospital. Data were analyzed using the grounded theory of Corbin and Strauss. Results: Through comparative analysis, we identified the central phenomenon of the study was, ‘living in a body that is not related to one's own will.’ The causal conditions were, ‘hit by a bolt out of the blue’ and ‘a disease that I do not want to inform others of.’ The contextual conditions were, ‘an encounter with reality’ and ‘breaking down the wall of fear.’ The intervention conditions included, ‘finding comfort in adversity,’ ‘a loaf of bread is better than the song of many birds,’ and ‘the communion of the same situation.’ Action/interaction strategies included ‘sharing information,’ ‘a word of encouragement,’ and ‘accepting the wave of change.’ Finally, the perceived consequences were ‘life redesign’ and ‘a life journey with limited time.’ Conclusion This study describes the processes underlying how patients find meaning in their lives after a diagnosis of lung cancer. Based on their experiences, it is necessary to offer nursing interventions including admission rooms, equipment, and instruments to meet the unique needs of patients. The findings indicate that inpatient treatment for lung cancer needs more meaningful and effective management.

BACKGROUND: Myricetin has been shown to possess potential antiangiogenic effects in endothelial cells. However, the underlying mechanisms are not fully understood. Therefore, we evaluated its antiangiogenic effects in human umbilical vascular endothelial cells (HUVECs). METHODS: HUVECs were cultured in endothelial cell growth medium-2 to induce proliferation and angiogenesis and treated with different doses of myricetin (0.25, 0.5, and 1 μM) for 24 hours. Cell proliferation was analyzed by the MTT and lactate dehydrogenase release assays; angiogenesis was determined by the tube formation assay. In addition, cell signaling pathways related to angiogenesis were investigated by Western blotting. RESULTS: Myricetin induced apoptosis and procaspase-3 cleavage though the induction of reactive oxygen species (ROS). It significantly inhibited cell migration, tube formation, and PI3K/Akt/mTOR signaling in HUVECs. CONCLUSIONS: Myricetin exerts antiangiogenic effects by inducing ROS-mediated apoptosis and inhibiting PI3K/Akt/mTOR signaling in HUVECs.
Apoptosis* ; Blotting, Western ; Caspase 3 ; Cell Movement ; Cell Proliferation ; Endothelial Cells* ; Humans ; L-Lactate Dehydrogenase ; Reactive Oxygen Species

PURPOSE: This study was done to construct and test a structural model to explain health risk behavior of late adolescents. METHODS: Data for this study were secondary data from the 2010 Korea Adolescent Health Survey based and 3,675 high school students who participated. Data were analyzed using SPSS 18.0 and AMOS 19.0 programs. RESULTS: After 7 lines were removed, fitness statistics for the hypothetical model were appropriate (chi2=559.13, p<.001, GFI=.98, SRMR=.03, RMSEA=.04, NFI=.88, IFI=.90, CFI=.90, TLI=.86, AIC=671.13). The result showed that drinking-smoking is directly affected by 5 variables (32.5%), obesity is directly affected by 2 variables (0.7%), lack of physical activity is directly affected by 5 variables (22.2%), skipping of breakfast is directly affected by 3 variables (11.9%), improper sleep is directly affected by 3 variables (7.5%), and psychological adaptation is directly affected by 4 variables (26.8%). CONCLUSION: The results of this study, indicate that late adolescents' health risk behavior is affected by many factors with complicate correlations suggesting further study compare youth health risk behaviors in a variety of environments.
Adaptation, Psychological ; Adolescent ; Alcohol Drinking ; Body Mass Index ; Feeding Behavior ; Female ; *Health Behavior ; Health Surveys ; Humans ; Male ; *Models, Theoretical ; *Psychology, Adolescent ; Questionnaires ; Republic of Korea ; Risk-Taking ; Self Efficacy ; Smoking

