No abstract available.
Humans ; Parkinson Disease*

A stomach cancer patient is reported, who presented with asterixis and dysarthria, after the administration of 5-fluorouracil derivatives, and progressed to a state of arnnesia and disorientation. At first impression was metastatic brain tumor however7 the result of a cerebrospinal fluid cytology for malignancy was negative, and magnetic resonance imaging study(MRI) revealed diffuse hyperintense lesion of the white matter, indicative of leukoencephalopathy. Upon discontinuing the drugs, patient recovered significantly.lly predominant muscle weakness from distal myopathy with rimmed vacuole formation While we present a young female.
Brain Neoplasms ; Cerebrospinal Fluid ; Distal Myopathies ; Dysarthria ; Dyskinesias ; Female ; Fluorouracil* ; Humans ; Leukoencephalopathies* ; Magnetic Resonance Imaging ; Muscle Weakness ; Stomach Neoplasms ; Vacuoles

Tinea capitis is a fungal infection of the scalp and hair. It is very common in children and unusual in adults. We evaluated the clinical and mycologic aspects of tinea capitis in 6 adult patients registered in Kyunghee University Hospital from January 2003 to December 2003. The isolated dermatophytic flora of the patients consisted of Trichophyton rubrum (83%) and Microsporum canis (17%). When tinea capitis occurs in adults the clinical features may be atypical and this may delay the diagnosis. The necessity for heightened clinical suspicion and diagnostic tenacity in the evaluation of adults with scalp dermatitis and/or alopecia for possible tinea capitis is underscored.
Adult* ; Alopecia ; Child ; Dermatitis ; Diagnosis ; Hair ; Humans ; Microsporum ; Scalp ; Tinea Capitis* ; Tinea* ; Trichophyton

Purpose: The purpose of this study was to identify the possible correlations of ‘satisfaction with clinical practice (SA)’ with ‘clinical learning environment (EN)’ and ‘clinical practice stress (ST).’ We searched for the mediating effect of ‘clinical practice stress’ on ‘satisfaction with clinical practice’ when the clinical learning environment influences ‘satisfaction with clinical practice.’ Methods: This research investigated 208 medical and nursing students attending the school of medicine and nursing in Korea. The total number of nursing students was 135 (64.9%); 73 medical students participated (35.1%). We used the Korean-Undergraduate Clinical Education Environment in 24 questions for EN, ST scale in 24 questions, and SA scale in 10 questions. We performed measurement structural equation model analysis to identify a path of the model. Results: Medical students had significantly higher levels of ST. EN had a significant negative correlation with ST and a significant positive correlation with SA. The ST had a significant negative correlation with SA. The results of the goodness of fit index have fulfilled the criteria of goodness of fit. There was a significant mediating effect of ST on SA when EN influences SA. Conclusion The clinical learning environment affected satisfaction with the clinical practice directly or indirectly mediated by clinical practice stress. Therefore, educational institutes should try to increase satisfaction with clinical practice by continuously monitoring and improving the clinical learning environment in addition to taking measures for decreasing the clinical practice stress.

Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can self-renew and can differentiate into many cell types, offering a potentially unlimited source of cells for targeted differentiation into somatic effector cells. Hence, iPSCs are likely to be invaluable for therapeutic applications and disease-related research. In this review, we summarize the recent progress of iPSC generation that has been made with an emphasis on both basic and clinical applications including disease modeling, drug toxicity screening/drug discovery and cell replacement therapy.
Drug Design ; Genomics ; Humans ; Induced Pluripotent Stem Cells ; Proteomics ; Regenerative Medicine ; Stem Cells

Kerion celsi is a highly inflammatory, supprative fungal infection of the scalp caused mainly by zoophilic dermatophytes transmitted from animals to man. We report a case of kerion celsi caused by Trichophyton (T.) mentagrophytes in 9 year-old male, who showed 10 x 9 cm and 2 x 1 cm sized, markedly inflammatory, boggy masses on the scalp and erythematous scaly patch on the philtrum. Cultures from a scalp lesion of the patient on Sabouraud glucose agar showed T. mentagrophytes. Treatment was done systemically with steroid and antifungal agents.
Agar ; Animals ; Antifungal Agents ; Arthrodermataceae ; Child ; Glucose ; Humans ; Lip ; Male ; Scalp ; Tinea Capitis* ; Trichophyton*

