1.Effect of Clonidine on the Blood Pressure, Heart Rate and Plasma Catecholamine Concentration during General Anesthesia.
Chong Dal CHUNG ; Kyung Joon LIM ; Kwang Soo SONG
Korean Journal of Anesthesiology 1997;33(2):336-341
BACKGROUND: Induction of general anesthesia with tracheal intubation and skin incision are potent stimuli that can induce increased sympathetic activity, heart rate and blood pressure. We compared the hemodynamic response and catecholamine concentration during general anesthesia with intravenous clonidine pretreatment, a centrally acting -2 adrenoceptor agonist, and without pretreatment. METHODS: Forty ASA I or II patients aged from 20 to 60 years undergoing elective surgery were randomly allocated to two groups. In group I, 5 ml of 0.9% normal saline as control administered intravenously 10 minutes before induction of anesthesia, and anesthesia was induced with thiopental sodium, succinylcholine and maintained with N2O (2.5L/min)-O2 (2.5L/min)-enflurane (1.3~1.8 vol%). In group II, 4 g/kg clonidine diluted in 5ml of normal saline administered intravenously 10 minutes before induction of anesthesia, and anesthesia was induced with thiopental sodium, succinylcholine and maintained with N2O-O2-enflurane (0.5~1.0vol%) and 2 g/kg/hr clonidine was continuously infused. We measured blood pressure, heart rate and plasma catecholamine at preinduction, 1 minute after intubation (T1), 1 (T2) and 30 minutes after skin incision (T3) and compared with group I. RESULTS: There was statistical significance in systolic and diastolic pressure at T1 between two groups. There was statistical significance in heart rate, epinephrine and norepinephrine at T1, T2 and T3 between two groups. CONCLUSION: The elevation of blood pressure, heart rate and plasma catecholamine accompanying tracheal intubation and skin incision may be prevented by administration of intravenous clonidine.
Adult
;
Anesthesia
;
Anesthesia, General*
;
Blood Pressure*
;
Brain
;
Clonidine*
;
Epinephrine
;
Heart Rate*
;
Heart*
;
Hemodynamics
;
Hemorrhage
;
Hope
;
Humans
;
Incidence
;
Intubation*
;
Larynx
;
Male
;
Norepinephrine
;
Plasma*
;
Skin
;
Spondylitis, Ankylosing
;
Succinylcholine
;
Thiopental
2.A clinical analysis of breast cancer.
Kyung Soo YU ; Jung Hyo LEE ; Hyun Muck LIM
Journal of the Korean Surgical Society 1993;45(1):23-31
No abstract available.
Breast Neoplasms*
;
Breast*
3.Observation of 17 Asphyxial Suicides by Helium Gas.
Hyoung Soo LIM ; Kyung Won HAHM ; Hyun Wook KANG
Korean Journal of Legal Medicine 2013;37(2):78-83
Since the book "Final Exit: The Practicalities of Self-Deliverance and Assisted Suicide for the Dying" was published in 1991, there has been a worldwide increase in the number of cases of suicidal asphyxiation using helium gas. However, no domestic reports have been published thus far. Recently, we encountered a case of asphyxial suicide by inhalation of helium from inside a plastic bag. Subsequently, we reviewed the records of the Scientific Crime Analysis System of National Police Agency of Korea. There were 17 cases of helium-associated asphyxial suicides between January 1, 2000 and June 30, 2012. The average age of the deceased was 30.6 years with a male to female ratio of approximately 5:1. Thirteen of 17 such deaths occurred in the victims'houses. In all cases, the method of death involved placing a plastic bag over the head with a hose attached to helium tanks. In 6 of 17 cases, the decedents had psychiatric disorders such as depression. As neither characteristic signs of death nor conventional methods for detecting helium gas exist, a thorough investigation of the death scene and the decedents'environment is extremely vital for confirming death due to helium asphyxiation.
Crime
;
Depression
;
Female
;
Head
;
Helium
;
Humans
;
Inhalation
;
Korea
;
Male
;
Plastics
;
Police
;
Suicide
;
Suicide, Assisted
4.Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine.
Mee Kyung NAMGOONG ; Baek Keun LIM ; Joong Soo KIM
Journal of the Korean Pediatric Society 1988;31(10):1275-1280
No abstract available.
Diagnosis*
;
Infant, Newborn
;
Meconium Aspiration Syndrome*
;
Meconium*
5.Dispatcher-assisted telephone cardiopulmonary resuscitation.
Boo Soo LEE ; Sung Oh HWANG ; Young Sik KIM ; Moo Eob AHN ; Kyung Soo LIM
Journal of the Korean Society of Emergency Medicine 1992;3(2):75-85
No abstract available.
