No abstract available.
Orbit*

A case of mucous gland adenoma arising from the main bronchus of the middle lobe of the right lung is reported, with review of related literatures. The patient, a 12 year-old Korean male, was admitted to Pusan National University Hospital with complaints of progressive coughing and dyspnea. Roentgenographic studies revealed a well defined mass involving the right middle lobe of the lung. With the impression of benign tumor, right middle lobectomy was performed. The gross specimen revealed a polypoid mass involving the main bronchus, measuring 4.5x 3.7 x 2.5cm. The cut surface of the mass revealed yellow-gray myxoid tissue. Histologically, the mass consisted of glandular structures filled with mucus, which proved to be acid one on histochemical study. The glandular lining was made up of a single layer of berign mucous cells, many of them being flattened.
Adenoma

This study was performed with the purpose of histochemical comparison of CEA and EMA localization between adenoma and well-differentiated adenocarcinoma of the stomach. The specimen was 12 lesions of adenoma and 15 foci of well-differentiated adenocarcinoma of the stomach. The markers in neoplastic tissue and neighbouring mucosa of the tumors were examined in paraffin sections using peroxidase-antiperoxidase method. The data obtained were evaluated statistically. The results were summarized as follows: 1) In 12 lesions of stomach adenoma, the positive reaction to CEA was seen in 3 lesions (20.0%), and to EMA in 10 lesions (83.3%). The positive rate of CEA in adenoma was lower than that of the neighbouring normal mucosa, but the positive rate of EMA was similar between the two. 2) In 15 foci of well-differentiated adenocarcinoma of the stomach, the positive reaction to CEA was seen in 13 foci (86.7%), and to EMA in 12 foci (80.0%). The positive rate of CEA in well-differentiated adenocarcinoma was higher than that of the neighbouring normal mucosa, while the positive rate of EMA was similar to each other. 3) Immunoreactivity to CEA in adenocarcinoma showed good positive correlation with the development of cuticular border of the neoplastic glands, while reactivity to EMA in adenocarcinoma was not related with the development of cuticular border. 4) The positive rate and intensity of CEA reaction in adenocarcinoma were higher than those in adenoma, but the positive rate and reactiveity of EMA were similar to those of adenoma. 5) The positive rate of CEA or EMA in the neighbouring mucosa of adenoma was not different compared with those in the neighbouring mucosa of adenocarcinoma. With the above results, it is concluded that adenoma and adenocarcinoma of the stomach may be different each other, biologically, and further more, it is presumable that adenoma may not be a premalignant lesions. It is considered that examination of CEA immunoreactivity may be helpful in differentiated of adenoma from well-differentiated adenocarcinoma, in most cases.
Adenocarcinoma ; Adenoma

From March 1987 to July 1989, six patients (five dadults and one child) with lung abscess (size, 5-13cm in diameter) were treated with percutaneous aspiration and drainage. In each case, the puncture was made where the wall of the abscess was in contact with the pleural surface. An 8 to 10 Fr catheter was inserted for drainage. Five of 6 had a dramatic clinical response within 24 hours of the drainage. Percutaneous drainage was successful with complete abscess resolution in four and partial resolution in one patient. No response was seen in the rest one. The duration of drainage ranged from 7 to 18 days (average, 15.5days) in successful cases. One case of the failure in drainage was due to persistent aspiration of the neurologically impaired patient. In one patient, the abscess resolved after drainage but recurred after inadvertent removal of the catheter 7 days after insertion. In two patients, concurrent pleural empyema was resolved completely by the drainage. Computed tomography provided anatomic details necessary for choosing the puncture site and avoiding a puncture of the lung parenchyma. Percutaneous catheter drainage is a safe and effective method for treating patients with lung abscess.
Abscess ; Catheters* ; Drainage* ; Empyema, Pleural ; Humans ; Lung Abscess* ; Lung* ; Methods ; Punctures

PURPOSE: This study was conducted to identify job experiences of male hospital nurses. METHODS: Data were collected from 20 male nurses working at general hospitals, through semi-structured in-depth interviews. The interviews were recorded and subsequently transcribed verbatim. Using content analysis, data were coded and categorized. RESULTS: The analyzed domains were motivations for choosing nursing, occupational experiences (3 subdomains), and attitudes toward the future. A total of 85 significant statements were selected from the data and classified into 32 categories. The nurses' motivations for choosing nursing were advantages of employment, their aptitude, scarcity value of men, professionalism and job security, good promotion, stable income, and family influence. In occupational experiences, they were assigned to special fields and dissatisfied with vertical relationship, promotion system, their salary, and gaps in military service time; they had difficulties in adapting to female-dominated groups and encountered gender role stereotype and preconception; they were satisfied with their distinguished performance, but had damaged self-esteem, and were stressed and disappointed in their work. In their attitudes toward the future, they considered their career changes, but tried to make professional and personal advancement. CONCLUSION: These findings have implications for recruiting and retaining male nurses in clinical settings.
Aptitude ; Employment ; Gender Identity ; Hospitals, General ; Humans ; Male ; Military Personnel ; Motivation ; Nurses, Male ; Salaries and Fringe Benefits ; Statistics as Topic

