No abstract available.

OBJECTIVES: The purpose of this study is to investigate the Korean adolescent attachment patterns and their relations to parenting behaviors. METHODS: The subjects of this study were 792 high school students in Seoul. We assessed parenting behaviors perceived by adolescents and attachment type and quality of using Parenting Behavior Inventory, Self-report Attachment Style and Revised Adult Attachment Scale. RESULTS: 1) On the attachment pattern of adolescent, it revealed that 47.6% of the subjects were classified as "secure", 32.2% as "preoccupied", 14.6% as "dismissing" and 5.6% as "fearful". 2) The parental neglect was related to fearful and preoccupied patterns and parental inconsistency was related to preoccupied pattern. In terms of attachment quality and parental behavior, more parental affection and reasoning were related with more reliance. And more affection and less intrusiveness, neglect, and inconsistency were related with more closeness. More affection and reasoning and less physical abuse, intrusivenes, over-expectation, neglect, inconsistency were related with less anxiety. CONCLUSIONS: This study shows that adolescent attachment pattern would be transitional compared with that of infancy and adult. More positive parenting behavior such as affection and reasoning, and less negative parenting behavior such as physical abuse, intrusiveness, neglect, inconsistency were related with secure attachment pattern. Also, less positive parenting behavior such as affection and reasoning, and more negative parenting behavior such as physical abuse, intrusiveness, neglect, inconsistency were related with insecure attachment patterns.
Adolescent* ; Adult ; Anxiety ; Humans ; Parenting* ; Parents* ; Seoul

No abstract available.
Emergencies* ; Emergency Service, Hospital*

OBJECTIVE: The purpose of this study was to examine the relationship between attachment and behavior problems in adolescents. METHOD: A sample of 792 high school students were examined. Revised Adult Attachment Scale, Self-report Attachment Style, Youth Self-Report Child Behavior Checklist (YSR) were used to measure the attachment quality, the attachment pattern and the behavior problems respectively. RESULTS: As to the attachment quality, high score in fear of rejection, low dependability and low intimacy were related to the development of adolescent's internalizing problems. As to the attachment pattern, preoccupied and fearful with attachment experience were linked to the internalizing behavior problems of higher level as well as 'Attention problems' and 'Aggressive behavior' sub-scales of externalizing ones on YSR. CONCLUSION: High fear of rejection, low dependability and low intimacy characterise the insecure attachment. So the insecure attachment might predict the development of all internalizing behavior problems, attention problems and aggressive behavior in adolescents. Also the result suggested that the adolescents classified as Dismissing attachment may have a positive view of the self and may minimize the self reported behavior problems.
Adolescent* ; Adult ; Checklist ; Child ; Child Behavior ; Humans ; Self Report

No abstract available.
Humans* ; Receptors, Adrenergic* ; Steroids*

Background: Big data reports related to diseases and health care for the Korean population have been published since the National Health Insurance Service (NHIS) and the Health Insurance Review & Assessment (HIRA) Service provided limited open access to their databases. Here, we reviewed the structure, content, and means of using data from the National Health Insurance (NHI) system for the benefit of Korean researchers and presented the latest publication trends in Korean healthcare data procured from the NHI and HIRA databases. Methods: Since 2013, researchers have been able to obtain nationwide population-based studies using the NHI and HIRA databases of the insured. We searched publications using the NHI and the HIRA databases between 2013 and 2019 retrieved from PubMed. Results: The NHI and HIRA databases provide nationwide population-based data. The total number of publications from 2014 to 2019 using NHI and HIRA databases is 2,541 and 655, respectively. A total of 5,465 endocrinology-related studies were performed during 2014 to 2019. Conclusion The NHIS and HIRA databases have provided tools for guidelines to approach world-leading population-based epidemiology and disease research.

BACKGROUND: Endometrial carcinomas are pathogenetically classified into two major types; endometrioid carcinoma (EC) and serous carcinoma (SC). The most frequently altered gene in EC is the PTEN tumor suppressor gene (TSG). SC is usually associated with mutations in the p53 TSG. METHODS: To further determine the role of PTEN and p53 mutation in endometrial carcinogenesis, the analysis of 33 endometrial carcinomas, including 28 ECs and 5 SCs, for loss of heterozygosity (LOH) on 10q23 and for mutation in all 9 coding exons of PTEN and the 5-8 exons of p53, using SSCP-PCR methods was carried out. RESULTS: LOH was detected in at least one marker in 12 (54.5%) of 22 ECs, but in only one (20.0%) of 5 SCs. Somatic PTEN mutations were detected in 10 (35.7%) of 28 ECs. PTEN was altered in 67.9% of ECs and in 20.0% of SCs, including those with 10q23 LOH. No PTEN mutations were found among the SCs. Somatic p53 mutations were detected in 2 (7.1%) of 28 ECs and 3 (60.0%) of 5 SCs. CONCLUSIONS: PTEN gene alterations contribute to the pathogenesis of an endometrioid subtype of endometrial carcinoma, but not to the serous type. In contrast, p53 plays an important role in the pathogenesis of SCs.
Carcinogenesis ; Carcinoma, Endometrioid ; Clinical Coding ; Endometrial Neoplasms* ; Exons ; Female ; Genes, p53 ; Genes, Tumor Suppressor ; Loss of Heterozygosity

