Herpes zoster is a acute viral infection of nerve structures manifesting cutaneous lesions in the form of groups of vesicles distributed along one or more peripheral sensory nerves. Sometimes involve motor nerves. The skin lesions usually appear on unilateral, but some on bilateral. And caused by variella-zoster virus, which is the same virus, with varicella. The most important etiologic mechanism is the reactivation of the latent virus; a latent virus infection is set up in spinal and cranial sensory ganglion as a result of hematogenous dissemination during the initial varicella infection and is activated in later life so that the virus spread down to the peripheral nerve into the skin. Durig last 5 years (1968-1972) 94 cases of Herpes zoster, of Dermatology Dept. in N.M.C. were investigated by statistics of sex, age, predilection site of skin eruptions, seasonal variation, and of its complications or associated diseases. The reults were following; In sex, age distribution, female is rather common than male and more commonly affected after 40's. In predilection site, more than half cases, involved thoracic cutaneous nerves, and the least were sacral and lateral cutaneous nerves. Right and left side proportion was about same (40: 49), bilateral or mid-zone involvement were 5 cases. In seasonal distribution, there was no relation between epidemic of varicella and Herpes zoster, The most were at Summer, and the least at Autumn. In complications and associated diseases, complication noted in 4 cases, 3 were Herpes zoster ophthalmicus and 1 case was Ramsey-Hunt syndrome. The most frequent associating disease was pulmonary tuberculosis, otherwise were diabetes, asthma etc.
Age Distribution ; Asthma ; Chickenpox ; Dermatology ; Female ; Ganglia, Sensory ; Herpes Zoster Ophthalmicus ; Herpes Zoster* ; Humans ; Male ; Peripheral Nerves ; Seasons ; Skin ; Tuberculosis, Pulmonary

Synovectomy of the knee in rheumatoid arthritis has been recommended as an effective procedure which improved symptoms such as pain, swelling, and limitation of motion. But some problems, such as limitation of range of motion, infection, long hospital days, occured in open synovectomy. Arthroscopic synovectomy yields reliable result compatible to open synovectomy with less invasiveness and postoperative morbidity. The authors analyzed 20 knees of 14 patients who has done synovectomy of knee in Kyung Hee University Hospital from September 1989 to October 1992. Of the 14 patients, thirteen were females and only one was male, ten knees were affected on the right and ten on the left respectively. Five knees were operated as open synovectomy and fifteen knees as arthroscopic synovectomy. In six patients, both knees were operated either open or arthroscopic synovectomies. The preoperative diagnosis of 20 knees were rheumatoid arthritis as clinically, serologically and radiologically, 13 knees are confirmed as pathologically. Average hospital days after operation were 19 days in open synevectomy and 11 days in arthroscopic synovectomy. Average operation time were 72 minutes in open synovectomy and 84 minutes in arthroscopic synovectomy. No complication occured as a result of these synovectomies. After average follow up of 19 monthes, 1 knee from 5 knees in open synovectomy and 3 knees from 15 knees in arthroscopic synovectomy had pain and intermittent swelling as postoperatively. And only 1 knee in open synovectomy had loss of range of motion. No other patients lost motion in their knees. Preoperatively 17 knees showed radiographic change of rheumatoid arthritis and 16 knees showed no progressive radiographic deterioration at final follow up. And patients overall showed a significiantly increased functional status postoperatively. In conclusion, the result obtained after arthroscopic synovectomy are comparable with those obtained after open synovectomy. In addition arthroscopic procedure had lessened postoperative morbidity as loss of range of motion, postoperative infection, long hospital days and useful as palliative surgery in advanced rheumatoid arthritis.
Arthritis, Rheumatoid ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Knee ; Male ; Palliative Care ; Range of Motion, Articular

BACKGROUND: Extended-spectrum beta-lactamase-producing (ESBL) Klebsiella pneumoniae is an important cause of nosocomial infections in neonatal intensive care units (NICUs). This study aimed to reduce ESBL-producing K. pneumoniae in the NICU by using infection control measures. METHODS: We performed prospective surveillance cultures, monitoring, and education for infection control in the NICU between May and August 2011. Specimens were collected from all infants and the environment including stethoscopes, thermometers, ventilators, incubators, etc. The anterior nares and hands of healthcare workers were also screened. We inspected infection control practices and provided feedback. The level of infection control awareness was measured using a questionnaire. RESULTS: The level of awareness and performance of hand washing increased significantly after intervention (both P<0.001). The environmental management of healthcare providers also improved significantly (P=0.001). The yield of ESBL-producing K. pneumoniae from clinical specimens decreased gradually throughout the study period (30.4% in May to 12.6% in August). Central catheter-related K. pneumoniae bacteremia decreased from 1.3/1000 to 0/1000 catheter-days. CONCLUSION: Infection control measures including education, monitoring, and surveillance can lower the incidence of ESBL-producing K. pneumoniae in the NICU.
Bacteremia ; beta-Lactamases ; Cross Infection ; Delivery of Health Care ; Hand ; Hand Disinfection ; Health Personnel ; Humans ; Incidence ; Incubators ; Infant ; Infant, Newborn ; Infection Control ; Intensive Care Units ; Intensive Care Units, Neonatal ; Intensive Care, Neonatal ; Klebsiella ; Klebsiella pneumoniae ; Pneumonia ; Prospective Studies ; Stethoscopes ; Thermometers ; Ventilators, Mechanical

