1.A Case of Reiter's Syndrome.
Tae Kyung LEE ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1986;24(1):112-117
We presented a case of Reiters syndrome consisting of conjunctivitis, arthritis, and skin lesions, occurring in 20-year-o1d male. He had neither an episode of dysentery nor a history of sexual exposure before onset of syndrome. The skin lesions had begun with erythernatous scaly patches on the inguinal region and scalp, and later followed by generalized pustular, psoriasiform and/or hyperkeratotic crusted lesions on the erythematous base. Yellowish discoloration and onycholysis of nails and shallow ulcer of glans penis were observed. Arthritis of the knee and shoulder joints were developed, accompanied by pain, swelling, limited motion, wasting and weakness of both lower extremities. In laboratory investigation, urinalysis, stool examination for parasites and occult blood, renal function test, blood VDRL, and X-ray of chest, both knee. joints, shoulder joint and thoracolumbar spine were within normal limit or negative except for leukocytosis(24, 500/mm), increased ESR(90 mm/hr) and hypoalbuminemia(2.6 g/dl), and he was associated with HLA-A3, A 9, B5, and Rw 49 Histopathologically skin biopsy specimen showed extensive hyperkeratosis, paralceratosis, elongated rete ridges, spongiform macropustule of Kogoj. He was treated effectively with antibiotics, corticosteroid, and methotrexate for two months without recurrence till now.
Anti-Bacterial Agents
;
Arthritis
;
Biopsy
;
Conjunctivitis
;
Dysentery
;
Hematologic Tests
;
HLA-A3 Antigen
;
Humans
;
Joints
;
Knee
;
Lower Extremity
;
Male
;
Methotrexate
;
Occult Blood
;
Onycholysis
;
Parasites
;
Penis
;
Recurrence
;
Scalp
;
Shoulder Joint
;
Skin
;
Spine
;
Thorax
;
Ulcer
;
Urinalysis
2.A Case of Keratosis Punctata of the Palmar Greses.
Jang Soo LEE ; Kyung Sool KWON ; Tae An CHUNG
Korean Journal of Dermatology 1981;19(3):325-329
Keratosis punctata of palmar creases has been considered an uncommon variant of keratosis punctata, which itself is considered rare condition. Clinically our case, 32-year-old seaman, shows cup-shaped depression of the epidermis of varying size, from 1-3mrn in diameter, limited to the large flexor creases of the palms and digit. The histologic features are hyperkeratotic and slight acanthotic central epidermal depression without parakeratosis and loss of granular layer. A sparse mononuclear infilterate are seen arround the capillaries in the dermal papillas. No relationship to arsenical agents, syphilis, or genetic factors can be ascertained by history.
Adult
;
Capillaries
;
Depression
;
Epidermis
;
Humans
;
Keratosis*
;
Parakeratosis
;
Syphilis
3.A Case of Generalized Lichen Nitidus.
Kyung LEE ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1987;25(5):633-636
A 6-year-old boy presented in December 1986 with a 1-year history of a nonpruritic flesh-colored papular eruption that began on the dorsum of left hand and gradually appeared on other areas, such as upper and lower extremities, trunk and external genitalia. Complete blood cell count. urinalysis, VDRL, stool examination, liver function test and chest X-ray were negative or within normal limits. On physical examination, he had uniform, pinhead-sized, flat-topped, shiny, discrete paples on the whole body surface. No oral lesions were found. Histopathologically skin biopsy specimen showed a circumscribed nest of infiltrate consisted of lymphocvtes, histiocytes and a few epitheloid cells. The cell nest was separated from the overlying flattened epidermis by a large space. Direct immunofluorescent test was negative. He had been treated with systemic corticosteroid for two months without recurrence until nowadays.
Biopsy
;
Blood Cell Count
;
Child
;
Epidermis
;
Genitalia
;
Hand
;
Histiocytes
;
Humans
;
Lichen Nitidus*
;
Lichens*
;
Liver Function Tests
;
Lower Extremity
;
Male
;
Physical Examination
;
Recurrence
;
Skin
;
Thorax
;
Urinalysis
4.A Case of Mycosis Fungoides.
