A patient with keratoma hereditaria mutians, 20 years old Korean girl, presented the following classic features of this rare disease, palmar and plantar hyperkeratosis beginning early in life, starfishlike keratosis of the dorsa of the hands, hyperkeratotic patches of dorsa of the feet with thickening of the toe nails, keloid-like keratoma of the elbows and knees, and constriction of the all fingers begining in early life and spontaneous amputation of theleft 5th finger. No family history was demonstrated in this patient.
Amputation ; Constriction ; Elbow ; Female ; Fingers ; Foot ; Hand ; Humans ; Keratosis* ; Knee ; Rare Diseases ; Toes ; Young Adult

This study was performed with 31 cases of cutaneous tuberculosis among 18,846 cases of out-patients in Dermatologic Department of Busan National Universicy Hospital from 1967 to 1976. These 31 cases were consistent with skin tuberculosis in histological and clinical findings. The results were as follows. 1. The incidence of skin tuberculosis is 0.16%, among 18,846 cases of outpatients, 2. The localized tuberculosis of the skin, i.e. lupes vulgaris, tuberculosis verrucosa cutia and scrofuloderma was more common than disseminated type of tuberculosis of the skin. Among the disseminated types, papulonecrotic tuberculid is rather common than other types. 3. The ratio between male and female was l. 2: 1. 4. The age of onset varied according to types, but 70% of all cases occurred in the age group between 10-30 years. 5. Lung tuberculosis was associated in abaut 20 of skin tuberculosis. 6. Tubercle and tuberculoid structure were noticed in all biopsy specimens ancl in 55% the caseation necrosis was noticed.
Age of Onset ; Biopsy ; Busan ; Female ; Humans ; Incidence ; Lung ; Male ; Necrosis ; Outpatients ; Skin* ; Tuberculosis ; Tuberculosis, Cutaneous*

We reported a case of follicular mucinosis which occurred in a 51 year old m;', . He had a firm grouped folliculopapular plaque above left eyebrow with ill-defined border, without any loss of eyebrow. But histopathologic findings showed charac- teristic changes in hair follicles and sebaceous glands with mucinous degeneration and no evidence of suggesting mycosis fungoides. Relatively rapid response to systemic corticosteroid suggested that this therapy had an actual effect.
Eyebrows ; Hair Follicle ; Humans ; Middle Aged ; Mucinosis, Follicular ; Mucins ; Mycosis Fungoides ; Sebaceous Glands

We presented a case of Reiters syndrome consisting of conjunctivitis, arthritis, and skin lesions, occurring in 20-year-o1d male. He had neither an episode of dysentery nor a history of sexual exposure before onset of syndrome. The skin lesions had begun with erythernatous scaly patches on the inguinal region and scalp, and later followed by generalized pustular, psoriasiform and/or hyperkeratotic crusted lesions on the erythematous base. Yellowish discoloration and onycholysis of nails and shallow ulcer of glans penis were observed. Arthritis of the knee and shoulder joints were developed, accompanied by pain, swelling, limited motion, wasting and weakness of both lower extremities. In laboratory investigation, urinalysis, stool examination for parasites and occult blood, renal function test, blood VDRL, and X-ray of chest, both knee. joints, shoulder joint and thoracolumbar spine were within normal limit or negative except for leukocytosis(24, 500/mm), increased ESR(90 mm/hr) and hypoalbuminemia(2.6 g/dl), and he was associated with HLA-A3, A 9, B5, and Rw 49 Histopathologically skin biopsy specimen showed extensive hyperkeratosis, paralceratosis, elongated rete ridges, spongiform macropustule of Kogoj. He was treated effectively with antibiotics, corticosteroid, and methotrexate for two months without recurrence till now.
Anti-Bacterial Agents ; Arthritis ; Biopsy ; Conjunctivitis ; Dysentery ; Hematologic Tests ; HLA-A3 Antigen ; Humans ; Joints ; Knee ; Lower Extremity ; Male ; Methotrexate ; Occult Blood ; Onycholysis ; Parasites ; Penis ; Recurrence ; Scalp ; Shoulder Joint ; Skin ; Spine ; Thorax ; Ulcer ; Urinalysis

