1.A Case of Condyloma Acuminatum Showing Malignant Transformation.
Oong KIM ; In Kyung KANG ; Kyu Chul CHOI
Korean Journal of Dermatology 1995;33(4):759-763
Condyloma acuminatum occurs in perianal and genital area by infection of human papillomavirus (HPV) and appeais as fairly soft verrucous papules or a cauliflower-like mass. So far 60 HPV types have been identified. Among them, condyloma acuminatum is predomi-nantly associated with HPV 16, 18 and rarely with 16, 18. HPV 16, 18 is regarded as a high-risk HPV infection because of the association of HPV 16, 18 with Bowens disease, cervical cancer, and anogenital cancer. In additioin, a significant appearance of cervical anaplastic lesions is preceded by condyloma acuminatum and a high prevalence of cervical dysplasia has been found in female consorts of men with geriital warts. Malignant transformation has been observed in rare incidences of condyloma acumina a on the external genitalia. We present a case of condylc ma acuminatum showing malignant transforrnation. The patient also has uterine cervical carcinonia. We detected HPV 16 in the lesion using polymerase chain reaction.
Bowen's Disease
;
Female
;
Genitalia
;
Human papillomavirus 16
;
Humans
;
Incidence
;
Male
;
Polymerase Chain Reaction
;
Prevalence
;
Uterine Cervical Neoplasms
;
Warts
2.An Immunohistochemical Study of the Expression of Factor XIIIa , CD34 , and Mac 387 in Cutaneous Fibrous Tumors.
Hun JUNG ; In Kyung KANG ; Kyu Chul CHOI
Korean Journal of Dermatology 1995;33(6):1038-1045
BACKGROUND: The relationship and differentiation among various dendritic cells of the dermis are unclear. Recently it has hecome possible to identify different subpopulat,ions of dermal dendritic cells using anti-CD34 and anti-factor XIIIa antibodies. OBJECTIVE: To elucidate which cell types the fibrous dermal turnors consist of we compared the staining patterns of these antibodies as well as of anti-Mac 387 antibody which are labeled as inflammatory cells of the monocyte-macrophage lineage. METHODS: Tumors studied included dermatofibrosarcoma protuberans(DFSP, n=2), dermato-fibroma(n=22), neurofibroma, n=27), acrochordon(n=15), keloid, hypertrophic scar(n=10), juvenile xanthogranuloma(n=1, and malignant fibrous histiocytoma (MFH, n=1). We performed immunoperoxidase staining(AUSC technique) with polyclonal anti FXIIIa antibody, monoclonal anti-CD34 antibody, and monoclonal anti-Mac 387 antibody on the formalin-fixed-paraffin-embedded tissue specimens of these fibrous tumors. The intensity of staining was graded as negative, weakly staining, or strongly stainiring. RESULTS: FXIIIa reactivity was strongly present in dendritic and spindle-shaped cells of all dermatofibromas and some nurofibromas(11 of 27 specimens), but absent from the other fibrous tumors. Among these tumors, one of the two DFSPs was uniquely expressed CD34. Dendritic and spindle-shaped cells within tiese tumors were MAC 387 negative. In inflammatory conditions, variable numbers of MAC 38 positive cells were observed, corresponding to histiocytes and mac-rophages, but the labeling of ipithelioid cells and multinucleated foreign body giant cells were variable. CONCLUSION: The findings of significant numbers of FXIIIa positive cells in dermal fibrous tumors studied suggest that thet may be diagnostic utility associated with the use of this antit)ody. In addition, CD 34 expression by the tumor cells can be an extremely useful marker in establishing a definitive diagnosis of IFSP.
Antibodies
;
Dendritic Cells
;
Dermatofibrosarcoma
;
Dermis
;
Diagnosis
;
Factor XIIIa*
;
Giant Cells, Foreign-Body
;
Histiocytes
;
Histiocytoma, Benign Fibrous
;
Histiocytoma, Malignant Fibrous
;
Keloid
;
Langerhans Cells
;
Neurofibroma
3.Radiological analysis of pulmonlary sequestration
Chul Soon CHOI ; Kyung Mo YEON
Journal of the Korean Radiological Society 1984;20(1):59-64
Pulmonary sequestration , defined as loss of connection of the lung tissue with bronchial tree and withpulmonary artery receiving its artery supply from the systemic artery, is very rare cngenital pulmonary disease.It presents as two types, intralobular or extralobular differentiated by its location. 6 cases of pulmonarysequestrations hve been diagnosed in Seoul National University Hospital. 5 cases were confirmed pathologicallyafter lobectomy. 1 case was diagnosed with cardiac cineangiogram only. The results are as follows; 1. 4 cases hadclinical histories of pulmonary sepsis. 2 cases had cardiac problems without suspicion of the lung problem. 2. 4cases are male and 2 cases are female. 3. Ages of the patients are distributed from 2 months of age to 15 years ofage. 4. 4 cases are angiographically confirmed preoperatively. 2 cases had no suspicion of pulmonary sequestrationpreoperatively. 5. 3 cases are associated wtih cardiovascular anomalies such as right sided aortic arch, pulmonarystenosis, complicated heart disease. 6. 5 cases- operatively proven-have intralobar types with cystic change. 7.CT was performed in one case who shows left lower lobe area mass with air bronchogram.
