No abstract available.

No abstract available.
Ear* ; Hyaluronic Acid*

No abstract available.
Cisplatin* ; Hearing Loss* ; Hearing*

No abstract available.
Glycerol* ; Hearing*

No abstract available.
Hearing*

BACKGROUND AND OBJECTIVES: Raman spectroscopy is a vibrational spectroscopic technique capable of providing details on the chemical composition, molecular structure and molecular interactions in cells and tissues. Its application of distinguishing normal and cancer tissue has been studied in a variety of sites, such as the cervix, lung, larynx and skin. The purpose was to explore spectral changes between normal and cancer tissue in the larynx using Raman spectroscopy to assess the feasibility of using Raman spectroscopy for the early diagnosis of laryngeal cancer. MATERIALS AND METHOD: Laryngeal tissue specimens (13 adjacent normal and 13 cancer tissues) were obtained from patients who underwent total laryngetomy or supracricoid laryngectomy with squamous cell carcinoma of the larynx. The specimens were stored -70 degrees C until use. These specimens were defrosted at room temperature. The Raman spectra from laryngeal tissue specimens could be obtained at 300 mW and 250 scan during 15 minutes of the signal acquisition time using FT-Raman spectroscopy (Bruker Co., Karsruhe, Germany). RESULTS: Raman spectra were different significantly between cancer and adjacent normal tissues of the larynx at 1446 cm-1, 1240 cm-1, 1335 cm-1, and 1655 cm-1 (p=0.007, 0.2, 0.2, 0.3, respectively). The difference of 1446 cm-1 means the change of CH2 bending mode in protein and lipid of malignant tissue. The change of 1335 cm-1 means a decrease in CH3CH2 to a wagging mode of collagen and polynucleotide chain of malignant tissue. The difference of 1240 and 1655 means a decrease in the alpha-helix conformation of collagen. CONCLUSION: This study demonstrates the differences of Raman units between laryngeal cancer and adjacent normal tissue using Raman spectroscopy. In future, Raman spectroscopy may become a useful tool of guided biopsy for accurate pathologic diagnosis and assessment of the adequacy of resection margins.
Biopsy ; Carcinoma, Squamous Cell ; Cervix Uteri ; Collagen ; Diagnosis ; Early Diagnosis ; Female ; Humans ; Laryngeal Neoplasms ; Laryngectomy ; Larynx* ; Lung ; Molecular Structure ; Skin ; Spectrum Analysis ; Spectrum Analysis, Raman*

BACKGROUND AND OBJECTIVES: The treatment goal of both chronic and cholesteatomatous otitis media is to irradicate inflammation and to improve hearing. Recently, it has become more important to improve hearing acuity, and thus ossicular reconstruction has become essential in middle ear surgery. To find out the effective method of ossiculoplasty, we analysed tympanoplasty cases, especially type III and IV by Wullstein, performed in our hospital. MATERIALS AND METHOD: 120 cases of type III and IV tympanoplasty performed from January 1995 to December 2000 were analysed. Age and sex distribution, success rate of hearing improvement, recurrence rate of infection, and extrusion rate were analysed according to implanted material and type of surgery. RESULTS: 1) Success rate of hearing improvement according to the implanted material were 35.7%, 33.3%, 43.5%, and 29.2% in fascia, TORP, PORP, and autologous ossicle, respectively. The success rate was highest for the PORP group and with the average of 37.5%. 2) Recurrence rate of infection according to implanted material were 4.8%, 4.2%, 4.3% with fascia, TORP, and PORP, respectively. Infection was the highest in the autologous ossicle (12.3%), and the average recurrence rate was 6.7%. 3) Extrusion rates according to implanted material were 12.5% (TORP), 4.3% (PORP), and 0%(autologous ossicle). The average was 5.1%. 4) Success rate of hearing improvement according to type of surgery were 51%, 46.7%, and 33.3% in atticotomy, intact canal wall mastoidectomy and open cavity mastoidectomy, respectively. The surgery which conserves the middle ear structure tended to have high success rate. 5) Recurrence rate of infection according to type of surgery were 8%, 6.7%, 6.1% in atticotomy, intact canal wall mastoidectomy, and open cavity mastoidectomy, respectively. CONCLUSION: To obtain better results by operating, we should consider the kind of implantation material and proper type of operation. For better hearing improvement, it is preferable to use TORP or PORP instead of autologous ossicles. Although TORP and PORP tend to extrude more frequently than ossicles, they are still better than autologous ossicles if recurrence of infection is considered. Therefore, it is more preferable to use biocompatible materials such as TORP and PORP with adequate type of operation for tympanoplasty III and IV cases.
Biocompatible Materials ; Ear, Middle ; Fascia ; Hearing ; Inflammation ; Ossicular Prosthesis ; Otitis Media ; Recurrence ; Sex Distribution ; Tympanoplasty*

