2.Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes.
Choon Sik SEON ; Kyung Wan MIN ; Seung Yup LEE ; Kyoung Woo NHO ; Se Hwan PARK ; Bo Kyung KOO ; Kyung Ah HAN
Diabetes & Metabolism Journal 2011;35(6):619-627
BACKGROUND: Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes. METHODS: Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis. RESULTS: The mean 10-year CHD and 10-year stroke risks were 14.92+/-11.53% and 4.03+/-3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01). CONCLUSION: The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.
Aged
;
Atherosclerosis
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Blood Pressure
;
Cardiovascular Diseases
;
Carotid Artery Diseases
;
Carotid Intima-Media Thickness
;
Coronary Disease
;
Diabetes Mellitus, Type 2
;
Great Britain
;
Humans
;
Pulse Wave Analysis
;
Risk Assessment
;
Stroke
3.A Case of Scoliosis Due to a Foreign Body (Pencil) in the Colon.
Jeong Sik SEO ; Sun Mi CHUNG ; Eun Jin CHOI ; Jin Kyung KIM ; Un Seok NHO ; Hai Lee CHUNG ; Dae Hyun JOO ; Woo Taek KIM
Journal of the Korean Pediatric Society 2002;45(11):1417-1421
Scoliosis describes a lateral curvature of the spine and is often associated with cosmetic and functional impairments due to severe deformity of the spine. The incidence of adolescent scoliosis is 2-4% of children between 10 and 16 years of age. Eighty five percent of them are idiopathic, in which the most common type of scoliosis is right side-bending. In addition, it is classified into congenital, and secondary scoliosis such as neuromuscular disease and neurofibromatosis. Congenital scoliosis is associated with abnormalities of urinary system(20%), congenital heart diseases(15 %), and other abnormalities(10%) such as syringomyelia. We experienced a case of scoliosis by a foreign body(a pencil) in the colon which has never been reported up to date. A brief review of the literature was made.
Adolescent
;
Child
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Colon*
;
Congenital Abnormalities
;
Foreign Bodies*
;
Heart
;
Humans
;
Incidence
;
Neurofibromatoses
;
Neuromuscular Diseases
;
Scoliosis*
;
Spine
;
Syringomyelia
4.Examination of Endoscopic Mucosal Resection as a Curative Treatment of Early Gastric Cancer.
Jae Kyu SEONG ; Hee Seok MOON ; Yeom Seok LEE ; Seon Mun KIM ; Hyeon Woong YANG ; Seung Won SEO ; Byoung Kyu NA ; Byung Seok LEE ; Seung Moo NHO ; Kyung Sook SHIN ; June Sik CHO ; Jae Sung KIM ; Kyu Sang SONG ; Hyun Yong JEONG
Korean Journal of Gastrointestinal Endoscopy 2002;24(5):255-260
BACKGROUND/AIMS: Endoscopic mucosal resection (EMR) has been accepted as a treatment option for cases of early gastric cancer (EGC) where the probability of lymph node metastasis is low. The purpose of this study was to define the indication and limitation of EMR of EGC. METHODS: We studied thirty-five cases of EGC treated by EMR in Chungnam National University Hospital from January, 1999 to July, 2001. RESULTS: The rate of complete resection on EGC was 94.3% (33/35). The size affected the curability; 94.4% (17/18) of lesions less than 10 mm, 93.3% (14/15) of lesions 11 to 20 mm and 100% (2/2) of those larger than 20 mm were resected completely. The depth of cancer invasion also affected the curability; 100% of lesion was confined to mucosa while 71.4% of those invaded submucosa. Of the thirty-three lesions which were completely resected, twenty-seven lesions had no recurrences during the follow-up period, four lesions were residual cancers and two developed local recurrences. CONCLUSIONS: In curative treatement for EGC with EMR, although follow-up period was short there is a possibility that indications for EMR could extend to the elevated lesion which is larger than 20 mm and to the superficial submucosal (sm1) cancer.
Chungcheongnam-do
;
Follow-Up Studies
;
Lymph Nodes
;
Mucous Membrane
;
Neoplasm Metastasis
;
Neoplasm, Residual
;
Recurrence
;
Stomach Neoplasms*