No abstract available.

No abstract available.

Herpes simplex encephalitis (HSE) is rare, serious sporadic encephalitis associated with high mortality in untreated cases. Although cognitive impairment with fever could be the clue of diagnosis, various symptoms can make it difficult to be diagnosed. Dizziness is one of the most frequent symptoms ENT doctors can encounter. Authors experienced the HSE patient suffered rotatory sense of dizziness as a primary symptom and treated the patient successfully without major complication. We reported our experience and findings of vestibular function test of patient. It could be helpful to other ENT doctors who encounter similar patients.
Dizziness ; Encephalitis ; Encephalitis, Herpes Simplex ; Fever ; Herpes Simplex ; Humans ; Methylmethacrylates ; Polystyrenes ; Vestibular Function Tests

No abstract available.
Schools, Medical*

PURPOSE: Recently many studies show early exposure during childhood growth to endotoxin (lipopolysaccharides, LPS) and/or early exposure to allergens exhibit important role in development of allergy including bronchial asthma. The aim of this study was to evaluate the role of endotoxin and allergen exposure in early life via the airways in the pathogenesis of allergic airways inflammation and airway hyperresposiveness (AHR) in mouse model of asthma. METHODS: Less than one week-old Balb/c mice was used. Groups of mice were received either a single intranasal instillation of sterile physiologic saline, 1% ovalbumin (OVA), LPS or 1.0 microgram LPS in 1% OVA. On 35th day, these animals were sensitized with 1% OVA for 10 consecutive days via the airways. Animals were challenged with ovalbumin for 3 days on 55th days, and airway inflammation, hyperresponsiveness, and cytokine expression were assessed. Measurements of airway function were obtained in unrestrained animals, using whole-body plethysmography. Airway responsiveness was expressed in terms of % enhanced pause (Penh) increase from baseline to aerosolized methacholine. Lung eosinophilia, serum OVA-IgE and bronchoalveolar lavage (BAL) fluid cytokine levels were also assessed. ANOVA was used to determine the levels of difference between all groups. Comparisons for all pairs were performed by Tukey-Kramer honest significant difference test; P values for significance were set to 0.05. RESULTS: Sensitized and challenged mice with OVA showed significant airway eosinophilia and heightened responsiveness to methacholine. Early life exposure of OVA and/or LPS via the airway prevented both development of AHR as well as bronchoalveolar lavage fluid eosinophilia. Exposure with OVA or LPS also resulted in suppression of interleukin (IL)-4, 5 production in BAL fluid and OVA specific IgE in blood. CONCLUSION: These results indicate that antigen and/or LPS exposure in the early life results in inhibition of allergic responses to OVA in this mouse model of astham. Our data show that early life exposure with OVA and/or LPS may have a protective role in the development of allergic airway inflammation and development of allergen-induced airway responses in mouse model of asthma.
Allergens ; Animals ; Asthma ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; Eosinophilia ; Hypersensitivity ; Immunoglobulin E ; Inflammation ; Interleukins ; Lung ; Methacholine Chloride ; Mice ; Ovalbumin ; Ovum ; Plethysmography

PURPOSE: Allergic asthma is a complex syndrome of reactions within the airways characterized by bronchoconstriction, airway inflammation and airway hyperresponsiveness (AHR). There is an emerging body of knowledge defining the role of CD8 (+) T cells in the pathogenesis of allergic asthma. The role of CD8 (+) T cells in the development of allergic airway disease is still controversial. The purpose of this study was to investigate the role of CD8 (+) T cells during the induction of allergen-induced AHR and airway inflammation. METHODS: Mice were sensitized to OVA by i.p. injection on day 1, 14 and then challenged by OVA inhalation on days 24, 25, 26. Anti-CD8 antibody was administered to sensitized mice by i.v. injection 2h before second sensitization and first airway challenge. In vivo airway responsiveness was measured by whole body plethysmography (Penh) to inhaled methacholine (MCh) on day 28. Lung eosinophilia, bronchoalveolar lavage fluid (BALF) cytokine levels were also assessed. RESULTS: Sensitized and challenged mice showed significant airway eosinophilia and heightened responsiveness to methacholine when compared with nonsensitized animals. Administration of anti-CD8 antibody prevented both development of AHR as well as bronchoalveolar lavage fluid eosinophilia. Anti-CD8 antibody abolished peribronchial and perivascular infiltration of inflammatory cells. Treatment with anti-CD8 antibody also resulted in supression of IL-5 production in bronchoalveolar lavage fluid. CONCLUSION: These results indicate that CD8 (+) T cell may have a potential role in the development of allergic airway inflammation and development of allergen-induced airway responses.
Animals ; Asthma ; Bronchoalveolar Lavage Fluid ; Bronchoconstriction ; Eosinophilia ; Inflammation* ; Inhalation ; Interleukin-5 ; Lung ; Methacholine Chloride ; Mice ; Ovum ; Plethysmography, Whole Body ; T-Lymphocytes*

