1.An analysis of the family medicine education of second-grade medical students.
Kyung Ran WON ; Hyun Sung KIM ; Young Sik KIM
Journal of the Korean Academy of Family Medicine 1993;14(3):173-180
No abstract available.
Education*
;
Humans
;
Students, Medical*
2.Clinical study on thyroid diseases in outpatients of family practice.
Hyun Sung KIM ; Kyung Lan WON ; Yeong Sik KIM
Journal of the Korean Academy of Family Medicine 1993;14(2):66-71
No abstract available.
Family Practice*
;
Humans
;
Outpatients*
;
Thyroid Diseases*
;
Thyroid Gland*
3.Effect of Retinoic Acid on Cleft Palate and Palatal Rugae Formation.
Won Mo YANG ; Soo Il KIM ; Kyung Ran PARK ; Young Ho LEE ; Won Sik KIM
Korean Journal of Physical Anthropology 1994;7(2):199-217
For the study on the effect of retinoic acid on the formation of palatal rugae and the cleft palate, retinoic acid was administered orally 150mg/kg of body weight by gastric tube at GD 10.5 to Sprague-Dawley rats. The pregnant rats were sacrificed on GD 17.5 under ether anesthesia, and laparatomized. After removal of uterus, the number of pregnant sacs and fetuses were counted. The fetuses weighed, the MEE (medial edge epithelium) thickness measured and the mitotic figures counted after routine processing and H·E stain. All the palates were photographed, and the number of rugae & the rugal pattern analysed. TEM photographs of MEE cells were observed after routine processing. The results were as follows ; 1. Rat fetus body weight after retinoic acid treatment increased significantly compared with the control group. 2. Mitotic figures in the retinoic acid treated group increased significantly compared with control group. 3. In the retinoic acid treated group, 79.3% of fetuses had cleft palates. Among fetuses with cleft palates, complete cleft palates were 10.6%, incomplete cleft palate 89.4%. Incomplete clefts were of two types ; median type (cleft palate at the intermolar region) and soft palate type (cleft posterior to the 8th rugae). Median type was 64.6% and the soft palate type 35.4%. 4. 2.3% of the fetuses had the numerical anomaly of the palatal rugae in the control group, but that of retinoic acid treated group 87.7%. 5. 17.4% of palatal rugae of the control group was disrupted, but 100% of the retinoic acid treated group disrupted. 6. Rugal papillae were observed in the 15.1% of fetuses of the control group and 63.1% of fetuses of the retinoic acid treated group. 7. Longitudinal rugae were observed in 19% of fetuses of the retinoic acid treated group, but not in the control group. 8. In TEM photographs, cytoplasmic processes, intercellular space, and desmosomes decreased. Swelling of mitochondria & ER were also found in the retinoic acid treated groups. According to the above results, it appears that there is close relationship between palatal rugae and cleft palates, and that excess retinoic acid induces disruption of pattern and numerical variations of rat fetus palate rugae. Also retinoic acid has an inhibitory effect on the proliferation of medial edge epithelial cells of palatal shelves. The cleft palates may be induced by the above mentioned retinoic acid effects. But, the exact mechanisms of retinoic acid on cleft palate formation is not thoroughly known and should be further studied.
Anesthesia
;
Animals
;
Body Weight
;
Cleft Palate*
;
Cytoplasm
;
Desmosomes
;
Epithelial Cells
;
Ether
;
Extracellular Space
;
Fetus
;
Mitochondria
;
Palate
;
Palate, Soft
;
Rats
;
Rats, Sprague-Dawley
;
Tretinoin*
;
Uterus
4.Changes of Psychopathology and Extrapyramidal Symptoms When Co-administering Fluoxetine and Haloperidol.
Min Soo LEE ; Chang Su HAN ; Jae Won KIM ; Kyung Sik WON ; Dong ll KWAK
Journal of the Korean Society of Biological Psychiatry 1997;4(1):121-126
OBJECTIVES: The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. METHOD: We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopathology and extrapyramidal symptoms using positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at o, 2, 4, 6, 8 week during the period. RESULTS: 38 patients have completed the study during 8 week. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. CONCLUSION: When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. There results suggest that it is safe to coadminister fluoxetine to schizophrenic with haloperidol treatment.
