PURPOSE: The aim of this retrospective study is to analyze the relationship between local factors and survival rate of dental implant which had been installed and restored in Seoul Veterans Hospital dental center for past 10 years. And when the relationship is found out, it could be helpful to predict the prognosis of dental implants. MATERIALS AND METHODS: A retrospective study of patients receiving root-shaped screw-type dental implants placed from January 2000 to December 2009 was conducted. 6385 implants were placed in 3755 patients. The following data were collected from the dental records and radiographs: patient's age, gender, implant type and surface, length, diameter, location of implant placement, bone quality, prosthesis type. The correlations between these data and survival rate were analyzed. Statistical analysis was performed with the use of Kaplan-Meier analysis, Chi-square test and odds ratio. RESULTS: In all, 6385 implants were placed in 3755 patients (3120 male, 635 female; mean age 65 +/- 10.58 years). 108 implants failed and the cumulative survival rate was 96.33%. There were significant differences in age, implant type and surface, length, location and prosthesis type (P<.05). No significant differences were found in relation to the following factors: gender, diameter and bone quality (P>.05). CONCLUSION: Related factors such as age, implant type, length, location and prosthesis type had a significant effect on the implant survival.
Dental Implants ; Dental Records ; Hospitals, Veterans ; Humans ; Kaplan-Meier Estimate ; Male ; Prognosis ; Prostheses and Implants ; Retrospective Studies ; Survival Rate

PURPOSE: Kidney transplantation from elderly donors is controversial because of decline of received renal function and increased risk of perioperative complication. METHODS: We retrospectively reviewed the records of the 676 patients from 1985 to 2006 in our center. 42 (6.2%) donors were > or =60 years old, and constitue the group 1, and 634 donors (93.8%) were <60 years old (group 2). We analysis graft survival, preoperative and postoperative creatinine, creatinine clearance, acute rejection rate, infection rate, delayed graft fucntion rate, HLA matching between groups. RESULTS: The average donor age in group 1 is 62.8 yr (60~73) and 39.3 yr (16~59) in group 2. Graft survival rate at 1, 5 and 10 years were 92%, 71%, 56% in group 1 vs 92%, 77%, 62% in group 2 (P=0.0831). There was no difference of graft survival between groups. In preoperative serum creatinine or postoperative days 3, 30 creatinine there was not difference between groups. Infection rate was 9.5% (4 patients) in group 1 vs. 7.3% (46 patients) in group 2. Acute rejection rate was 28.6% (12 patients) vs. 30.9% (196 patients). Delayed graft function (DGF) rate was 7.1% (3 patients) vs. 9.0% (57 patients). HLA-AB matching was 1.86 vs. 1.78 and HLA-DR matching was 1.12 vs. 1.06. All were not significantly different between groups. But the elderly donor group has a lower creatinine clearance at postoperative 3, 30 days (P=0.0422, 0.0231). CONCLUSION: The short and long-term survival of kidney transplantation from elderly donors (> or =60) are similar to younger donors (<60). We suggest that use of elderly donors may help to expand the donor pool in kidney transplantation.
Aged ; Creatinine ; Delayed Graft Function ; Graft Survival ; HLA-DR Antigens ; Humans ; Kidney ; Kidney Transplantation ; Rejection (Psychology) ; Retrospective Studies ; Tissue Donors ; Transplants

No abstract available.
Apoptosis* ; Placenta Previa* ; Placenta*

Gradual occlusal attrition is a normal process of aging. However, severe attrition causes pathogenic pulp, occlusal disharmony, functional disorder and esthetic problems. Alteration of vertical dimension should be considered for space regaining for tooth restoration, esthetic improvement or correction of occlusal relationship. Vertical dimension should be determined within the range of minimal invasive process satisfying patient's esthetic requirements and operator's functional goal. And patient's adaptation to newly determined vertical dimension should be assessed simultaneously. Deep overbite is not a simple problem of overbite, instead it is an usually complicated problem with anterior-posterior occlusal relationship. Considering these facts, appropriate restoration of edentulous part as well as improvement of anterior-posterior relationship should be performed to solve this fundamental problems. In this study, a 67 year-old male patient with many worn teeth and loss of posterior teeth was treated with removable partial denture at edentulous mandibular area to increase vertical dimension and fixed prostheses at dentulous maxillary and mandibular area. With these treatments, we attained a satisfactory result in functional and esthetic aspects as a report case.
Aging ; Dentition* ; Denture, Partial, Removable ; Humans ; Male ; Mouth Rehabilitation* ; Mouth* ; Overbite* ; Prostheses and Implants ; Tooth ; Vertical Dimension*

BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular pressure produces myogenic vascular relaxation. Recent attention has focused on the potential role of this myogenic mechanism in the control of tone in the resistance vasculature, and in particular on how this mechanism may contribute to the increased vascular resistance seen in hypertension. Therefore, in the present study, we investigated the role of myogenic tone in the generation and/or maintenance of hypertension. MATERICAL AND METHODS: Myogenic tone was developed by stretching of the basilar arteries of WKY (istar Kyoto rat) and SHR (spontaneously hypertensive rats). Contractile responses, PKC (protein kinase C) immunoblots and translocation of PKC and RhoA were measured. In the presence of extracellular Ca2+ the stretching of the resting vessel evoked a myogenic contraction in the basilar arteries of SHR and WKY. Myogenic tone was significantly greater in SHR than in WKY. However, in the absence of extracellular Ca2+, stretching evoked a myogenic contraction in SHR, but not in WKY. The stretch-induced myogenic tone was inhibited by nifedipine. The effect of nifedipine was similar in both SHR and WKY rats. H-7, calphostin C and Y-27632, also inhibited stretch-induced myogenic tone in both SHR and WKY. The inhibitory effects of these drugs were greater in SHR than in WKY. Immunoblotting showed rho A and PKC alpha were translocated from the cytosol to the cell membrane with stretching in both SHR and WKY. PKC beta, however, was translocated to the cell membrane with stretching in SHR, but not in WKY. CONCLUSION: These results suggest that stretch-induced myogenic tone is significantly greater in SHR than in WKY. Furthermore, the increase in amount and/or activity of PKC beta and ROK (rhoA-associated kinase) may be a key mechanism accounting for the enhanced myogenic tone in SHR.
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine ; Basilar Artery ; Blood Vessels ; Cell Membrane ; Cytosol ; Hypertension ; Immunoblotting ; Nifedipine ; Phosphotransferases ; Protein Kinase C* ; Protein Kinases* ; Rats, Inbred SHR* ; Rats, Inbred WKY ; Relaxation ; rhoA GTP-Binding Protein ; Vascular Resistance