Cardiopulmonary Resuscitation*
;
Telephone*
6.Effect of Hydrosalpingeal Fluid on the Implantation in-vitro in a Murine Model.
Jin Hyun JUN ; Chun Kyu LIM ; Soo Kyung KIM ; Mi Kyoung KOONG ; Inn Soo KANG
Korean Journal of Fertility and Sterility 2000;27(2):159-164
No abstract available.
7.High-dose epinephrine therapy in refractory cardiac arrest.
Sung Oh HWANG ; Mu Eob AHN ; Kyung Soo LIM ; Keum Soo PARK ; Kyung Hoon CHOI ; Seong Joon KANG
Journal of the Korean Society of Emergency Medicine 1991;2(1):56-61
No abstract available.
Epinephrine*
;
Heart Arrest*
8.Balloon dilatation of the prostatic urethra.
Yeon Soo LEE ; Hyung Jin SHIM ; Kyung Soo CHA ; Ju Hee HONG ; Myung Ah LIM ; Cheol Soo KIM
Journal of the Korean Radiological Society 1991;27(2):183-188
No abstract available.
Dilatation*
;
Urethra*
9.The Role of CD24 in Mammary Carcinoma.
Jin Soo LIM ; Kyung Jong KIM ; Sung Chul LIM
Journal of the Korean Surgical Society 2005;68(3):173-177
PURPOSE: CD24 is a small heavily glycosylated glycosylphosphatidylinositol-linked cell surface protein, which is expressed in hematological malignancies as well as a large variety of solid tumors. The authors aimed to evaluate the CD24 protein expression in fibroadenomas and adenocarcinomas of the breast and its correlation to clinicopathological data. METHODS: Immunohistochemical staining for CD24 was performed on 28 mammary neoplasia, diagnosed as either adenocarcinomas (22 cases) or fibroadenomas (6 cases), to examine the relationship with clinicopathological parameters. The results of the immunohistochemical staining were evaluated by the stainability (negative, weak-, moderate-, strong-positive) and staining patterns (membranous vs. intracytoplasmic) for statistical analyses. RESULTS: The present study clearly demonstrates that CD24 was abundantly expressed in adenocarcinoma, compared to in fibroadenomas of the breast (P<0.001). Intracytoplasmic staining was noted in the adenocarcinomas only but this was not statistically significant between the adenocarcinoma and fibroadenoma groups. No significant correlations of the CD24 stainability or staining pattern were detected with the nodal status, tumor histological grade or histological subtypes. CONCLUSION: Our data suggest that abundant membranous expression or intracytoplasmic expression of CD24, as detected by immunohistochemistry, is an important tissue marker for a mammary epithelial neoplasm, which could help to define adenocarcinomas from fibroadenomas.
Adenocarcinoma
;
Breast
;
Fibroadenoma
;
Hematologic Neoplasms
;
Immunohistochemistry
;
Neoplasms, Glandular and Epithelial
10.Validation of enzyme immunoassay for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae Type b capsular polysaccharide.
Korean Journal of Pediatrics 2007;50(2):143-150
PURPOSE: This study was conducted to validate enzyme immunoassay (EIA) for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae type b (Hib) capsular polysaccharide. METHOD: We evaluated specificity, repeatability, intermediate precision, accuracy, lower limit of quantification (LLOQ), and stability to validate standardized EIA for the quantitative measurement of human anti-polyribosylribitol phosphate (PRP) IgG antibodies. RESULTS: The results indicated that this EIA showed specificity to HbO-HA antigen and repeatability and intermediate precision were within acceptance criteria (repeatability: CV < or =15%, intermediate precision: CV < or =20%). The EIA-derived results from this laboratory were equivalent to those obtained by the standard radioactive antigen binding assay (RABA) for quantitation of anti-PRP antibodies in the 28 sera. Spiking recovery result was within acceptance criteria (100+/-20%). The precision and accuracy of samples in LLOQ were from -14.7 to -4.7% in nominal values, which were within acceptance criteria (precision: CV < or =25%, accuracy: +/-25%). Freeze-thaw stability and short term temperature stability were within +/-20% of acceptance criteria. CONCLUSIONS: The EIA which is performed at the Center for Vaccine Evaluation and Study Ewha Medical Research Institute, is an appropriate serologic assay which can be used for quantitation of anti-PRP IgG antibodies in human sera.
Academies and Institutes
;
Antibodies*
;
Haemophilus influenzae type b*
;
Haemophilus influenzae*
;
Haemophilus*
;
Humans*
;
Immunoenzyme Techniques*
;
Immunoglobulin G*
;
Sensitivity and Specificity