Pityriasis Circinata is a rare, symptomless, etiologically uncertain disease, but often associated with chronic illness such as Tuberculosis, diseases of uterus and ovaries. It was first described- in Japan by Toyama(1906), Matsura(1906), then reported in South Africa, France, England, Germany, and North-Africa. However, much more frequent evidence noted in Far East. Many authers agree that this condition is a specific localized type of acquired ichthyosis. This disease is manifested by strictly round scaly, light or dark brownish ichthyotic patches of variable number and diameter. Mainly distributed on trunk, and extremities with freedom of flexure. And having history of winter exacerbation and summer remission. These two cases of pityriasis Circinata are, although Toyama quoted 4 Korean patients reports and 2 cases of Manchuria, the first report in Korea, which have been associated with tuberculous empyema and meningitis, respectively.
China ; Chronic Disease ; Empyema, Tuberculous ; England ; Extremities ; Far East ; Female ; France ; Freedom ; Germany ; Humans ; Ichthyosis ; Japan ; Korea ; Meningitis ; Ovary ; Pityriasis* ; South Africa ; Tuberculosis ; Uterus

Porokeratosis (mibelli's disease) is a chronic, heritable disorder of the skin, which has a regular dominant limitation to the male sex. This is characterized by localized areas of faulty keratinization resulting in the cornoid lamella, the morphologic and histologic hallmakr of the disease process. Histogenesis is best explained as a mutant clonal keratosis of epidermis, these clonal cells are probably ingerited. A case of porokeratosis Mibelli is reported with its clinical, histological evaluation and review of articles.
Epidermis ; Humans ; Keratosis ; Male ; Porokeratosis* ; Skin

Soft tissue coverage of heel defects has long been a difficult problem. In 1982, Iron reported eight cases of heel defects in children using an ipsilateral posterior thigh flap with use of the Hoff-man's skeletal fixation apparatus for immobilization. We report three cases of heel defects treatment in children using ipsilateral posterior thigh flap and detach flap in an average 13 days with aid of single photon emission computed tomography(SPECT) for evaluation of circulation status of flap.
Child ; Fracture Fixation ; Heel ; Humans ; Immobilization ; Iron ; Thigh ; Tomography, Emission-Computed, Single-Photon

This study was performed to investigate the effect of endotoxin to the CCl4-induced liver injury. Twelve Sprague-Dawley rats were intraperitoneally injected 1.6 g/kg CCl4 as control group. Another 24 rats were orally administrated 300 mg/kg of neomycin at 16 and 3 hours prior to CCl4 injection as experimental group. Twelve among them were intraperitoneally infected 1.0 mg/kg of endotoxin(E-Coli, 0111:B4, No L-2630, lipopolysaccharide, Sigma, USA) and CCl4 simultaneously for offsetting neomycin effect. The rats were sacrificed at 1, 4, 10, and 24 hours after CCl4 injection. The liver tissues from all experimental groups were observed by light and electron microscopy. The results obtained were summarized as follows: In the CCl4 only group, the hepatocytes revealed sweling of ER and mitochondria with many lipid droplet in the cytoplasm. Focal cellular necrosis was seen at the later phase. The Kupffer cells were activated and showed many cytoplasmic processes, secondary lysosomes, and vaculoles. The endothelial cells were edematous. Several neutrophils, platelets, and microthrombi were scattered in the sinusoid. In the neomycin-CCl4-endotoxin administrated group, both hepatocytic destruction and intrasinusoidal microthrombi formation were more pronounced. In the neomycin pretreated group, the hepatocytes revealed mild cellular destruction without necrosis. There is no intrasinusoidal microthrombi. According to these results, it would be concluded that the small dosage of gastrointestinal tract-derived endotoxin affects to the liver injury caused by CCl4. The synergistic effects of CCl4 and gastrointestinal tract-derived endotoxin which can not be detoxified by damaged Kupffer cells, may be more important in the pathogenesis of CCl4-induced liver injury.
Rats ; Animals