PURPOSE: This study was to identify nursing interventive strategies centering around the meaning structure of elderly women self-esteem. METHOD: This study is based on a phenomenological approach. The participants were 6 women over the age of 65 selected in Mullae Senior Club or Yeongdeungpo Senior Welfare Center. The data was collected by in-depth and open- ended interviews from May to September, 2001. The analysis of the data was used the phenomenological analytic method suggested by Giorgi(1970). RESULT: Two essential themes in the self- esteem of relationships the elderly women emerged: (1) Self-identification through human relations: (2) The ability for self-control. CONCLUSION: There is a variety of programs and social meetings to confirm self and support systems, whether on the governmental level or the personal level, to help the ability for self-control should be expected to live a more qualitative life and successful aging for elderly women. In addition, this study will offer a better understanding of elderly women within the social and cultural context of South Korea.
Aged* ; Aging ; Female ; Humans ; Korea ; Nursing

Some of cerebral palsy patients are accompanied by mental retardation, convulsion, scoliosis and thoracic deformity. We experienced general anesthesia of a 22-year-old male with cerebral palsy accompanied by high degree mental retardation and scoliosis for dental caries therapy. We performed anesthetic management of this patient without any occurrence of anesthesia-related complications, though we had some difficulties in anesthetic induction and postural maintenance during the process. We recognized that considerable attention is needed for the patients with cerebral palsy to avoid undesirable anesthetic complications, especially ventilatory failure and neurologic sequelae.
Anesthesia, Dental ; Anesthesia, General ; Cerebral Palsy* ; Congenital Abnormalities ; Dental Caries ; Humans ; Intellectual Disability ; Male ; Scoliosis ; Seizures ; Young Adult

PURPOSE: Topiramate(TPM) is a new anticonvulsant with multiple action mechanisms which should theoretically represent a wide therapeutic spectrum. However, there is still little clinical experience of its use in Asian children with epilepsy. METHODS: The patients were total 96 children who were treated with more than 2 anticonvulsants but poorly controlled seizure activity. TPM was given as add-on therapy and evaluated the efficacy and adverse events prospectively. This study consisted of 8 weeks of baseline phase, 10- 16 weeks titration phase, and 8 weeks of stabilization phase. Clinical efficacy was classified into 4 groups : disappearance, marked improvement, improvement, no improvement. RESULTS: When TPM was prescribed, a response of >50% reductions in seizure attacks was seen in 90.6% of cases(95.5% of partial type epilepsy) and disappearance was seen in 67.7% of cases (83.3% of generalized type epilepsy). Concommitent with the larger number of anticonvulsants a longer duration of epilepsy and more frequent seizure attack was showed more lower disappearance rate of seizure attack. Adverse event weight loss(9.4%), somnolence(7.3%), dizziness(5.2%), skin rash, decreased cognitive function, nocturia(3.1%) and headache(2.1%) were noted, but were mostly not serious. CONCLUSION: TPM seems to be a promising new broad-spectrum anticonvulsant, which is efficacious and safe in children with intractable epilepsy.
Anticonvulsants ; Asian Continental Ancestry Group ; Child* ; Epilepsy* ; Exanthema ; Humans ; Prospective Studies ; Seizures

Vestibular schwannoma (VS) is a benign tumor typically originated in the schwann cell of vestibular nerve and usually accompany hearing symptom. Microsurgical removal and radiosurgery have a great role for the treatment of VS. Recently radiosurgery has been considered as an alternative or primary treatment for VS with the tremendous increase of patients who were treated with gamma knife radiosurgery (GKS) though microsurgery still takes the premier. By many published results, it is proved that GKS is a effective and noninvasive technique for VS, especially small sized tumors with satisfactory tumor control rate. The authors assumed that GKS can be expected to achieve satisfactory tumor control rate for small VS under 5 cc in volume. A major interest regarding radiosurgery nowadays is to determine the optimal radiation dose for hearing preservation to improve the quality of life of patients. The more high radiation dose are used for effective tumor growth control, the more radiation-related complications like as hearing deficit, the impairment of other cranial nerve function are increased. Since 1990's the mean radiation dose for tumor margin was more than 18 Gy, but there were high complication rate in spite of good tumor growth control. After the year of 2000, under the influence of advanced neuro-imaging techniques and radiosurgical planning system which enable clinicians to do more precise planning, marginal dose for VS has been decreased to 12-13 Gy and the radiation-related complications has been reduced. But because there may be a unexpected radiationinduced complications as time goes by after the latency period, optimal radiation dose for VS should be established on the basis of more long term follow-up observation.
Cranial Nerves ; Follow-Up Studies ; Hearing ; Humans ; Latency Period (Psychology) ; Microsurgery ; Neuroma, Acoustic* ; Quality of Life ; Radiosurgery* ; Vestibular Nerve