No abstract available.
Thanatophoric Dysplasia*

No abstract available.
Amniotic Fluid* ; Animals ; Embryonic Structures* ; Female ; Humans* ; Mice*

No abstract available.
Amniotic Fluid* ; Animals ; Embryonic Structures* ; Female ; Humans* ; Mice*

Polymicrobial nature of diabetic foot infection has been well documented in the literature. Initial antibiotic therapy of diabetic foot infection is usually empiric until reliable culture data is shown. This study was carried out to determine the common bacteriological flora of diabetic foot infection and antimicrobial sensitivity pattern in order to enhance possible empiric treatment. The specimens were obtained from wounds of 207 cases of diabetic foot ulcer, and the bacteriological isolation, and antimicrobial susceptibility tests of the isolates were carried out by standard microbiological methods. Staphylococcus aureus was the most common isolate, with 46.2% of recover rate among total bacterial isolated cases. Among gram-negative organisms, Pseudomonas aeruginosa was most common. Gram-positive organisms showed significant susceptibility to clindamycin, trimethoprim/sulfamethoxazole, and levofloxacin, besides vancomycin. Cefoperazone, piperacillin/tazobactam, and amikacin in addition to imipenem were most effective agents compared to gram-negative organisms. Diabetic foot infection requires use of combined antimicrobial therapy for initial management. Our results indicate that the most effective antibiotic combination for diabetic foot infection of Korean patients is clindamycin plus cefoperazone.
Amikacin ; Bacteriology* ; Cefoperazone ; Clindamycin ; Diabetic Foot* ; Humans ; Imipenem ; Levofloxacin ; Pseudomonas aeruginosa ; Staphylococcus aureus ; Ulcer* ; Vancomycin ; Wounds and Injuries

Abdominal pregnancies are classified as primary and secondary. The incidence varies from one in 372 to one in 9714 live birth. When this occurs, perinatal morbidity and mort-ality are high, usually as a result of growth restriction and congenital anomalies such as fetal pulmonary hypoplasia, pressure deformities, facial and limb asymmetry. Omental pregnancy is an extremely rare form of abdominal pregnancy that may cause life-threatening massive hemorrhage in case of rupture. A case of this rare entity is prese- nted after dilatation and curettage in which gestational tissue was found to arise from the edge of greater omentum, requiring partial omentectomy. The diagnosis of omental pregnancy is hardly ever made prior to laparotomy. This case of omental pregnancy, believed to be secondary, was recently experienced and it is reported here with a brief review of the literature.
Congenital Abnormalities ; Diagnosis ; Dilatation and Curettage* ; Dilatation* ; Extremities ; Female ; Hemorrhage ; Incidence ; Laparotomy ; Live Birth ; Omentum ; Pregnancy* ; Pregnancy, Abdominal ; Rupture

Periventricular leukomalacia is a major cause of neuro-developmental delay in premature infant. Although it develops in only a small percentage of preterm infants, the condition poses a major problem. The pathogenesis of periventricular leukomalacia is not well established. Because of the topography of the lesion, a decreased cerebral perfusion occurred before delivery is thought to be a critical pathogenetic factor. Therefore, hypoxic brain damage is thought to be a major cause of periventricular leukomalacia. The importance of neurochemically mediated injury to the white matter has been stressed. Recently, high incidence of placental chorioamnionitis with periventricular leukomalacia. We experienced a case of periventricular leukomalacia related to chorioamnionitis. The pathology of placenta was chorioamniontis, and it was thought to be a cause of periventricular leukomalacia. So, we report our case with a short literature review to ensuring that chorioamionitis without perinatal asphyxia cause a periventricular leukomalacia.
Asphyxia ; Chorioamnionitis* ; Female ; Humans ; Hypoxia, Brain ; Incidence ; Infant, Newborn ; Infant, Premature ; Leukomalacia, Periventricular* ; Pathology ; Perfusion ; Placenta ; Pregnancy

Periventricular leukomalacia is a major cause of neuro-developmental delay in premature infant. Although it develops in only a small percentage of preterm infants, the condition poses a major problem. The pathogenesis of periventricular leukomalacia is not well established. Because of the topography of the lesion, a decreased cerebral perfusion occurred before delivery is thought to be a critical pathogenetic factor. Therefore, hypoxic brain damage is thought to be a major cause of periventricular leukomalacia. The importance of neurochemically mediated injury to the white matter has been stressed. Recently, high incidence of placental chorioamnionitis with periventricular leukomalacia. We experienced a case of periventricular leukomalacia related to chorioamnionitis. The pathology of placenta was chorioamniontis, and it was thought to be a cause of periventricular leukomalacia. So, we report our case with a short literature review to ensuring that chorioamionitis without perinatal asphyxia cause a periventricular leukomalacia.
Asphyxia ; Chorioamnionitis* ; Female ; Humans ; Hypoxia, Brain ; Incidence ; Infant, Newborn ; Infant, Premature ; Leukomalacia, Periventricular* ; Pathology ; Perfusion ; Placenta ; Pregnancy

