Fifty-nine knees with a specific diagnosis of mediopatella plica syndrom; under arthroscopy were treated by arthroscopic resection. The patients were se1ected for arthroscopy only if the symptoms had continued after a course of physical therapy and medication for at least three weeks. Seven patients were lost in follow up period. Fifty-two knees were reviewed after mean period of 21.5 monl;hs (range 12 to 37). The results were graded as excelient (61.5%), good (25%), poor (9.6%) and failure (3.9%). Majority of the patients ratect their result as excellent or good. We concluded that with the meticulous resection of the pathologic plica with arthroscopy, good result can he expected with resumption of athletic activities and no or mild pain in knee joint.
Arthroscopy ; Diagnosis ; Follow-Up Studies ; Humans ; Knee Joint* ; Knee* ; Sports

No abstract available.
Animals ; Microscopy, Electron* ; Muscle Fibers, Skeletal* ; Muscle, Skeletal* ; Rats*

Some herbal medications induce acute kidney injury. The acute kidney injuries caused by herbal medications are mild and commonly treated by palliative care. A 51-years-old man who drank the juice squeezed from the raw tubers of Dioscorea quinqueloba (D. quinqueloba) was admitted with nausea, vomiting and chilling. He developed a seizure with decreased level of consciousness. He was diagnosed with acute kidney injury, which was cured by continuous venovenous hemodialfiltration. Non-detoxified D. quinqueloba can cause severe acute kidney injury with toxic encephalopathy. It is critical to inform possible adverse effects of the medicinal herbs and to implement more strict regulation of these products.
Acute Kidney Injury/*chemically induced/*complications ; Dioscorea/*adverse effects ; Disease Progression ; Electroencephalography ; Humans ; Length of Stay ; Male ; Middle Aged ; Neurotoxicity Syndromes/*complications

Microinvasive carcinoma of the uterine cervix(FIGO stage IA) has been reported as highly curable disease even with conservative surgery such as conization and simple hysterectomy. Nevertheless, the surgical management for microinvasive carcinomas has been proposed varying from conservative surgery to radical hysterectomy with pelvic nodes dissection according to different diagnostic criterias for microinvasive carcinoma. We reviewed 512 patients who had been diagnosed as microinvasive carcinoma of the uterine cervix at the Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center from Jan. 1988 to Dec. 1995. Among them, 376 patients were included in this study satisfying guided criterias such as proper management and follow up more than at least one year, and they were analyzed retrospectively based on the clinicopathologic characteristics, pattern of surgical management and postoperative status. (continue)
Cervix Uteri* ; Conization ; Delivery of Health Care ; Diagnosis* ; Female ; Follow-Up Studies ; Gynecology ; Humans ; Hysterectomy ; Obstetrics ; Retrospective Studies

To analyze the effects of capsaicin administered to the arthritic rat model, immunohistochemical stains for c-fos protein in the spinal dorsal horn and for substance P and CGRP in the dorsal root ganglia (DRG) were done. Kaolin and careegenan were administered to the knee joint cavity of adult rats to induce arthritis, and capsaicin was administered immediately after kaolin-careegenan injection. A count was conducted of the c-fos immunoreactive dorsal horn neurons and substance P and CGRP immunoreactive cells in L5 and L6 DRG to elucidate the effect of capsaicin. The results were summarized as follows. 1. The number of c-fos immunoreactive neurons in the superficial dorsal horn was increased markedly 2 hours after the kaolin and careegenan injection to the knee joint, and decreased gradually to the control level 1 week after injection. 2. The number of c-fos immunoreactive neurons in the superficial dorsal horn of capsaicin- treated rats was less than in those rats not injected with capsaicin. 3. The number of c-fos immunoreactive neurons in the deep dorsal horn was increased later than those in the superficial dorsal horn and reached peak level 16 hours after the kaolin and careegenan injection, and decreased gradually therafter. 4. The number of c-fos immunoreactive neurons in the deep dorsal horn of the capsaicin treated rats was less than in those rats not treated with capsaicin. 5. The number of substance P and CGRP immunoreactive DRG neurons increased 24 hours after the kaolin and careegenan injection to the knee joint, and also apparently increased 1 week after injection. 6. The number of substance P and CGRP immunoreactive DRG neurons of capsaicin- treated rats was less than in those rats not treated with capsaicin administered rats. Capsaicin reduces the number of c-fos immunoreactive neurons in the spinal dorsal horn, and also reduces the number of substance P and CGRP immunoreactive neurons in the DRG of the arthritic rat model, which may be closely related to the analgesic effects of capsaicin.
Adult ; Animals ; Arthritis ; Capsaicin* ; Coloring Agents ; Diagnosis-Related Groups ; Ganglia, Spinal* ; Horns ; Humans ; Kaolin ; Knee Joint ; Models, Animal* ; Neurons ; Posterior Horn Cells ; Rats* ; Spinal Cord* ; Spinal Nerve Roots* ; Substance P

