1.Common Epilepsy in Childhood.
Seung Yun CHUNG ; Kyung Tai WHANG
Journal of the Korean Pediatric Society 2003;46(Suppl 2):S262-S276
No abstract available.
Epilepsy*
2.Changes of Prostaglandin E-2 Levels in Cerebrospinal Fluid in Children with Febrile Convulsion.
Byung Joon CHOI ; Kyung Tai WHANG
Journal of the Korean Child Neurology Society 1998;5(2):235-241
PURPOSE: Prostaglandins(PGs) are known to produce a remarkably broad spectrum of effects that embraces practically every biological function, and has a particular physiological role in the central nervous system. Significant increases of PGs levels are seen in certain diseases, such as febrile infection, stroke, schizophrenia, and epilepsy. Prostaglandin is also increased in a response to rising body temperature, and prostaglandin E-2(PGE-2) in lumber cerebrospinal fluid is also increased in febrile convulsion. Intracerebroventricular injection of PGE produces a rise in body temperature and also antagonizes convulsions induced by pentylenetetrazole, penicillin, electric shock. Therefore we studied PGE-2 levels in cerebrospinal fluid of afebrile children, children with febrile convulsion, and febrile children without convulsion. METHODS: The subjects comprised 57 cases with febrile convulsion, 24 cases of afebrile diseases and 9 febrile children without convulsion. All patients were undergoing lumbar puncture and PGE-2 levels in CSF were determined by highly specific radio-immunoassay(Prostaglandin E2 [125I] assay system, Biotra Assays, Amersham Inc.). RESULTS: 1) The CSF PGE-2 levels were significantly higher in children with febrile convulsion(147.3+/-79.3pg/ml) than those in febrile children without convulsion(72.4+/-75.4pg/ml) and afebrile children(19.2+/-28.4pg/ml)(p<0.05). 2) There were no statistical significances of the CSF PGE-2 levels between age and fever in both groups. 3) The CSF PGE-2 levels within 4 hours(176.5+/-65.7pg/m1) after convulsions were significantly higher than those 4 hours after convulsion(93.3+/-74.9pg/ml). CONCLUSION: The CSF PGE-2 levels were significantly higher in children with febrile convulsion than those in febrile children without convulsion and those in afebrile child ran. The CSF PGE-2 levels within 4 hours after convulsion were significantly higher than those 4 hours after convulsion.
Body Temperature
;
Central Nervous System
;
Cerebrospinal Fluid*
;
Child*
;
Epilepsy
;
Fever
;
Humans
;
Penicillins
;
Pentylenetetrazole
;
Prostaglandins E
;
Prostaglandins I
;
Schizophrenia
;
Seizures
;
Seizures, Febrile*
;
Shock
;
Spinal Puncture
;
Stroke
3.A Case of Werdnig Hoffmann Disease.
Woo Jung KIM ; Dong Ku LEE ; Kyung Tai WHANG
Journal of the Korean Pediatric Society 1985;28(1):103-106
No abstract available.
Spinal Muscular Atrophies of Childhood*
4.The effects of antiepileptic drugs on serum carnitine and liver function.
Soo Jung LEE ; Jong Wan KIM ; Kyung Tai WHANG
Journal of the Korean Child Neurology Society 1993;1(2):112-121
No abstract available.
Anticonvulsants*
;
Carnitine*
;
Liver*
6.A clinical study on childhood epilepsy.
Jong In BYUN ; Young Hoon KIM ; In Goo LEE ; Kyung Tai WHANG
Journal of the Korean Child Neurology Society 1993;1(1):99-105
No abstract available.
Epilepsy*
7.Four Cases of Congenital Choledochal Cyst.
Hyun Eog YANG ; Yoon Hee LEE ; Kyung Tai WHANG
Journal of the Korean Pediatric Society 1986;29(11):108-114
No abstract available.
Choledochal Cyst*
8.Modulatory Effects of Imipramine on Pilocarpine-induced Seizures in Immature Rats.
In Goo LEE ; Young Hoon KIM ; Kyung Tai WHANG
Journal of the Korean Child Neurology Society 1998;5(2):207-216
PURPOSE: Norepinephrine has modulatory effects on neuronal excitability and, in some cases, has a proconvulsant effect. Intraperitoneal imipramine treatment increases norepinephrine level, and to a lesser extent, dopamine and serotonin in brain dialysate from rats. We sought to determine the effects of imipramine on pilocarpine-induced seizures in the immature rats. METHODS: Right and left cortical and hippocampal electrodes were placed in 10~15 day old Sprague-Dawley rats. The following day 3-hour video EEG recordings were obtained to monitor electrographic seizures and status epilepticus induced by intraperitoneal injection of high dose(200mg/kg : HD) and low dose (75mg/kg : LD) pilocarpine. A first group of rats received HD pilocarpine alone(n=25), or pretreatment with 0.5(n=6). 1(n=6), 2(n=6), 5(n=6), or 10(n=11)mg/kg of imipramine. A second group of rats received LD pilocarpine alone(n=6) or pretreatment with 2mg/kg of imipramine (n=6). Data were analyzed using the Fisher exact test. RESULTS: Treatment with HD pilocarpine alone resulted in electrographic seizures in 76%(n=19) and status epilepticus in 44%(n=11). In the HD pilocarpine group, status epilepticus was seen in 100% of rats pretreated 1, 2, and 5mg/kg imipramine. 90.9% of the rats pretreated with 10mg/kg of imipramine developed seizures and 36.4% developed status epilepticus. Imipramine at 0.5, 1,2, and 5mg/kg increased the incidence of seizures and status epilepticus in the HD pilocarpine group, but the incidence was statistically significant only for status epilepticus(p<0.05). The latency for the occurrence of first status epilepticus was 12.3+/-1.3 min in the HD pilocarpine alone group, and it was 21+/-3.8 min and 25.3+/-5.7 min in the group pretreated with 5 and 10mg/kg imipramine, respectively(p<0.02). Treatment with LD pilocarpine alone resulted in seizures in 50% and status epilepticus in 16.7%. In the LD pilocarpine group with imipramine 2mg/kg pretreatment, 83.3% had seizures and status epilepticus. Imipramine at 2mg/kg increased the incidence of seizures and status epilepticus in the LD pilocarpine group, but the increase was statistically significant only for status epilepticus(p<0.05). CONCLUSION: Imipramine exhibits a proconvulsant effect at low doses and an anticonvulsant effect at high doses in the pilocarpine seizure model in immature rats. There may be a dose-dependent effect on monoaminergic receptors which results in increased neuronal excitability.
Animals
;
Brain
;
Dopamine
;
Electrodes
;
Electroencephalography
;
Imipramine*
;
Incidence
;
Injections, Intraperitoneal
;
Neurons
;
Norepinephrine
;
Pilocarpine
;
Rats*
;
Rats, Sprague-Dawley
;
Seizures*
;
Serotonin
;
Status Epilepticus
9.Immunologic Changes in Bronchial Asthma on Immunotherapy.
Joon Sung LEE ; Kyung Tai WHANG ; Sung Hoon CHO
Journal of the Korean Pediatric Society 1990;33(9):1255-1261
No abstract available.
Asthma*
;
Immunotherapy*