Reconstruction of the anophthalmic contracted socket was performed in 28 eyes (34 cases) from October 1981 to February 1985. The follow-up period after surgery ranged from 6 months to 12 months. The age range of the patients was from 5 years to 60 years, and there were 25 males and 3 females. Degree of the contraction and method of the operation were as follows: 1. Mildly contracted socket. Among 12 eyes, 7 eyes were operated with acrylic conformer(AC) after buccal mucous membrane graft(BMMG) and 5 eyes with dental conformer(DC) after buccal mucous membrane graft. 2. Moderately contracted socket. Among 9 eyes, 6 eyes were operated with AC after BMMG and 3 eyes with DC after BMMG. 3. Severely contracted socket. Among 7 eyes, 5 eyes were operated with AC after BMMG and 2 eyes with DC after BMMG. The results were as follows: 1. Etiology of the contracted socket was inflammation(12 eyes: 43%), trauma(7 eyes: 25%), burn(5 eyes: 18%) and irradiation(4 eyes: 14%). 2. In reconstruction of the contracted socket, buccal mucosa was a good substitute for conjunctiva. 3. Better result was obtained in the cases with lesser contraction preoperatively, and in the cases of reconstruction after preoperative repair of lid defect. 4. The optimal interval for further surgery was at least about 6 months due to resolution of the fibroblastic activity. 5. Postoperative complications were noted in 8 cases(24%), which were recontraction in 4 cases(12%), shrinkage of the graft in 2 cases(6%), necrosis of the graft in 1 case(3%), and infection in 1 case(3%). 6. Most patients now wear artificial eyes with or without lightly tinted glasses, giving them good appearance, even though their sight was gone.
Conjunctiva ; Eye, Artificial ; Eyeglasses ; Female ; Fibroblasts ; Follow-Up Studies ; Glass ; Humans ; Male ; Mouth Mucosa ; Mucous Membrane ; Necrosis ; Postoperative Complications ; Transplants

Enlow's counterpart analysis explains the complex with anatomic and developmental characteristics where craniofacial aspect of individuals has been developed. Counterpart analysis does not compare individual measurement with the normal value from the average of majority but analyzes by comparison of values that each individual has. In this study we examined surgical changes in skeletal Class III malocclusion patients(male 40, female 40) and compared them with normal occlusion patients using counterpart analysis. The results indicated that : 1. Skeletal anterior-posterior discrepancy was relieved by shortening of the ramus width(B3). 2. The ramus alignment(R3, R4) was displaced posteriorly and the occlusal plane angle(R5) was rotated clockwise. 3. Skeletal Class III pattern was relieved in the post-operative group, but differences in the level of the cranium(R1, R2) was remaining compared to the normal occlusion patients. 4. In the comparison of surgery methods, the two-jaw surgery group presented changes in the maxillary length(A4), ramus alignment(R3,R4) and occlusal plane angle(R5) compared to the one-jaw surgery group, but the differences were not significant. In the past study about Korean skeletal Class III patients, the skeletal characteristics are upward backward rotation of the cranial base, posterior displacement of the maxilla, forward inclination of the ramus and lengthening of the mandibular body, but in this study, skeletal Class III pattern was relieved by shortening of the ramus width and maxillary advancement by orthognathic surgery, because orthognathic surgery is usually performed on limited areas in the maxilla and the mandible.
Dental Occlusion ; Female ; Humans ; Malocclusion* ; Mandible ; Maxilla ; Orthognathic Surgery ; Reference Values ; Skull Base

The nm23 gene was originally identified from murine melanoma cell lines of varying metastatic potential. A strong association has been observed between reduced expression of nm23 gene and acquisition of metastatic behavior in some tumor cells including breast cancer and melanoma, but not in others such as colon cancer, neuroblastoma, and cervical cancer. It was proposed that nm23 may function as a suppressor gene for tumor metastasis. It has recently been found that the sequence of nm23 and NDP-kinase(NDP-K) was identical. Mortality associated with human breast carcinoma is almost entirely due to subsequent metastasis, but the molecular basis of this metastasis is not understood. Elucidation of the genetic control of metastatic propensity of a tumor is important in determining prognosis and choice of therapy. The purpose of this study was to investigate the relationship of nm23 protein expression with axillary lymph node metastasis and other prognostic factors. Using an immunohistochemical technique and employing a polyclonal antibody to nm23 protein, we have determined nm23 expression in a series of 72 infiltrating ductal carcinomas of the breast. Immunostaining for the nm23 gene product have heterogenous cytoplasmic and nuclear staining in 61 patients(84.7%). Sections were scored according to relative abundance(1 = less than 25% of the cells, 2 = 26-75%, 3 = 76-100%). In 61 patients with positive immunostaining, the staining was scored as 1 in 41.6%, 2 in 18.0%, and 3 in 40.2%. The staining of tumor cells was greater than that in normal epithelial cells and stromal cells. No relationship was found between nm23 expression and lymph node metastasis, histologic grade, tumor size, estrogen receptors or progesterone receptors. Therefore, nm23 protein is increased in neoplastic tissues but no correlation with metastatic potential could be demonstrated. The biological mechanism of over-expression of nm23 in malignant cells and its role in tumor progression remain to be determined.
Breast Neoplasms ; Breast* ; Carcinoma, Ductal* ; Cell Line ; Colonic Neoplasms ; Cytoplasm ; Epithelial Cells ; Genes, Suppressor ; Humans ; Lymph Nodes ; Melanoma ; Mortality ; Neoplasm Metastasis ; Neuroblastoma ; Prognosis ; Receptors, Estrogen ; Receptors, Progesterone ; Stromal Cells ; Uterine Cervical Neoplasms