Aorta, Thoracic
;
Arteries
;
Bronchopulmonary Sequestration
;
Female
;
Heart Diseases
;
Humans
;
Lung
;
Male
;
Seoul
;
Sepsis
;
Trees
4.A Case of Atrichia with Papular Lesions.
Oong KIM ; Chang Nam OH ; In Kyung KANG ; Kyu Chul CHOI
Korean Journal of Dermatology 1995;33(1):150-153
Artichia with papular lesions is a rare congenit,al disease characteriezed by the association of alopecia and papular lesions. We report a case of atrichia with papular lesions in 12-year-old. Alopecia of the scalp and eye brows were present at birth. Nurnerous papular lesions are presentation the trunk, buttock and inguinal area. The histopathologic iinding of a papular lesion showed ker till-filled cyst, and eruptive vellous hair cyst. The patient showed reticulat.ed hyperpigmentation on the hands and feet in addition to the characteristic feature of atriclia with papular lesions.
Alopecia
;
Buttocks
;
Child
;
Foot
;
Hair
;
Hand
;
Humans
;
Hyperpigmentation
;
Parturition
;
Scalp
5.A Case of Squamous Cell Carcinoma and Sebaceous Carcinoma Arising from Bowen' s Disease.
Jong Jun PARK ; Hun CHUNG ; In Kyung KANG ; Kyu Chul CHOI
Korean Journal of Dermatology 1995;33(3):575-579
Bowens disease is generally regarded as a premalignant dermatosis. If untreated, 3% to 5% of patients may develop squamous cell carcinoma. However, sebaciou carcinoma arising from Bowens disease is very rare. We presented a case of quarnous cell carcinoma and sebaceous circ s disease in a 68 year-old male. He had multiple bowenoid skin lesi nsties. A bean-sized nodule as developed on the bowenoid lesion of the he had a large yellow crust.ed exudative tumor on the Rt. thigh. We took a biopsy specimen of these three discrete lesions. The nu lipid stain of frozen section revealed Bowens disease, squarnous concllnoma arising from Bowen on the trunk and extremi Rt. lower abdomen. Almost of routine histology and carcinoma, and sebaceous carcinoma, respectively.
Abdomen
;
Aged
;
Biopsy
;
Bowen's Disease
;
Carcinoma, Squamous Cell*
;
Frozen Sections
;
Humans
;
Male
;
Skin
;
Skin Diseases
;
Thigh
6.An immunohistochemical study of plasma fibronectin expression in basal cell carcinoma.
In Kyung KANG ; Byung Soo CHUNG ; Kyu Chul CHOI
Korean Journal of Dermatology 1992;30(2):155-161
Previous observations have demonstrated that fibronectia (FN) is deposited high abundance in basal cell carcinoma (BCC) stroma. Since FN is a glycoprotein which promotes interaction between cells and extracellular matrix, it may been important component of slowly expansile carcinoma such as BCC. Furthermore, BCCs aggressiveness varies with it's histologic appearance. The authors investigated distribution of plasma FN (pFN) in 8 BCC cases with various histologic types (3 nodulocystic type, 2 infiltrative type, 2 keracotic type, 1 adenoid type) and 4 squamous cell carcinomas (SCC), which have a more aggrcisive biologic behavior than BCC using immunohistochemical staining. In normal skin, pFN was strongly positive at the clenzoepidermal junction and perivascular area with a linear pattern, and in the papillary dermis with a reticular pattern, and was weakly positive in the reticular dermis. In BCC, pFN was strongly positive in nodulocystic BCC, with the highest concentration along the periphery of the tumor island in a filamentous pattern, .hereas, it was moderately positive in adenoid, keratotic, infiltrative BCC stroma. In SCC, pFN was weakly positive around tumor the margins with a thin, coarse deposition These results show that with epidermal tumors, the degree of the pFN expression in stroma is propotional to their aggressiveness.