No abstract available.
Amnion* ; Cyclooxygenase 2*

The pathogenesis of spontaneous cervicocephalic arterial dissection is still incompletely understood. The clinical presentation of the arterial dissection depends on the plane where the dissection occurred in the arterial wall. When the outer media or subadventitia is dissected, the intramural hematoma bulges outward to make dissecting aneurysm. When located in the subintima or inner media, the intramural hematoma produces narrowing or occlusion of the vessel lumen. Authors review etiopathogeness, clinical features, diagnosis and management of cerviococephalic arterial dissection.
Aneurysm, Dissecting* ; Brain Ischemia ; Diagnosis ; Hematoma ; Subarachnoid Hemorrhage ; Vertebral Artery*

Osteoma is the most common benign tumor of the paranasal sinuses and the frontal sinus is the most frequently involved site. Osteomas are slow growing osteoblastic lesions commonly seen in the outer table of the calvarium, the mandible, the frontal and ethmoid sinus, and occasionally in tubular bones. They are usually detected during the second to fifth decades of life, and reported ratio of male to female is 1.5:1 to 2:1. The symptoms of osteomas are usually developed as gradual growth. They are headaches, facial pain, proptosis, decreased visual acuity, chemosis, diplopia, epiphora, nonpulsating exophthalmus, and transient blindness. Posterior intracranial extension of a frontoethmoid osteoma may lead to brain abscess, intracranial mucocele, tension pneumocephalus. We experienced a 60-year-old male patient who came to the emergency room with acute and severe left periorbital swelling, red eye, and epiphora lasted for 10 days. In a plain radiographs and computerized tomographic scans, a 2.5 x 2.5 x 3.0 cm well marginated mass impressed by osteoma in frontoethmoidal sinus was detected. After the symptoms subsided by conservative treatment, total excision was made by bicoronal approach. Authors reported a frontoethmoidal osteoma presenting periorbital cellulitis without orbital mucocele, which is very rare symptom.
Blindness ; Brain Abscess ; Cellulitis* ; Diplopia ; Emergency Service, Hospital ; Ethmoid Sinus ; Exophthalmos ; Facial Pain ; Female ; Frontal Sinus* ; Headache ; Humans ; Lacrimal Apparatus Diseases ; Male ; Mandible ; Middle Aged ; Mucocele ; Orbit ; Osteoblasts ; Osteoma* ; Paranasal Sinuses ; Pneumocephalus ; Skull ; Visual Acuity

Brain retraction, aneurysm dissection, and proper neck clipping without compromise of perforating vessel are essential procedures for successful aneurysm surgery. One method of facilitating aneurysm dissection and preventing premature aneurysmal rupture is temporary occlusion of the parent artery. This review included a variety of intraoperative electrophysiological and hemodynamic monitoring related to mainly temporary vessel occlusion during aneurysm surgery.
Aneurysm ; Arteries ; Brain ; Electroencephalography ; Hemodynamics ; Humans ; Intracranial Aneurysm* ; Middle Cerebral Artery* ; Monitoring, Intraoperative* ; Neck ; Parents ; Rupture

PURPOSE: Prostaglandin (PG) E2 is known to be closely related to cancer progression and is inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). 15-PGDH is shown to have tumor suppressor activity and to be down-regulated in various cancers, including colorectal cancer (CRC). Therefore, we evaluated the expression of 15-PGDH and its prognostic effect in patients with CRC. METHODS: 15-PGDH expression was examined by using immunohistochemistry in 77 patients with CRC. Its prognostic significance was statistically evaluated. RESULTS: Negative 15-PGDH expression was noted in 55.8% of the 77 cases of CRC. 15-PGDH expression showed no correlation with any of the various clinicopathologic parameters. The status of lymph node metastasis, tumor-node-metastasis stages, and pre-operative carcinoembryonic antigen levels showed significant prognostic effect. However, univariate analysis revealed down-regulation of 15-PGDH not to be a predictor of poor survival. The 5-year overall survival rate was 71.7% in the group with positive expression of 15-PGDH and 67.1% in the group with negative expression of 15-PGDH, but this difference was not statistically significant (P = 0.751). CONCLUSION: 15-PGDH was down-regulated in 55.8% of the colorectal cancer patients. However, down-regulation of 15-PGDH showed no prognostic value in patients with CRC. Further larger scale or prospective studies are needed to clarify the prognostic effect of 15-PGDH down-regulation in patients with colorectal cancer.
Carcinoembryonic Antigen ; Colorectal Neoplasms ; Down-Regulation ; Humans ; Hydroxyprostaglandin Dehydrogenases ; Immunohistochemistry ; Lymph Nodes ; Neoplasm Metastasis ; Oxidoreductases ; Prognosis ; Survival Rate