PURPOSE: Insulin like Growth Factor-1 (IGF-1) promotes the proliferation and migration of penile cavernous smooth muscle cells in rats. The goal of this study was to investigate the effects of an intracavernosal injection of the IGF-1 gene on the erectile function in the aging rat. MATERIALS AND METHODS: Corpus cavernosum smooth muscle cells (CCSMCs) were primarily cultured from Sprague-Dawley rats (16 wks). IGF-1 cDNA was subcloned into pcDNA3.1, and this expression plasmid transfected into CCSMCs. Two, three and four days after transfection, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot analyses were carried out to quantify the transfection efficiency. In an in vivo study, male F344 rats (n=28) were divided into 2 groups; the young (5 months; n=7) and the old (20-21 months; n=21) groups. The old group was further divided into control (n=7) and treatment groups (n=14). The treatment group was given a single intracavernosal injection of DNA-liposome complex (pcDNA alone and pcDNA/IGF-1; 2mug or 4mug in 7 animals each). After 4 weeks of treatment, the erectile function and corpus cavernosal histology were evaluated by hemodynamic study and histomorphometric analysis, respectively. RESULTS: When the CCSMCs were transfected with IGF-1, the IGF-1 mRNA and protein were overexpressed compared to the control. After 4 weeks of treatment, the ratio of the peak intracavernosal pressure to systemic arterial pressure increased in the treatment group (66.3+/- 4.3% with 2mug, 65.4+/- 10.2% with 4mug), but without statistical significance (p>0.05) compared to the control group (55.5+/- 16.7%). The percentage of cavernosal smooth muscle also slightly increased in the treatment group (14.1+/-1.7% with 2mug), but without statistical significance (p>0.05) compared to the control group (13.2+/-1.2%). CONCLUSIONS: IGF-1 mRNA and IGF-1 protein were overexpressed in the rat corpus cavernosum smooth muscle cells due to IGF-1 gene delivery. However, lipid-mediated intracavernosal gene delivery of IGF-1 did not significantly improve the erectile function in the aging rat.
Aging* ; Animals ; Arterial Pressure ; Blotting, Western ; DNA, Complementary ; Erectile Dysfunction ; Hemodynamics ; Humans ; Insulin ; Insulin-Like Growth Factor I* ; Male ; Muscle, Smooth ; Myocytes, Smooth Muscle ; Plasmids ; Rats* ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger ; Transfection

PURPOSE: Posttraumatic nasal deformities might not be corrected adequately by conventional osteotomy techniques when the configuration of the nasal bone has been changed due to malunion. To consistently obtain good aesthetic and functional results, the anatomic reduction of malunion sites of the nasal bone is important. The purpose of this study is to present an osteotomy technique, including refracture along malunion sites and anatomical reduction of a malformed nasal bone, for the correction of a posttraumatic deviated nose. METHODS: From March of 2003 to May of 2004, 27 patients, who underwent corrective rhinoplasty for the correction of bony pyramid deviation, were included in this study. Postoperative results of the technique were evaluated objectively at 1 year after surgery regarding nasal midline location, nose symmetry, and nasal contour. Results were rated as excellent, good, fair, or poor. All patients were also evaluated subjectively for cosmetic improvement, changes in breathing, and overall satisfaction. RESULTS: Objective analysis of the outcomes revealed an excellent result in 17 patients(63%), good in 9(33%), and fair in 1 patient(4%). No case evaluated had a poor result. Regarding subjective analysis, 19 patients(70%) evaluated the cosmetic outcome as perfect. Among the 21 patients with preoperative airway problems, 19 patients(90%) reported improved breathing post-operatively. Patients' overall satisfaction levels were also very positive. No postoperative complications occurred during the 14 month mean follow-up period. CONCLUSION: The osteotomy technique presented in this study is simple, effective, and safe for correcting posttraumatic nasal deviation, and also produces consistent results.
Congenital Abnormalities ; Follow-Up Studies ; Humans ; Nasal Bone ; Nose* ; Osteotomy* ; Postoperative Complications ; Respiration ; Rhinoplasty*