Adenoids
;
Carcinoma, Basal Cell*
;
Carcinoma, Squamous Cell
;
Dermis
;
Extracellular Matrix
;
Fibronectins*
;
Glycoproteins
;
Plasma*
;
Skin
7.An immunohistochemical study of tubulin expression in skin tumors.
Kyung Jin KIM ; Byoung Soo CHUNG ; Kyu Chul CHOI
Korean Journal of Dermatology 1991;29(2):174-180
Using immunohistochemical methods, the authors investigated the distribution of tubulin in normal skin and 31 skin tumors, including 11 benign skin tumors and 20 malignant skin tumors, In normal skin, tubulin was strongly expressed in basal cells of the epidermis, sebaceus celis and dermal nerves. Myoepithelial cells, ductalI cells of sveat ducts and outer root sheath cells of hair follicles stained moderat,ely. Lermal fi broblasts showed no staining. In benign tumors including keratoacanthoma, trichoepithelioma, and nevocellular nevus the strornal fibroblast.s were entirely tubulin negative as well as the turnor cells. In basal cell carcinoma, the stromal fibroblasts were negative',whereas tumor cells were weakly positive. In squarnous cell carcinoma(SCC), tumor cells weri, tubulin positive weakly, the degree of tubulin expression of its stroma1 fibroblasts tencied to be in proportional to the grade of malignanr.u. Tumor cells of malignant melanoma and nevocellular nevus were tubulin positive moderately bist the stromal fibrobla.sts were strongly positive only in the cases of malignant melanoma. These results show that the degree of the tubulin; expression in adjacent, stromal cells of epidermal tumors is in proportiona.l to that of their malignancy, These suggest that the expression of tubulin in fibroblasts surrounding tumor cells of malignant melanoma and SCC reflects a stromal alt,eration that might contribute to tumor in vasion, and play a role for cellular motility.
Carcinoma, Basal Cell
;
Epidermis
;
Fibroblasts
;
Hair Follicle
;
Keratoacanthoma
;
Melanoma
;
Nevus
;
Skin*
;
Stromal Cells
;
Tubulin*
8.A case of cutaneous bronchogenic cyst.
In Kyung KANG ; Byung Soo CHUNG ; Kyu Chul CHOI
Korean Journal of Dermatology 1991;29(5):658-661
No abstract available.
Bronchogenic Cyst*
9.THE EffECT OF THE 5-FLUOROURACIL ON THE HAIR OF RAT: SCANNING ELECTRONMICROSCOPIC STUDY
Yong Chul CHOI ; Kyung Wook KIM ; Jae Hoon LEE
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1998;20(2):158-165
Animals
;
Body Weight
;
Fluorouracil
;
Hair
;
Rats
;
Rats, Sprague-Dawley
10.A Case of Malignant Histiocytosis.
Moon Hee HONG ; Jong Jun PARK ; In Kyung KANG ; Kyu Chul CHOI ; Sung Chul LIM
Annals of Dermatology 1996;8(3):201-205
Malignant histiocytosis is a rare, usually fatal malignant neoplasm of reticuloendothelial systems. The disease is associated with fever, malaise, weight loss, hepatosplenomegaly, lymphadenopathy, pancytopenia, jaundice, and purpura. A 44-year-old female patient is described who had multiple, purple crusted nodules and plaques in the skin. In the laboratory study, pancytopenia was noted on the peripheral blood. In addition many atypical histiocytes were seen on the bone marrow aspiration. A lesional biopsy showed nodular infiltrations of atypical histiocytes in the dermis and some erythrophagocytosis was seen. Immunohistochemically, the histiocytes were weakly stained for lysozyme and α-l-antichymotrypsin, but were unstained for S-100 protein, cytokeratin, CEA(carcinoembryonic antigen), pan T/B marker CD30(ki-1), UCHL-1 LCA(leukocyte common antigen), and α-l-antitrypsin.
Adult
;
Biopsy
;
Bone Marrow
;
Dermis
;
Female
;
Fever
;
Histiocytes
;
Histiocytic Sarcoma*
;
Humans
;
Jaundice
;
Keratins
;
Lymphatic Diseases
;
Mononuclear Phagocyte System
;
Muramidase
;
Pancytopenia
;
Purpura
;
S100 Proteins
;
Skin
;
Weight Loss