No abstract available.
Humans ; Male

No abstract available.
Humans ; Male

For the study on the effect of retinoic acid on the formation of palatal rugae and the cleft palate, retinoic acid was administered orally 150mg/kg of body weight by gastric tube at GD 10.5 to Sprague-Dawley rats. The pregnant rats were sacrificed on GD 17.5 under ether anesthesia, and laparatomized. After removal of uterus, the number of pregnant sacs and fetuses were counted. The fetuses weighed, the MEE (medial edge epithelium) thickness measured and the mitotic figures counted after routine processing and H·E stain. All the palates were photographed, and the number of rugae & the rugal pattern analysed. TEM photographs of MEE cells were observed after routine processing. The results were as follows ; 1. Rat fetus body weight after retinoic acid treatment increased significantly compared with the control group. 2. Mitotic figures in the retinoic acid treated group increased significantly compared with control group. 3. In the retinoic acid treated group, 79.3% of fetuses had cleft palates. Among fetuses with cleft palates, complete cleft palates were 10.6%, incomplete cleft palate 89.4%. Incomplete clefts were of two types ; median type (cleft palate at the intermolar region) and soft palate type (cleft posterior to the 8th rugae). Median type was 64.6% and the soft palate type 35.4%. 4. 2.3% of the fetuses had the numerical anomaly of the palatal rugae in the control group, but that of retinoic acid treated group 87.7%. 5. 17.4% of palatal rugae of the control group was disrupted, but 100% of the retinoic acid treated group disrupted. 6. Rugal papillae were observed in the 15.1% of fetuses of the control group and 63.1% of fetuses of the retinoic acid treated group. 7. Longitudinal rugae were observed in 19% of fetuses of the retinoic acid treated group, but not in the control group. 8. In TEM photographs, cytoplasmic processes, intercellular space, and desmosomes decreased. Swelling of mitochondria & ER were also found in the retinoic acid treated groups. According to the above results, it appears that there is close relationship between palatal rugae and cleft palates, and that excess retinoic acid induces disruption of pattern and numerical variations of rat fetus palate rugae. Also retinoic acid has an inhibitory effect on the proliferation of medial edge epithelial cells of palatal shelves. The cleft palates may be induced by the above mentioned retinoic acid effects. But, the exact mechanisms of retinoic acid on cleft palate formation is not thoroughly known and should be further studied.
Anesthesia ; Animals ; Body Weight ; Cleft Palate* ; Cytoplasm ; Desmosomes ; Epithelial Cells ; Ether ; Extracellular Space ; Fetus ; Mitochondria ; Palate ; Palate, Soft ; Rats ; Rats, Sprague-Dawley ; Tretinoin* ; Uterus

PURPOSE: This study was to investigate the relation among social support, drinking and smoking and to identify factors affecting high school students' smoking and drinking behaviors. METHODS: Data were collected from 361 high school students (182 students in 2 preparatory schools and 179 students in 2 vocational high schools) who were selected through convenient sampling. Data were analyzed using SPSS 11.5 for Windows. RESULTS: Factors affecting smoking behavior were drinking(OR=15.86. p<0.01), school type(R=11.82, p<0.01), school record(OR=46.62. p<0.001), pocket money (OR= 10.91. p<0.01) and brother's smoking (OR=9.09. p<0.05). Factors affecting drinking behavior were smoking(OR=8.32. p<0.01), school type(OR=2.53. p<0.01), school record(OR=2.35. p<0.01), pocket money(OR=2.01. p<0.05), father's educational background(OR=2.126. p<0.05), mother's drinking(OR= 1.83. p<0.05) and relationship with teacher (OR=2.44. p<0.01). CONCLUSION: The behaviors of drinking and smoking in high school students were highly correlated with each other. School record, school type, pocket money and family member's behaviors influenced student's behaviors. Further study is required to estimate the effect of drinking and smoking intervention programs according to student's characteristics such as school record, school type, pocket money management, and family members' influence.
Drinking Behavior ; Drinking* ; Humans ; Smoke* ; Smoking*

No abstract available.