Drug Interactions
;
Fluoxetine*
;
Haloperidol*
;
Humans
;
Psychopathology*
5.Pulmonary Alveolar Proteinosis: A case report.
Chang Ho CHO ; Yoon Kyung SOHN ; Jyung Sik KWAK ; Jung Yoon CHOI ; Won Sik LEE ; Tae Hoon JUNG
Korean Journal of Pathology 1991;25(3):263-268
A case of pulmonary alveolar proteinosis is reported. Most of the alveolar spaces were filled with amorphous deep eosinohilic material which revealed strong positive reaction to periodic acid-Schiff staining. Electron microscopic observation of this material showed numerous lamellar bodies in the alveolar spaces and cytoplasms of alveolar macrophages. A part of them were concentric multilamellated type A lamellar bodies and the other were finger printlike type B bodies. Combined type A and type B lamellar bodies were rarely present. From the above features it is suggested that both type A and B lamellar bodies could be transformed one another and those lamellar bodies may be originated from pulmonary surfactant.
6.A Case of Carcinoma Erysipelatoides Associated with Carcinoma Telangiectaticum.
Won Ho LEE ; Dong Sik BANG ; Kyung Hun CHANG ; Soo Il CHUN ; Chang Jo KOH
Korean Journal of Dermatology 1982;20(1):151-155
Carcinoma of the breast can produce cutaneous metastases which sbow highly diversified clinical pictures. The cutaneous metastases produce four definite clinical types: inflammatory carcinoma, telangiectatic carcinoma, nodular carcinoma, and carcinoma, en cuirasse. We present a case of 78-year-old nulliparous woman who had several painful dark purplish colored zosteriform papulovesicular eruptions, suggestive of herpes zoster, on the right breast, right axilla, scapular area, and upper arm for three month. Two month later, well dermacated linearly arranged erysipeloid eruptions appeared around the previous skin lesions and the right chest wall. Histopathological findings showed metastatic ductal carcinoma with massive vascular permeation but the primary focus was undetermined.
Female
;
Humans
;
Neoplasm Metastasis
7.PRENATAL SONOGRAPHIC DIAGNOSIS OF CLEFT LIP * PLATE.
Jeong Hoon KANG ; Kyung Suck KOH ; Shi Joon YOO ; Hye Sung WON ; In Sik LEE ; Ahm KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):943-948
No abstract available.
Cleft Lip*
;
Diagnosis*
;
Ultrasonography*
8.Local production of specific IgE antibody to house dust mite in nasal polyp tissues.
Ji Won KANG ; Dong Ho NAHM ; Kyung Sik SUH ; Hee Yeon KIM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 1998;18(3):426-433
OBJECTIVE: In order to confirm the local production of total and specific IgE antibodies in the nasal polyp tissues. MATERIAL AND METHOD: We measured total IgE and house dust mite(Dermatophagoides pteronpssinus .' DP)-specific IgE antibody using enzyme-linked immunosorbent assay(ELISA) in the supernatant of nasal polyp homogenates from 72 subjects undergoing nasal polypectomy. The subjects were divided into three groups according to skin reactivity to DP: 20 strongly atopic subjects to group I(mean wheal diameter) 3mm), 19 weakly atopic subjects to group II (mean wheal diameter 1-3mm) and 33 negative skin responders to group III. RESULT: Group I showed significantly higher levels of total and DP-specific IgE levels in the nasa
Antibodies
;
Dust*
;
Immunoglobulin E*
;
Nasal Polyps*
;
Pyroglyphidae*
;
Skin
;
United States National Aeronautics and Space Administration
9.Effect of resuspension patterns as different conditions of centrifusion in use of U bottomed microplate.
Lan Hee HAN ; Jang Soo SUH ; Kyung Eun SONG ; Won Gil LEE ; Jay Sik KIM
Korean Journal of Blood Transfusion 1991;2(1):63-68
No abstract available.
10.Clinical evaluation of the Port-A-Cath implantation.
Jin Kyung LEE ; Sung Gyu LEE ; Byung Sik KIM ; Tae Won KWON ; Pyung Chul MIN
Journal of the Korean Cancer Association 1992;24(3):450-455
No abstract available.
Vascular Access Devices*