Knowledge about the mechanism and factors that influence olfaction in laryngectomees remains unclear. The aims of this study were to determine the effect of nasal airflow on olfactory ability, as measured by sniff alone and laryngeal bypass with sniff ; to evaluate varying olfactory abilities according to the status of the speech mechanisms in esophageal speakers (ES) and tracheoesophageal shunt speakers (TES) ; and to assess the relationship between speech acceptability and olfactory ability in laryngectomees. Two laryngectomee groups, consisting of ES and TES, and age-matched controls were analyzed through questionnaires, tests applying a Japanese T&T olfactometer to measure thresholds of odor detection and recognition, intravenous alinamin injection tests, and measures of speech acceptability. The findings that laryngeal bypass with sniff and the TES group demonstrated lower olfactory thresholds and shorter latent times than sniff alone and the ES group was informative about the importance of nasal airflow to the olfactory ability in laryngectomees. Furthermore, the close relationship found between olfactory threshold and speech acceptability showed that the ability to transport airflow through the nasal cavity during speech had a strong influence on olfactory ability in laryngectomees.
Asian Continental Ancestry Group ; Humans ; Nasal Cavity ; Odors ; Smell* ; Surveys and Questionnaires

BACKGROUND AND OBJECTIVES: This study was designed to evaluate relation between frequencies of noise and tinnitus in noise-induced hearing loss and to elucidate mechanism of tinnitus in noise-induced hearing loss. MATERIALS AND METHODS: Four factories were selected, of which noise frequencies were different except one factory. Preliminary screening hearing test with a pure tone audiometer on 1000 and 4000 Hz was done. And if the hearing threshold was over 40 dB, history taking, otological examination, tympanometry, pure tone audiometry on 500, 1000, 2000, 4000, 6000 Hz were done. Noise was measured in 125, 250, 500, 1000, 2000, 4000, 8000 Hz. Tinnitus was measured using 1000, 2000, 4000 Hz pure tone. RESULTS: 1) Hearing loss was most severe in the 4000, 6000 Hz range. 2) In A factory, noise was most intense on 4000 Hz, in B factory on 2000 Hz, and in C and D factory on 1000 Hz. 3) Forty-three workers (42.2%) of total 102 subjects complained tinnitus. And frequency of tinnitus was 4000 Hz in 71 ears (89.9%) among 79 ears with tinnius. CONCLUSION: Regardless of the frequency of noise, most workers complain of 4 kHz tinnitus. And it was in accord with frequency of most severe hearing loss in the noise-induced hearing loss.
Acoustic Impedance Tests ; Audiometry ; Ear ; Hearing ; Hearing Loss ; Hearing Loss, Noise-Induced* ; Hearing Tests ; Mass Screening ; Noise* ; Tinnitus*

BACKGROUND AND OBJECTIVES: Sudden deafness in the elderly is rare and its prognosis is poorer than in adults. The unaffected ear also may have hearing impairment of variable severity and physiological hearing threshold shift termed presbycusis in the elderly. The old person often had various systemic complications including diabetes and hypertension. This study was designed to evaluate clinical manifestations and prognosis of sudden deafness in the elderly and to compare with sudden deafness in adults and children. SUBJECTS AND METHOD: We reviewed the medical and audiological records of 96 patients (102 ears) who are more than 60 years of age, and admitted to the Department of Otolaryngology, Pusan National University Hospital from January 1990 to December 2001. RESULTS: The total recovery rate of sudden deafness was lower in the elderly than in adults and children. Hearing recovery was significantly poorer in the patients with diabetes and hypertension. Hearing recovery was significantly poor in the patients with profound degree of hearing loss. The patients who had been treated within 7 days after onset of hearing loss showed better recovery rate than those treated 7 days later. CONCLUSION: We consider the effect of treatment of sudden deafness in the elderly to be best judged in various degrees of hearing impairment in the unaffected ear. The poor prognosis observed in patients with the concurrent disease is likely to have been brought about by preexisting microvascular diseases of the hearing organ, which is highly affected by aging. Good hearing recovery in the elderly is considered to be associated with time of initial treatment and expected in patients without concurrent diseases.
Adult ; Aged* ; Aging ; Busan ; Child ; Ear ; Hearing ; Hearing Loss ; Hearing Loss, Sudden* ; Humans ; Hypertension ; Otolaryngology ; Presbycusis ; Prognosis