OBJECTIVES: Study results of association between dopamine transporter gene(DAT1) and attention deficit hyperactivity disorder(ADHD) were not conclusive. Distribution of DAT1 polymorphism is variable according to ethnicity. Ethnic differences in the distribution of DAT1 can be an impediment to apply previous findings to Korean ADHD. This study was to examine the association between DAT1 and ADHD, and the risk allele of ADHD among DAT1 polymorphism in Korean. METHODS: DNA extracted from blood of 100 normal controls and 44 ADHD patients. DAT1 with variable number of tandem repeats(VNTR) were determined using polymerase chain reaction. The differences of allelic frequency distribution and genotype frequency distribution between patient group and control group were tested with Fisher's exact test. The pairs of allele and of genotype with difference between the two groups were selected by Fisher's excat test adjusting p-values with permutation method. Odds ratios of two alleles and of two genotypes between the two groups were computed. RESULTS: There was association between DAT1 and ADHD(genotype: p<0.05, allele: p<0.05. Patients with ADHD were more likely to have 440 base pairs than 480 base pairs comparing to controls (OR=4.46, 95% CI: 1.44-13.75). Patients with ADHD were more likely to have 9/10 genotype than 10/10 genotype comparing to controls(Odd Ration=3.74, 95% Confidence Interval: 1.11-12.61). CONCLUSIONS: We found the association between DAT1 and ADHD, and possible risk allele of Korean ADHD. Replication of the results in larger sample is needed.
Alleles ; Attention Deficit Disorder with Hyperactivity* ; Base Pairing ; DNA ; Dopamine Plasma Membrane Transport Proteins* ; Dopamine* ; Genotype ; Humans ; Odds Ratio ; Polymerase Chain Reaction

OBJECTIVES: This study aims to develop a Korean version of the Strengths and Difficulties Questionnaire (SDQ-Kr). METHODS: The Strengths and Difficulties Questionnaire (SDQ) is a brief behavioural screening questionnaire that can be completed by the parents within 5 minutes and used to assess the psychopathology (prosocial behaviour, hyperactivity, emotional problems, conduct problems, and peer problems) of 4-16 year olds. The SDQ was translated into Korean, retranslated back to English, and corrected after discussion with the original developer and trial test. The reliability and validity of the SDQ-Kr was evaluated by working with 347 parents of nonclinical (n=98), pediatric outpatient (n=92), and psychiatric outpatient (n=157) children. RESULTS: Working with 62 parents of nonclinical children, the test-retest reliability of 5 subscales of SDQ-Kr was 0.94-0.84 (p<0.01). For 190 nonclinical and pediatric children, internal consistency of 5 subscales of SDQ-Kr was 0.80-0.50 (Cronba-ch's alpha). Factor analysis generated the five identical factors with the five subscales explaining 49.5% of total variance. For 347 children of nonclinical, pediatric, and psychiatric group, ANOVA showed that any two among the three groups was significantly different in subscales and total difficulties scores, except between pediatric and psychiatric children in emotional problems subscore (p<0.01). The discriminating rate among three groups was 75.5% in discriminant analysis. CONCLUSIONS: The Korean version of SDQ shows very similar psychometric performance to the original SDQ developed by Goodman. This study gives evidence of the usefulness of the SDQ-Kr as a promising screening instrument for epidemiological research and clinical purposes.
Analysis of Variance ; Child ; Discriminant Analysis ; Factor Analysis, Statistical ; Humans ; Mass Screening ; Outpatients ; Parents ; Psychometrics ; Psychopathology ; Questionnaires* ; Reproducibility of Results

OBJECTIVES: Identifying children with Attention-Deficit/Hyperactivity Disorder (ADHD) and providing early therapeutic interventions for them are important to prevent secondary problems in academic achievement and emotional disturbances. The aims of the study is to examine the characteristics of K-ARS for parents and teachers, a screening questionnaire to identify children with ADHD, by age and sex of the children, to examine its clinical validity, and to provide norm data of K-ARS for school-aged children which will facilitate the use of K-ARS in clinical practice and research. METHODS: Randomly selected 1st to 6th graders of the two elementary schools (N=1044) in Anyang City participated in this study. Twenty three children diagnosed with ADHD at the child and adolescent clinic at the Hallym University Sacred Heart Hospital were included in this study for the analysis of validity. Parents and teachers completed K-ARS. Descriptive statistics, t-test and analysis of variance were performed. RESULTS: K-ARS scores showed significant difference according to the gender, with boys having higher scores than girls. There was no significant difference of the scores by ages. Validity analysis showed that K-ARS distinguishes children with ADHD from children without ADHD well. The normative data were presented by age and sex. CONCLUSION: K-ARS for parents and teachers has an excellent clinical validity to discriminate children with ADHD from children without ADHD. Different normative data of K-ARS need to be used due to the gender difference. K-ARS is a useful tool for screening and identifying children with ADHD. Future studies are required to include larger samples with adolescents in various geographic areas.
Adolescent ; Affective Symptoms ; Child ; Female ; Gyeonggi-do ; Heart ; Humans ; Mass Screening ; Parents* ; Surveys and Questionnaires