PURPOSE: The purposes of this study were to investigate eating behavior of university students through social commerce and to analyze factors affecting university students' attitude regarding social commerce. METHODS: Questionnaires were distributed to 445 university students in Changwon, Korea from March 28 to April 28, 2013. A total of 339 questionnaires were used for the final analysis, which excluded improperly-completed questionnaires. RESULTS: The major factor considered for eating behavior through social commerce was price (37.2%). Purchasing experiences of foodservice products according to types of foodservice were 64.9% for coffee shop, 59.3% for fast food restaurant, 53.4% for family restaurant, 46.0% for specialty restaurant, 35.7% for pizza restaurant, 35.4% for buffet, and 31.9% for bakery. Factors affecting satisfaction with social commerce for purchasing foodservice products were 'service quality of foodservice company', 'communication of social commerce', and 'discount rate of social commerce'. Factors affecting repurchasing intention of foodservice products through social commerce were 'service quality of foodservice company', 'site design of social commerce', and 'discount rate of social commerce'. CONCLUSION: In order to increase satisfaction with social commerce, 'service quality of foodservice company', 'communication of social commerce', and 'discount rate of social commerce' should be increased. And, to increase repurchasing intention of social commerce, 'service quality of foodservice company', 'site design of social commerce', and 'discount rate of social commerce' should be increased. In addition, two factors 'service quality of foodservice' and 'discount rate of social commerce' were found to have an effect on satisfaction and repurchasing intention of social commerce. For development of social commerce and foodservice industry, cooperative relationship between social commerce and foodservice industry is needed, and a reasonable price strategy should be established. The university students considered price as a major factor of eating behaviors and did not consider menu and taste as a major factor. From a longer perspective, such an eating behavior would have an effect on university students' dietary life and it would cause nutrition and health problems for university students. Thus, it implied that further studies from the perspectives of nutrition and health regarding eating behavior through social commerce service should be conducted.
Coffee ; Commerce* ; Fast Foods ; Feeding Behavior* ; Gyeongsangnam-do ; Humans ; Intention ; Korea ; Surveys and Questionnaires ; Restaurants

The purpose of this study was to analyze the influence of the consumer-brand relationship quality on the customer satisfaction in the family restaurant. The questionnaires were distributed to 320 students in the K University located in Masan, who were sampled by convenience-sampling method. The surveys were conducted from November 10 to 24, 2005. The 287 questionnaires responded, and 15 unusable questionnaires were excluded, then 272 were used for the final analysis (response rate: 85.0%). For the statistical analysis, SPSS (12.0) was used to conduct the descriptive analysis, factor analysis, reliability analysis, Pearson correlation and multiple regression analysis. The result of this study showed that 2 constructs (trust and intimacy) of consumer-brand relationship quality have significant positive effects on the customer satisfaction in the family restaurant (p < .001). It meant that as consumer-brand relationship quality becomes stronger, the customer satisfaction becomes greater. As a conclusion, the foodservice manager in the family restaurant should focus on the marketing strategy to strengthen the quality of consumer-brand relationship in order to increase the satisfaction of customers.
Humans ; Marketing ; Restaurants*

PURPOSE: Personal protective equipment (PPE) is critical to protect healthcare workers from pandemic outbreaks. This study was designed to identify nurses' knowledge, attitude and perceptions on PPE. METHODS: Data were collected from 154 nurses working at a tertiary general hospital, where positively diagnosed and suspected patients were accepted and admitted during the Middle East Respiratory Syndrome Coronavirus outbreak in 2015. The PPE tool consists of 20 items for knowledge, and 5 each for attitudes and perceptions. RESULTS: Overall, knowledge for PPE was higher thanmoderate (76.95/100), but there was a lack for items related to powered air purifying respirator (PAPR). For attitudes, willingness to work in pandemic outbreaks was the most positive (4.04/5.00). Goggles and PAPR were perceived as themost uncomfortable barriers to work. There was no correlation between knowledge, attitude and perceptions, despite a strong positive correlation between attitude and perceptions. PPE training was identified as a factor to improve knowledge and attitudes on PPE. CONCLUSION: To respond to pandemic influenza, nurses need to expand their knowledge on PPE up to Level C, and be updated through regular training. Study findings suggest that repetitive studies targeting nurses and other healthcare workers at various hospital settings are necessary.
Coronavirus Infections* ; Delivery of Health Care ; Disease Outbreaks ; Eye Protective Devices ; Hospitals, General ; Humans ; Influenza, Human ; Middle East Respiratory Syndrome Coronavirus* ; Middle East* ; Pandemics ; Personal Protective Equipment* ; Ventilators, Mechanical