Kyung Sool KWON ; Tae Kyung LEE ; Jin Gwon KIM ; Tae Ahn CHUNG ; Tetszi MITSUI
Korean Journal of Dermatology 1986;24(5):726-733
We present a case of mycosis fungoides of an 52-year-old woman who showed multiple pruritic erythematous papules, plaques with ulcers on the trunk, extremities and face. Her skin biopsy specimens were studied irnmunohistochemically with, monoclonal antibodies against T cells(80%, Leu-4, OKT11), T-cell subsets (60% Leu-3a, OKT4a, 40% OKT8) and Langerhans cell(OKT6). We think that this case should be considered in the differential diagnosis of adult T-cell leukemia/lymphoma. The proliferating cells were negative for anti-Tac.
Adult
;
Antibodies, Monoclonal
;
Biopsy
;
Diagnosis, Differential
;
Extremities
;
Female
;
Humans
;
Middle Aged
;
Mycosis Fungoides*
;
Skin
;
T-Lymphocyte Subsets
;
T-Lymphocytes
;
Ulcer
5.A Case of Segmental Neurofibromatosis.
Tae Kyung LEE ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1987;25(5):696-699
A 61-year-old female had neurofibromas situated on the right side of upper trunk, shoulder and neck in the distribution of dermatomes C3 and C4(right), which developed 3 years ago. There were not cafe-au-lait spots, axillary frecklings, or Lisch nodule (iris pignented hamartoma). Biopsy specimen showed collagenous wavy fibrils among which spindle-shaped and round cells were embedded as seen in the typical neurofibroma. This case was considered to be a segmental form of von Recklinghausen's disease.
Biopsy
;
Cafe-au-Lait Spots
;
Collagen
;
Female
;
Humans
;
Middle Aged
;
Neck
;
Neurofibroma
;
Neurofibromatoses*
;
Neurofibromatosis 1
;
Shoulder
6.The significance of lectins in the differentiation between lichen sclerosus et atrophicus(LSA)and scleroderma.
Joon Ho LEE ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1993;31(3):329-336
BACKGROUND: Differential diagnosis of lichen sclerosus et atrophicus( SA) and scleroderma is occasionally difficult. OBJECTIVE: The purpose of this study was to attempt differentiation between the two diseases using imrnunohistochemical stain and lectins. MEHTODS: Paraffin-embeddred sections of 4 cases of LSA and 11 cases of scleroderma were evaluated for this study. Using lectins, such as peanut agglutinin(PNA), siybean agglutinin(SBA), Ulex europaeus agglutinin-I(UEA-I) and Dolichos biflorus agglutinin(DBA) and the avidin-biotin-peroxi-dase complex(ABC) technique, differential lectin binding patterns betv een the two diseases were examined. RESULTS: In the case of LSA, PNA and SBA stained the upper and lower spinous layer of the epidermis, and UEA I also stained the spinous layer of the epidermis weakly, but no DBA was stained. In the case of scleroderma, PNA stained not only the spinous layer but also the basal layer, SBA stained the upper half of the spinous layer but not the lower half of the pinous layer of epidermis. But UEA-I stained the vascular endothelial cells of dermis instead of epidermis, and DBA stained only the basal layer of epidermis. CONCLUSION: Staining of these 4 lectins on paraffin-embedded sectians using ABC teehnique could be helpful in differenting LSA and scleroderma.
Dermis
;
Diagnosis, Differential
;
Dolichos
;
Endothelial Cells
;
Epidermis
;
Lectins*
;
Lichen Sclerosus et Atrophicus*
;
Lichens*
;
Ulex
7.A Case of Woringer Kolopp Disease Treated with Topical PUVA.
Jae Bong LEE ; Ho Sun JANG ; Chang Keun OH ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1999;37(2):239-243
A 26-year-old Korean man had an erythematous scaly plaque on his right thigh for fifteen years. He was diagnosed with chronic eczema and treated with topical steroid, but no clinical improvement was obtained for 15 years. Laboratory studies including complete blood cell count, urinalysis, liver and renal function test, and peripheral blood smear were normal. A biopsy specimen showed hyperkeratosis, acanthosis, and mononuclear cellular infiltration in the epidermis. These cells had a perinuclear halo and showed a Pautrier's microabscess like configuration. In the dermis, there was a band like infiltration of inflammatory cells. Infiltrates of the epidermis were negative for leukocyte common antigen(CD45) and positive for Pan T cell(CD45RO). He was treated with topical PUVA twice a week for twelve weeks. Clinical and pathological improvements were obtained. We propose PUVA may be a useful therapeutic modality to treat Woringer Kolopp disease.