The authors reported and reviewed 7 cases of seizures among 53 chronic alcoholics who had been hospitalized in Kyung Hee University Hospital from Jan. 1, 1979 to Mar. 31, 1983. Case 1 was considered to be alcohol withdrawal seizure (so called "rum fit") in terms of it's clinical and laboratory findings. And other 6 cases, which had no past history of epilepsy and had been drinking alcoholic beverages for 9.6 years on the average before the appearances of seizures, were considered to belong to alcoholinduced seizures.
Alcohol Withdrawal Seizures ; Alcoholic Beverages ; Alcoholics* ; Drinking ; Epilepsy ; Humans ; Seizures*

Although thrombolytic therapy is one of the most effective therapeutic option for acute ischemic stroke, hemorrhagic complication still remains major concern about its application. A patient with hemoperitoneum, who previously underwent thrombolytic therapy(intraarterial urokinase infusion, IAUK) for acute ischemic stroke was treated successfully with emergency transarterial embolization for rupture of hepatocellular carcinoma. We present a rare case of rupture of hepatocellular carcinoma after intraarterial urokinase infusion for acute ischemic stroke with brief review of the literature.
Carcinoma, Hepatocellular ; Emergencies ; Hemoperitoneum* ; Humans ; Rupture ; Stroke* ; Thrombolytic Therapy ; Urokinase-Type Plasminogen Activator*

Only a few reports have focused on ocular motor paralysis in herpes zoster ophthalmicus. We report a case of ocular motor paralysis resulting from herpes zoster. The patient, an 80-yr-old woman, presented with grouped vesicles, papules, and crusting in the left temporal area and scalp, with diplopia, impaired gaze, and severe pain. Her cerebrospinal fluid analysis was positive for varicellar zoster virus IgM. Magnetic resonance imaging was performed to rule out other diseases causing diplopia; there were no specific findings other than old infarctions in the pons and basal ganglia. Therefore, she was diagnosed of abducens nerve palsy caused by herpes zoster ophthalmicus. After 5 days of systemic antiviral therapy, the skin lesions improved markedly, and the paralysis was cleared 7 weeks later without extra treatment.
Abducens Nerve Diseases/*complications/*diagnosis/therapy ; Acyclovir/*therapeutic use ; Aged, 80 and over ; Antiviral Agents/therapeutic use ; Female ; Herpes Zoster/*complications/*diagnosis/therapy ; Herpes Zoster Ophthalmicus/complications/diagnosis ; Humans ; Skin Diseases, Viral/complications/diagnosis/therapy ; Treatment Outcome

In light of the need for a tool to evaluate the clinical practice education environment as perceived by medical and nursing students, this study is was conducted to develop and validate the Korean version of the Undergraduate Clinical Education Environment Measure (K-UCEEM) as a measurement tool for managing the clinical practice education climate and quality of education. For validation, the UCEEM consisting of 25 items developed by Pia Strand in 2013 was adapted according to standard translation procedures. The K-UCEEM questionnaire was administered to 73 medical students and 135 nursing students who participated in clinical practice at one medical institution. Exploratory factor analysis and confirmatory factor analysis were conducted to confirm the validity of the instrument’s structure. In order to determine referential validity, the relationships among stresses in clinical practice were examined, and differences in factor scores were compared by gender and college. It was confirmed that the scale of 24 items and five factors showed a moderate model fitness index. The reliability of the factors ranged from 0.786 to 0.867. In addition, all five factors were found to have negative correlations with the clinical practice stress sub-factor, and there were statistically significant differences by gender and college. Through this study, the validity and reliability of the K-UCEEM were verified. In the future, it is expected that further verification of the scale, as well as evaluation and improvement of the clinical practice education environment based on this scale, will occur.