The authors aimed to apply a nonsurgioal and atraumatic method for avulsing dystrophic nails due to onyohomyoosis by using 22.25% urea ointment under occlusive dressing. One hundred and eighty-nine nails with onychomycosis in fifty-five patients were treated by this rnethod. The results obtained a,re as follows: 1. Of a total of 82 fingernails and 107 toenails in 55 patients, all fingernails and 103 toenails showed an excellent response with easy removal of the diseased nails. 2. The duration tha.t the occluded urea ointment remained in place before sucessful avulsion was 6.7(range, 3 to 18) days for fingernails, and 9.1(range, 3 to 18) days for toenails with onychomycosis. 3. Of 4 nails of control group which were treated with white petrolatum, none showed the significant improvernent. 4. The problems during this treatment were; severe irritation with pain(l case), mild irzitation and/or itching(5 cases), and pin-point bleeding on curettage of nail bed (19 cases). It is suggested the urea treatment has many advantages and seemed to be ideal for patients with digital vascular insufficiency and increased susceptibility to infection.
Curettage ; Hemorrhage ; Humans ; Nails ; Occlusive Dressings ; Onychomycosis* ; Petrolatum ; Urea*

No abstract available.
Cryptococcosis*

The effect of 50 per cent potassium iodide (KI) ointment with occlusive dressing on onychomycosis of the fingers and toes was studiei in 54 patients with 176 diseased nails. The results obtained were as follows. 1. Of a total of 76 fingernails and 100 toenails in 54 patients, all fingernails and toenails showed an excellent response with easy removal of the diseased nails. 2. The duration that the occluded KI aintment remained in place before successful avulsion was 6. 6 (range, 3 to 18) days for fingernails, and 6. 8 (range, 3 to 20) days for toenails with onychomycosis. 8. Of 16 nails of control group which were treated with vaseline, none showed the significant improvement. 4. The problems during this treatment were; mild irritation and/or itching (9 cases), and pin-point bleeding on curettage of nail bed (18 cases). It is suggested that the KI treatment has many advantages and seemed to be an ideal method of treatment of onychomycosis.
Curettage ; Fingers ; Hemorrhage ; Humans ; Nails ; Occlusive Dressings ; Onychomycosis* ; Petrolatum ; Potassium Iodide* ; Potassium* ; Pruritus ; Toes

BACKGROUND: Trichloroacetic acid chemexfoliation has gained popularity and is widely used cosmetically. The depth of the wound caused by the various dilutions of TCA is paramount to the therapeutic efficacy. Therfore rational use of TCA chemexfoliation requires a clear understanding of the expected depth of destruction caused by a given dilution. OBJECTIVE: The purpose of this stuely is to quantitate the wound deptlw produced by varying concentrations of TCA. We have stirdied takie effects of consecutive applications, occlusion and tretinoin pretreatment on wound depth in TCA clinimical peeling. METHODS: Various concentrations of TCA and distilled water were aplied to two pairs of test sites of a guinea pigs back in a uniform fashion with cotton-tip applicators and then we have measured the mean depth of epidermal necrtsis mieroscopically by using Visual Imagc Data Analysis System. RESULTS: 1. Depths of wounds createdly threre consecutive applications of 20, 35% and 50% TCA were deeper than those of wounds by a single application of TCA. 2. Depths of wounds created by application of TCA with the occlusive method were deeper than those of the open method. Therefore the effect of occlusion is to enhance the penetration of TCA. 3. Depths of wounds pretreatwi with 0.05 % tretinoin daily for 7 days are deeper than those of the control in 50% TCA chemical peeling. Therefore the effect of 0.05% retinoin pretreatment is to enhance the penetration of TCA. CONCLUSION: This study showed that consecutive applications, oeclusion and tretinoin pretreatment in TCA chemexfoliation enhance the peietration of TCA.
Animals ; Chemexfoliation* ; Guinea Pigs ; Statistics as Topic ; Tretinoin ; Trichloroacetic Acid* ; Water ; Wounds and Injuries

We present a case of bullous congenital ichthyosiform erythroderma in a two year old female, in whom no hereditary background was found. The skin lesion was characterized clinically by blister formation with generalized erythematous hyperkeratosis which was especially prominent on the flexural surfaces of extremities and intertriginous areas. The histopathologic examination revealed marked hyperkeratosis, cavity changes of the malpighian cells with perinuclear vacuoles and markedly thickened granular layer containing many keratohyaline granules.
Blister ; Extremities ; Female ; Humans ; Hyperkeratosis, Epidermolytic* ; Skin ; Vacuoles

Human sparganosis is not uncommon and over 60 cases are reported in Korea but the case infested with multiple spargana is rare. The case we are reporting here is a 33 year-old Korean male having had an abscess and several bean-sized nodules on the left thigh. The patient had the history of eating frogs as a tonic food 3 years ago. Five spargana were removed from the lesions by surgical excision. Two of them were alive and other three were degenerated or calcified.
Abscess ; Adult ; Eating ; Humans ; Korea ; Male ; Scabies* ; Sparganosis ; Thigh