PURPOSE: The effect of dose escalation of up to 6500 cGy on local control and survival was investigated in locally advanced non-small cell lung cancer. MATERIALS AND METHODS: Ninety eight patients with biopsy-proven unresectable non-small cell lung cancer without distant metastases or medically inoperable patients with lower-stage were treated with definitive radiotherapy alone. Group A were treated by thoracic irradiation, 6000 cGy or less in total tumor dose with daily fractions of 180 to 200 cGy: and group B was treated with 6500 cGy of same daily fractions. RESULTS: The actuarial overall survival rate for the entire group was 54% at 1 year, 26.6% at 2 years and 16.4% at 3 years with a median survival time of 13 months. Statistically significant prognostic factors that affect survival rate were stage and N-stage. However, no improvement in local control and survival has been seen with higher dose radiotherapy(group B). CONCLUSION: Dose escalation of up to 6500 cGy was no effect on local control and survival rate. To increase the survival rate of non-small cell lung cancer hyperfractionated radiotherapy or concurrent chemoradiotherapy should be considered.
Carcinoma, Non-Small-Cell Lung* ; Chemoradiotherapy ; Humans ; Neoplasm Metastasis ; Radiotherapy* ; Survival Rate

No abstract available.
Drug Resistance, Microbial* ; Plasmids* ; Pneumonia*

PURPOSE: The purpose of study was to describe and evaluate the educational status regarding clinical practicum for child health nursing to facilitate student's clinical compliance for the bachelor's degree in Korea. Methods: The study was a descriptive study and included data from 40 institutions among the 53 university nursing programs in Korea(75.5% response rate). Data were collected using mailed semi structured questionnaires and content analysis was done. RESULTS: Findings show that most institutions have common learning objectives for the clinical practicum; neonatal care, high risk infant care, hospitalized child care, and advanced nursing practice. The mode for theoretical credits in child health nursing was 5 to 6 and 3 to 4 credits for clinical practice. The practice settings were prepared to provide diverse experiences, including childcare centers, and community centers with various learning activities. Evaluation for learning outcomes included faculty and instructors. It was pointed out that updating evaluation based on student and faculty feedback is important for a comprehensive practicum evaluation. Conclusions: Findings suggest that there is a -need for a generalized curriculum for clinical practicum and for the expanding role of advanced nursing practice-, a need for diverse clinical settings for practice, and effective guidance and learning activities. It is significantly noted that the attitude and teaching methodologies of clinical instructor's are highly important to effective clinical learning outcomes.
Child ; Child Health* ; Child* ; Child, Hospitalized ; Compliance ; Curriculum ; Educational Status ; Humans ; Infant ; Infant Care ; Korea* ; Learning ; Nursing* ; Postal Service ; Surveys and Questionnaires

No abstract available.
Animals ; Basement Membrane* ; Rats*

PURPOSE: We analyzed climacteric symptoms, bone mineral density (BMD), serum estradiol (E2) and follicle stimulating hormone (FSH) to identify the health benefits of meridian massage in perimenopausal women. METHODS: There were 16 women in the experimental group and 17 people in the control group. Meridian massage was performed for 4 weeks, 3 times a week for 20 minutes each session. The data were collected pre-treatment, posttreatment and 4 weeks after treatment. SPSS/WIN 11.5 was used for data analysis. RESULTS: After meridian massage, there were significant differences in climacteric symptoms (U = 65.50, p = .011) and BMD (U = 65.50, p = .011) between the two groups. The E2 level showed a significant difference between the two groups pre- and posttreatment (U = 75.00, p = .028). FSH showed a significant increase when measured at 4 weeks after the treatment as compared with the amount when measured post-treatment within the control group (z = -2.249, p = .025), experimental group showed a stable change in FSH. but there was no significant difference between the groups. CONCLUSION: In this study, we confirmed the effects of Meridian massage in decreasing climacteric symptoms, inhibiting the decrease of BMD and stabilizing serum hormone in perimenopausal women. Therefore, it can be considered for use as a nursing intervention for health management in perimenopausal women.
Bone Density ; Climacteric ; Estradiol ; Female ; Follicle Stimulating Hormone ; Humans ; Insurance Benefits ; Massage ; Statistics as Topic