The degree and completion of the fibrovascular ingrowth into the implant were evaluated by magnetic resonance imaging on twenty-one cases of intraorbital hydroxyapatite implant insertion following evisceration (16 cases), enucleation (3 cases), and secondary implantation (2 cases) operated at the Department of Ophthalmology, Yeungnam University Hospital during the period from April 1993 through June 1995. Six to seven microholes were made into the hydroxyapatite sphere. It was inserted into the orbital cavity without wrapping with the preserved sclera during the enucleation procedure and posterior scleral incision was performed for insertion of the implant in the evisceration procedure. The magnetic resonance imaging was first taken 2 months postoperatively and then a month interval by the time of complete fibrovascularization. The range of complete fibrovascularization time varied from 86 to 203 postoperative days. The mean time was 4.48 months which was significantly faster than that of the other authors reported in the literatures. The complete fibrovascularization time of the implant had no significant relation to the preoperative conditions, the age, the surgical procedures and the sizes of the implant.
Durapatite* ; Magnetic Resonance Imaging* ; Ophthalmology ; Orbit* ; Sclera

No abstract available.
Child* ; Humans ; Hypercalciuria*

Carcinoid is a tumor that primarily affects the intestinal tract, which arises from entero-chromaffin cells. Rectal carcinoid tumor is a relatively rare neoplasm originated in Kul-chitszky cell and clinicians have the difficulties in predicting their malignant potential and in proper treatment. These cells are found to increase in the distal small intestine, are common in the appendix, and then decrease within the mucosa of the colon from cecum to rectum. In the cumulative world literature, the incidence of carcinoids of rectum is slightly higher than 10 percent. All of these tumors are within reach of the rigid procto-sigmoidoscope, most being located between 4 and 13 cm from the anal verge. Eighty five percent are found on the anterior and lateral walls. The tumors are usually submucosal and light yellowish or reddish color. The vast majority of rectal carcinoid tumors are be-nign, which can be treated by local excision safely. Lesions larger than 2 cm and invading the muscular wall of the rectum should be considered malignant, which are treated by more radical surgery such as abdominoperitoneal resection. We experienced a case of rectal carcinoid tumor, which was excised by endoscopic polypectomy, so we present this case with a review of relevant literatures.
Appendix ; Carcinoid Tumor* ; Cecum ; Colon ; Incidence ; Intestine, Small ; Mucous Membrane ; Rectum

BACKGROUND: Previous reports have suggested that alleles at the plasminogen activator inhibitor-1 (PAI-1) gene are associated with increased risk of developing coronary artery disease, including myocardial infarction and stroke through their effect on PAI-1 levels. Method: We attempted to search English literatures for all reports of possible effects of PAI-1 gene on cardiovascular disease in human published prior to November 1998. We used a Mantel-Haenszel method (fixed effect model) and random effect model, respectively, to perform a meta-analysis of 7 case-control studies that provided information related to the effects of PAI-1 gene on risk of cardiovascular disease. RESULTS: From 7 studies for diagnosed cardiovascular disease, the relative frequencies of the three genotypes among controls was (5G/5G) (homozygous normal), 24.5%; (4G/5G) (heterozygous), 48.2%, and (4G/4G) (homozygous for the mutant, 675 GGGG), 27.3%. These relative frequencies in cases were 21.7% for 5G/5G, 48.0% for 4G/5G, and 30.3% for 4G/4G. In fixed effect model, compared with those with genotype (5G/5G), the overall odds ratio (OR) for cardiovascular disease among those with (4G/5G) was 1.12 (95% CI, 0.93 to 1.34), and it was 1.20 (1.01 to 1.44) for the (4G/4G) genotype. For five studies with myocardial infarction as the outcome, the overall OR of myocardial infarction was 1.20 (0.99 to 1.47) for those with (4G/5G) and 1.24 (1.00, 1.54) for those with (4G/4G) genotypes, respectively. CONCLUSION: Our findings provide support for the weak association between PAI-1 gene and cardiovascular disease, in particular, myocardial infarction.
Alleles ; Cardiovascular Diseases* ; Case-Control Studies* ; Coronary Artery Disease ; Genotype ; Humans ; Myocardial Infarction ; Odds Ratio ; Plasminogen Activator Inhibitor 1* ; Plasminogen Activators ; Polymorphism, Genetic* ; Stroke

In order to evaluate the possible roles of secretory proteases in the pathogenesis of amoebic keratitis, we purified and characterized a serine protease secreted by Acanthamoeba lugdunensis KA/E2, isolated from a Korean keratitis patient. The ammonium sulfate-precipitated culture supernatant of the isolate was purified by sequential chromatography on CM-Sepharose, Sephacryl S-200, and mono Q-anion exchange column. The purified 33 kDa protease had a pH optimum of 8.5 and a temperature optimum of 55 degrees C. Phenylmethylsulfonylfluoride and 4- (2- Aminoethyl) -benzenesulfonyl-fluoride, both serine protease specific inhibitors, inhibited almost completely the activity of the 33 kDa protease whereas other classes of inhibitors did not affect its activity. The 33 kDa enzyme degraded various extracellular matrix proteins and serum proteins. Our results strongly suggest that the 33 kDa serine protease secreted from this keratopathogenic Acanthamoeba play important roles in the pathogenesis of amoebic keratitis, such as in corneal tissue invasion, immune evasion and nutrient uptake.
Acanthamoeba/*enzymology/isolation & purification/pathogenicity ; Acanthamoeba Keratitis/*parasitology ; Animals ; Cornea/parasitology ; Humans ; Hydrogen-Ion Concentration ; Korea ; Serine Endopeptidases/chemistry/*isolation & purification/*metabolism ; Substrate Specificity ; Temperature ; Virulence Factors