A 37-year-old woman was admitted for chief complaints about primary amenorrhea and multiple bone pains. She was raised phenotypically female but her chromosomal study was no-rmal male karyotype(46 XY). On pelvic examination, she showed relatively normal female ex-ternal genitalia except short blind-ending vagina. There were also no uterus and tubes in operation field. Even though rare disorder, she was diagnosed male pseudohermaphroditism due to 17-beta -hydroxysteroid dehydrogenase deficiency. This disorder is the most common enzyme defect in biosynthesis of testosterone and involves the last step. The serum level of sex steroid: test osterone, estradiol were decreased and FSH, LH were increased. Androstenedione was increased and we could obtain that Androstenedione / Testosterone ratio was increased. Because of 17-beta-HSD deficiency, estrogen was not converted to estradiol, and so estradiol was markedly decreased. Same as above, we experienced a case of male pseudohermaphroditism due to 17-beta-hydroxysteroid dehydrogenase deficiency with multiple osteoporosis. So we report this case with a brief review of literatures.
46, XY Disorders of Sex Development ; Adult ; Amenorrhea ; Androstenedione ; Estradiol ; Estrogens ; Female ; Genitalia ; Gynecological Examination ; Humans ; Male ; Osteoporosis* ; Oxidoreductases* ; Testosterone ; Uterus ; Vagina

PURPOSE: Total hip arthroplasty was performed using a direct anterior approach (DAA) on an ordinary operation table and a short femoral stem. The clinical radiographic results were evaluated by a comparison with those performed using the modified hardinge (anterolateral approach, ALA) method. MATERIALS AND METHODS: From January 2013 to November 2015, 102 patients who underwent total hip arthroplasty using DAA (DAA group) and the same number of patients using ALA (ALA group), both performed by a single surgeon, were compared and analyzed retrospectively. The operation time and amounts of bleeding were compared, and the improvement in post-operative pain, ambulatory capacity and functional recovery of the hip joint were checked. The location of insertion of the acetabular cup and femoral stem were evaluated radiologically, and the complications that occurred in the two groups were investigated. RESULTS: The amount of bleeding was significantly smaller in the DAA group (p=0.018). Up to 3 weeks postoperatively, recovery of hip muscle strength was significantly higher in the DAA group (flexion/extension strength p=0.023, abduction strength p=0.031). The Harris hip score was significantly better in the DAA group for up to 3 months (p<0.001) and the Koval score showed significantly better results in the DAA group up to 6 weeks (p≤0.001). The visual analogue scale score improvement was significantly higher in the DAA group by day 7 (p=0.035). The inclination angle (p<0.001) and anteversion angle (p<0.001) of the acetabular cup were located in the safe zone of the DAA group more than in the ALA group, and there was no statistically significant difference in the position of the femur stem and leg length difference. During surgery, two cases of greater trochanter fracture occurred in the DAA group (p=0.155). CONCLUSION: The DAA performed in the ordinary operation table using a short femoral stem showed post-operative early functional recovery. Because a simple to use fluoroscope was used during surgery with an anatomical position familiar to the surgeon, it is considered to be useful for the insertion of implants into the desired position and for an approach that is useful for the prevention of leg length differences.
Acetabulum ; Arthroplasty, Replacement, Hip ; Femur ; Hemorrhage ; Hip ; Hip Joint ; Humans ; Leg ; Methods ; Muscle Strength ; Operating Tables ; Retrospective Studies

This study was performed to assist in the prediction of the clinical tolerance of patients with lung cancer to irradiation. MATERIALS AND METHODS: The changes in lung function of 26 patients with lung carcinomas, who had received radiation with curative intent, or postoperative adjuvant radiotherapy, were prospectively studied. Their pulmonary function tests were conducted at presentation, and then at 2 weeks, 2 months, and 6 months, following radiotherapy. RESULTS: When the parameters of postirradiation pulmonary functions (2 weeks, 2 months and 6 months) were compared with the preirradiation baseline data, there was a statistically significant decrease in FEF25~75% at 2 months, but the rest of the parameters showed no significant change following irradiation. However, when the baseline lung function was compared with the lung function at the lowest FVC, in patients with curative radiotherapy, there was a statistically significant decrease of about 10% in the FEV1 and DLCO. CONCLUSION: Preirradiation assessment of pulmonary functions, particularly the FEV1 and DLCO will be useful for the prediction of the clinical tolerance to irradiation.
Humans ; Lung Neoplasms* ; Lung* ; Prospective Studies ; Radiotherapy ; Radiotherapy, Adjuvant ; Respiratory Function Tests