Adult
;
Biopsy
;
Blood Cell Count
;
Dermis
;
Eczema
;
Epidermis
;
Humans
;
Leukocytes
;
Liver
;
Pagetoid Reticulosis*
;
Thigh
;
Urinalysis
8.A Case of Generalized Annular Lichen Planus Controlled by Erythromycin.
Jae Bong LEE ; Hang Gye SHIN ; Ho Sun JANG ; Kyung Sool KOWN ; Tae Ahn CHUNG
Korean Journal of Dermatology 1997;35(2):307-311
A 69-year-old man presented with annular lichen planus involving both forearms, hand dorsa, wrists, inner sides of the thighs, knees and ankles. He was treated initially with systemic corticosteroids and etretinate, but rernission and recurr ence of the skin lesions were observed. During the follow-up, we found erythrasma on all his toewebs and both soles. After administration of erythromycin for the treatment of erythrasma, lesions of the lichen planus rapidly improved. Five months later, some lesions of lihen planus and erythrasma had recurred. After administration of erythromycin, the lesions of lichen planus improved again. No recurrence was observed for the following 8 months. We suspect that eradication of the chronic focus of infection and the anti-inflammatory effect, of erythromycin may lead to supression of abnormal immunological reactions and resolution of lichen planus.
Acitretin
;
Adrenal Cortex Hormones
;
Aged
;
Ankle
;
Erythrasma
;
Erythromycin*
;
Etretinate
;
Follow-Up Studies
;
Forearm
;
Hand
;
Humans
;
Knee
;
Lichen Planus*
;
Lichens*
;
Recurrence
;
Skin
;
Thigh
;
Wrist
9.A case of mycobacterium fortuitum infection at the site for antibiotics susceptibility test.
Joon Ho LEE ; Doo Chan MOON ; Kyung Sool KWON ; Tae Han CHUNG
Korean Journal of Dermatology 1993;31(5):769-774
Cutaneous mycobacterial infection can occur with Mycobacterium tube culosis or other mycobacterial agents. The commonest of the group IV rapidly growing mycobacteia Mycobacterium fortuitum, has widespread distribution in natur, and is an uncommon causative agent of human mycobacterial infection. We report herein a case of Mycobacterium fortuitum infection follcwiiig an antibiotics susceptibility test. This 24-year-old man suffered fram ulcerative itchy nodules on the left forearm where the antibiotics susceptibility test was don. The skin biopsy specimen revealedly. iphohistiocytic granulomatous infiltration in the dermis. Culture of the tissue specimen revealed rapicly growing yellowish colonies, which was isolated to Mycobacoterium fortuitum. Among 3 biovariants of M. fortuitum, our case was revealed to he biovariant fortuiiam: Surgical excision was performed followed by the administration of antiliiiitics, and no sign of relapse was noted until now, 1 year since.
Anti-Bacterial Agents*
;
Biopsy
;
Dermis
;
Forearm
;
Humans
;
Mycobacterium fortuitum*
;
Mycobacterium*
;
Recurrence
;
Skin
;
Ulcer
;
Young Adult
10.A Case of Multiple Endocrine Neoplasia type 3 With Multiple Mucosal Neuroma.
Chea Wook LEE ; Chang Keun OH ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1999;37(4):505-509
Multiple endocrine neoplasi~a type 3 is a rare, heritable or sporadic, multiple neoplastic disorder that is charracterized by thyroid medullary careinoma, pheochromocytoma, multiple mucosal neuroma, and marfanoid habitus. The most important disorder of the syndrome is mucosal neuroma that is an early diagnostic sign of multiple endocrine neoplasia type 3. Early diagnosis of MEN type 3 determines prognosis of the disease. We present a case of multiple endocrine neoplasia type 3 of the sporadic pattern in a 27-year-old man who had typical medullary thyroid carcinoma, mucosal neuroma, marfanoid habitus, and megacolon.
Adult
;
Early Diagnosis
;
Humans
;
Male
;
Megacolon
;
Multiple Endocrine Neoplasia*
;
Neuroma*
;
Pheochromocytoma
;
Prognosis
;
Thyroid Gland
;
Thyroid Neoplasms