PURPOSE: The presence of lymph-node metastases is one of the most important prognostic factors for patients with a colorectal carcinoma. The sentinel lymph node is the first lymph node that receives afferent lymphatic drainage from a primary tumor, and thus has the highest risk of harboring metastatic disease. METHODS: Twenty-eight patients with an adenocarcinoma of the colon or the rectum were investigated. After resection of the specimen in standard oncologic fashion, the specimen was dissected longitudinally along the antimesenteric border, and methylene blue was injected around the tumor submucosally. After 5 minutes, the mesentery was meticulously examined, and blue-stained lymphatics and lymph nodes were carefully dissected and harvested. RESULTS: Sentinel lymph nodes were identified in all cases. The average number of sentinel nodes identified was 3 (range, 1~6), and the average number of lymph nodes retrieved was 20.8 (range, 6~42). Of the fifteen patients (53.6%) identified to be positive for lymph-node metastasis 10 showed nonsentinel nodal metastasis without sentinel nodal involvement. No additional isolated tumor cells were found by immunohistochemical staining in 13 patients who had no lymph-node metastasis on conventional pathologic examination. CONCLUSIONS: In colorectal cancer, the sentinel-lymph-node sampling method is easy and can be performed for the purpose of finding lymph nodes easily. However, applying the sentinel-lymph-node sampling method for the purpose of minimizing lymph node dissection, as in breast cancer, is not recommended because of the high probability of missing metastasis.
Adenocarcinoma ; Breast Neoplasms ; Colon ; Colorectal Neoplasms ; Drainage ; Humans ; Lymph Node Excision ; Lymph Nodes ; Mesentery ; Methylene Blue ; Neoplasm Metastasis ; Nitriles ; Pyrethrins ; Rectum

It is well recognized that malnutrition is one of the most important reversible factors contributing to mortality in hemodialysis patients. Until recently, highprotein diets were recommended for hemodialysis patients in an attempt to increase the synthesis of albumin and to promote the anabolism of body protein. However, the appropriateness of this recommendation has recently been questioned. This study investigated the effects of low and high protein intakes on the levels of serum albumin, total protein, BUN, and creatinine in 28 hemodialysis patients fed sequentially 1.0g(LPG) or 1.5g(HPG) protein and 30-35kcal/kg/ ideal body weight for four weeks. The HPG diet was associated with a significant increase in the levels of serum albumin, total protein, BUN, and creatinine however, the LPG diet was not. The serum levels of triglyceride and total cholesterol were in the normal range and did not changed by the diets. The levels of serum Hb, iron, and transferrin were lower than the normal values and did not changed by these two diets. Though individual considerations are recommended, it is possible that the high protein diet could increase the levels of serum albumin and total protein of the hemodialysis patients in Korea.
Cholesterol ; Creatinine ; Diet ; Diet, Protein-Restricted ; Humans ; Ideal Body Weight ; Iron ; Korea ; Malnutrition ; Metabolism ; Mortality ; Nutritional Status* ; Penicillin G Benzathine ; Reference Values ; Renal Dialysis* ; Serum Albumin ; Transferrin ; Triglycerides

Solitary fibrous tumors (SFT) are rare spindle-cell neoplasms that are found principally in the pleura, and extrathoracic SFTs are even less common. We report here on a case of malignant solitary fibrous tumor in the perianal region. A 47-year-old man was referred to our hospital for surgical treatment of an incidentally discovered perianal mass. Pelvic MRI showed a slightly lobulated solid mass with central necrosis in the ischiorectal fossa. We performed complete removal of tumor with using a postanal approach. The resected specimen was 6.5x5.0x5.0 cm in size, and it was an elastic solid tumor with invasion to the surrounding muscle structures. Histologically, the tumor was composed of a patternless proliferation of spindle cells with a collagenous matrix and the tumor cells showed increased cellularity, cellular pleomorphism and frequent mitotic figure. Immunohistochemical staining was positive for CD34 and negative for desmin, which indicated malignant SFT. We report here on a rare case of malignant SFT in the perianal region along with a review of the literature.
Collagen ; Desmin ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Necrosis ; Pleura ; Solitary Fibrous Tumors*